Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-YefM
Location 3175621..3176153 Replicon chromosome
Accession NZ_CP026652
Organism Streptomyces dengpaensis strain XZHG99

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag C4B68_RS14395 Protein ID WP_099499621.1
Coordinates 3175896..3176153 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag C4B68_RS14390 Protein ID WP_099499622.1
Coordinates 3175621..3175899 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4B68_RS14370 3171002..3172039 + 1038 WP_099499626.1 L-glyceraldehyde 3-phosphate reductase -
C4B68_RS14375 3172858..3173370 + 513 WP_099499625.1 DinB family protein -
C4B68_RS14380 3173423..3174331 - 909 WP_099499624.1 LLM class flavin-dependent oxidoreductase -
C4B68_RS14385 3174372..3174965 - 594 WP_099499623.1 dihydrofolate reductase family protein -
C4B68_RS14390 3175621..3175899 + 279 WP_099499622.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
C4B68_RS14395 3175896..3176153 + 258 WP_099499621.1 Txe/YoeB family addiction module toxin Toxin
C4B68_RS14400 3176158..3176808 - 651 WP_099499620.1 OmpA family protein -
C4B68_RS14405 3176812..3177408 - 597 WP_099499619.1 hypothetical protein -
C4B68_RS14410 3177424..3178017 - 594 WP_099500006.1 hypothetical protein -
C4B68_RS14415 3178029..3178229 - 201 WP_099500005.1 hypothetical protein -
C4B68_RS14420 3178338..3179081 - 744 WP_099499618.1 response regulator transcription factor -
C4B68_RS14425 3179074..3180519 - 1446 WP_099499617.1 two-component sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-67)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10100.53 Da        Isoelectric Point: 8.4535

>T95394 WP_099499621.1 NZ_CP026652:3175896-3176153 [Streptomyces dengpaensis]
VKLAFTPQGWEDYVHWQTADRKILKRINRLIDDTLRDPYEGIGKPEPLKHALAGAWSRRITDEHRLVYLPRDAEVIVLQA
RYQYE

Download         Length: 258 bp

>T95394 NZ_CP026652:3175896-3176153 [Streptomyces dengpaensis]
GTGAAGCTGGCCTTCACCCCGCAAGGGTGGGAGGACTACGTCCACTGGCAGACCGCCGACCGGAAGATCCTCAAGCGTAT
TAACCGCCTCATTGACGACACCCTCCGCGACCCGTACGAAGGCATCGGCAAACCCGAACCGCTCAAGCACGCACTGGCCG
GAGCCTGGTCCCGACGTATCACCGATGAACACCGGCTGGTGTACCTCCCCCGGGACGCCGAGGTGATCGTGCTCCAAGCC
CGCTACCAGTACGAATAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10431.45 Da        Isoelectric Point: 4.4663

>AT95394 WP_099499622.1 NZ_CP026652:3175621-3175899 [Streptomyces dengpaensis]
VSITASEARRRLFPLIEEVNSDQSAIEIVSKNGSAYLVAADEYEALLETSYLLRSPANARRLLRSFQHALDGEYESRGLI
RDESDESNEDRR

Download         Length: 279 bp

>AT95394 NZ_CP026652:3175621-3175899 [Streptomyces dengpaensis]
GTGTCGATCACTGCCAGTGAGGCCCGTCGCCGGCTCTTCCCTCTGATCGAAGAGGTCAACAGCGACCAGAGCGCCATAGA
GATCGTCTCCAAGAACGGCAGCGCGTACCTTGTCGCGGCCGACGAGTACGAGGCTCTCCTTGAGACCTCCTACCTGCTGC
GCTCCCCTGCGAACGCCCGCCGACTGCTCCGCTCGTTCCAGCACGCCCTGGACGGCGAGTACGAGAGCCGCGGACTCATT
CGCGACGAGAGCGACGAGAGCAACGAGGACCGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References