Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsxAB/Xre(antitoxin) |
| Location | 30106..30607 | Replicon | plasmid pFORC82_3 |
| Accession | NZ_CP026644 | ||
| Organism | Escherichia coli strain FORC_082 | ||
Toxin (Protein)
| Gene name | TsxA | Uniprot ID | H1ZXU8 |
| Locus tag | FORC82_RS25630 | Protein ID | WP_000702247.1 |
| Coordinates | 30347..30607 (-) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | TsxB | Uniprot ID | - |
| Locus tag | FORC82_RS25625 | Protein ID | WP_001132407.1 |
| Coordinates | 30106..30357 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FORC82_RS25575 (FORC82_p550) | 25163..25915 | + | 753 | WP_000797966.1 | conjugal transfer protein TraL | - |
| FORC82_RS25580 (FORC82_p551) | 25917..26624 | + | 708 | WP_021503228.1 | hypothetical protein | - |
| FORC82_RS25585 (FORC82_p552) | 26644..26970 | + | 327 | WP_063078684.1 | hypothetical protein | - |
| FORC82_RS25590 (FORC82_p553) | 27101..27538 | - | 438 | WP_000466318.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| FORC82_RS25595 (FORC82_p554) | 27563..27745 | - | 183 | WP_000833470.1 | type II toxin-antitoxin system HicA family toxin | - |
| FORC82_RS26865 (FORC82_p555) | 28042..28485 | + | 444 | WP_000068545.1 | hypothetical protein | - |
| FORC82_RS25605 (FORC82_p556) | 28592..28858 | - | 267 | WP_000681608.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| FORC82_RS25610 (FORC82_p558) | 29278..29556 | - | 279 | WP_000545938.1 | hypothetical protein | - |
| FORC82_RS25625 (FORC82_p562) | 30106..30357 | - | 252 | WP_001132407.1 | transcriptional regulator | Antitoxin |
| FORC82_RS25630 (FORC82_p563) | 30347..30607 | - | 261 | WP_000702247.1 | hypothetical protein | Toxin |
| FORC82_RS25635 | 30659..30883 | - | 225 | WP_000814381.1 | hypothetical protein | - |
| FORC82_RS25640 (FORC82_p565) | 30980..31189 | - | 210 | WP_000866036.1 | hypothetical protein | - |
| FORC82_RS25645 (FORC82_p566) | 31230..31553 | - | 324 | WP_000427403.1 | hypothetical protein | - |
| FORC82_RS25650 (FORC82_p570) | 32134..32463 | - | 330 | WP_000855120.1 | hypothetical protein | - |
| FORC82_RS25665 (FORC82_p573) | 33152..33403 | - | 252 | WP_001132407.1 | transcriptional regulator | - |
| FORC82_RS25670 (FORC82_p574) | 33393..33653 | - | 261 | WP_000702247.1 | hypothetical protein | - |
| FORC82_RS25675 | 33705..33929 | - | 225 | WP_000814381.1 | hypothetical protein | - |
| FORC82_RS25680 (FORC82_p576) | 34026..34235 | - | 210 | WP_000866036.1 | hypothetical protein | - |
| FORC82_RS25685 (FORC82_p577) | 34276..34599 | - | 324 | WP_000427403.1 | hypothetical protein | - |
| FORC82_RS25690 (FORC82_p581) | 35180..35509 | - | 330 | WP_000855120.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | mcr-1.1 | - | 1..65206 | 65206 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 9817.29 Da Isoelectric Point: 10.0665
>T95370 WP_000702247.1 NZ_CP026644:c30607-30347 [Escherichia coli]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
Download Length: 261 bp
>T95370 NZ_CP026644:c30607-30347 [Escherichia coli]
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCCGATCTTGTTTTTCATGAGAAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTGTTTCTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCCGATCTTGTTTTTCATGAGAAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTGTTTCTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9404.77 Da Isoelectric Point: 9.8120
>AT95370 WP_001132407.1 NZ_CP026644:c30357-30106 [Escherichia coli]
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
Download Length: 252 bp
>AT95370 NZ_CP026644:c30357-30106 [Escherichia coli]
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTTAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTTAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|