Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 4158263..4158891 Replicon chromosome
Accession NZ_CP026652
Organism Streptomyces dengpaensis strain XZHG99

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag C4B68_RS19145 Protein ID WP_099505875.1
Coordinates 4158263..4158673 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag C4B68_RS19150 Protein ID WP_180289380.1
Coordinates 4158670..4158891 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4B68_RS19125 4153343..4153780 - 438 WP_143674494.1 hypothetical protein -
C4B68_RS41375 4154271..4154774 + 504 WP_143674492.1 hypothetical protein -
C4B68_RS19130 4154706..4155305 - 600 WP_143674491.1 hypothetical protein -
C4B68_RS19135 4156067..4157782 + 1716 WP_143674490.1 hypothetical protein -
C4B68_RS19140 4157779..4158162 + 384 WP_099505876.1 hypothetical protein -
C4B68_RS19145 4158263..4158673 - 411 WP_099505875.1 PIN domain-containing protein Toxin
C4B68_RS19150 4158670..4158891 - 222 WP_180289380.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
C4B68_RS19160 4159538..4160038 + 501 WP_099505874.1 hypothetical protein -
C4B68_RS19170 4160513..4161514 + 1002 WP_099505873.1 iron ABC transporter permease -
C4B68_RS19175 4161511..4162605 + 1095 WP_099505872.1 iron ABC transporter permease -
C4B68_RS19180 4162602..4163516 + 915 WP_099505871.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-42)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14973.74 Da        Isoelectric Point: 5.9963

>T95395 WP_099505875.1 NZ_CP026652:c4158673-4158263 [Streptomyces dengpaensis]
VIYLLDTSGLVRLLRDPKLQSAWYDAIDAAAIASCYVQRAEFLHSARNGREYDEIAEMFTDLYPDVSVPKNAGRWIGAVQ
HRMAQAGEHRSASAVDLIIAATAAHHGLAVLHDDADYRAIARHASDLTEHNVHDVA

Download         Length: 411 bp

>T95395 NZ_CP026652:c4158673-4158263 [Streptomyces dengpaensis]
GTGATCTACTTGCTCGACACGTCCGGCCTGGTCCGGCTGCTCCGCGATCCAAAACTGCAATCGGCCTGGTACGACGCGAT
CGATGCAGCGGCCATCGCATCCTGCTATGTGCAACGTGCCGAGTTTCTCCACAGTGCCCGGAACGGACGCGAGTACGACG
AGATCGCGGAGATGTTCACTGATCTTTACCCCGACGTGTCGGTGCCGAAGAACGCTGGGCGCTGGATCGGCGCGGTGCAA
CACCGTATGGCCCAGGCCGGGGAGCATCGCAGTGCCTCGGCGGTGGATCTCATCATCGCCGCCACCGCGGCCCACCACGG
TCTGGCTGTCCTCCATGACGATGCCGACTACCGTGCTATTGCCCGGCACGCATCCGACCTGACCGAGCACAACGTCCACG
ACGTCGCCTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8506.55 Da        Isoelectric Point: 7.3207

>AT95395 WP_180289380.1 NZ_CP026652:c4158891-4158670 [Streptomyces dengpaensis]
MSVTQIDIDDDALERAMALAKVRTKKEAVNLALNFYAEQQERAARISRHFERAREWGAVEDAERLHRAEKHSR

Download         Length: 222 bp

>AT95395 NZ_CP026652:c4158891-4158670 [Streptomyces dengpaensis]
ATGTCCGTGACGCAGATCGACATCGACGACGACGCTCTGGAACGTGCCATGGCTCTGGCCAAGGTCAGGACCAAGAAGGA
AGCGGTCAATCTCGCTCTGAACTTCTACGCCGAGCAGCAGGAACGTGCGGCACGCATCAGCCGTCACTTCGAGCGTGCGC
GTGAGTGGGGTGCCGTCGAGGACGCCGAGCGTCTGCATCGGGCGGAGAAGCACAGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References