Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-DnaT |
| Location | 50357..50879 | Replicon | plasmid pFORC82_3 |
| Accession | NZ_CP026644 | ||
| Organism | Escherichia coli strain FORC_082 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | U9YLU1 |
| Locus tag | FORC82_RS25820 | Protein ID | WP_000638823.1 |
| Coordinates | 50598..50879 (+) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U9Y7J1 |
| Locus tag | FORC82_RS25815 | Protein ID | WP_000121741.1 |
| Coordinates | 50357..50608 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FORC82_RS25765 (FORC82_p600) | 45448..45891 | + | 444 | WP_000964330.1 | NfeD family protein | - |
| FORC82_RS26190 (FORC82_p601) | 45895..46065 | + | 171 | WP_000550720.1 | hypothetical protein | - |
| FORC82_RS25770 (FORC82_p602) | 46076..46522 | + | 447 | WP_001243165.1 | hypothetical protein | - |
| FORC82_RS25775 (FORC82_p603) | 46555..46812 | + | 258 | WP_001542015.1 | hypothetical protein | - |
| FORC82_RS25785 (FORC82_p604) | 47090..47347 | + | 258 | WP_000739144.1 | hypothetical protein | - |
| FORC82_RS25790 (FORC82_p605) | 47351..48346 | + | 996 | WP_001028543.1 | type IV secretion system protein | - |
| FORC82_RS25795 (FORC82_p606) | 48352..48993 | + | 642 | WP_001425343.1 | type IV secretion system protein | - |
| FORC82_RS25800 (FORC82_p607) | 48995..49249 | + | 255 | WP_001043555.1 | EexN family lipoprotein | - |
| FORC82_RS25805 (FORC82_p608) | 49262..49549 | + | 288 | WP_001032611.1 | EexN family lipoprotein | - |
| FORC82_RS25810 (FORC82_p609) | 49622..50257 | + | 636 | WP_015059536.1 | hypothetical protein | - |
| FORC82_RS25815 (FORC82_p610) | 50357..50608 | + | 252 | WP_000121741.1 | hypothetical protein | Antitoxin |
| FORC82_RS25820 (FORC82_p611) | 50598..50879 | + | 282 | WP_000638823.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FORC82_RS25825 (FORC82_p612) | 50947..51246 | + | 300 | WP_000835764.1 | TrbM/KikA/MpfK family conjugal transfer protein | - |
| FORC82_RS25830 (FORC82_p613) | 51249..52484 | + | 1236 | WP_015059538.1 | TcpQ domain-containing protein | - |
| FORC82_RS25835 (FORC82_p614) | 52490..52927 | + | 438 | WP_000539665.1 | type IV pilus biogenesis protein PilM | - |
| FORC82_RS25840 (FORC82_p615) | 53046..53444 | + | 399 | WP_001153665.1 | hypothetical protein | - |
| FORC82_RS25845 (FORC82_p616) | 53465..54049 | + | 585 | WP_001177113.1 | lytic transglycosylase domain-containing protein | - |
| FORC82_RS26880 (FORC82_p617) | 54049..54339 | + | 291 | WP_000865479.1 | conjugal transfer protein | - |
| FORC82_RS25855 (FORC82_p618) | 54410..54730 | + | 321 | WP_000362080.1 | VirB3 family type IV secretion system protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | mcr-1.1 | - | 1..65206 | 65206 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10945.79 Da Isoelectric Point: 10.4997
>T95372 WP_000638823.1 NZ_CP026644:50598-50879 [Escherichia coli]
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
Download Length: 282 bp
>T95372 NZ_CP026644:50598-50879 [Escherichia coli]
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9223.38 Da Isoelectric Point: 3.9823
>AT95372 WP_000121741.1 NZ_CP026644:50357-50608 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
Download Length: 252 bp
>AT95372 NZ_CP026644:50357-50608 [Escherichia coli]
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|