Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2456903..2457541 Replicon chromosome
Accession NZ_CP026641
Organism Escherichia coli strain FORC_082

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag FORC82_RS12090 Protein ID WP_000813794.1
Coordinates 2457365..2457541 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FORC82_RS12085 Protein ID WP_001270286.1
Coordinates 2456903..2457319 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC82_RS12065 (2452055) 2452055..2452996 - 942 WP_001251313.1 ABC transporter permease -
FORC82_RS12070 (2452997) 2452997..2454010 - 1014 WP_000220415.1 ABC transporter ATP-binding protein -
FORC82_RS12075 (2454028) 2454028..2455173 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
FORC82_RS12080 (2455418) 2455418..2456824 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
FORC82_RS12085 (2456903) 2456903..2457319 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
FORC82_RS12090 (2457365) 2457365..2457541 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
FORC82_RS12095 (2457763) 2457763..2457993 + 231 WP_000494244.1 YncJ family protein -
FORC82_RS12100 (2458085) 2458085..2460046 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
FORC82_RS12105 (2460119) 2460119..2460655 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
FORC82_RS12110 (2460747) 2460747..2461922 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T95355 WP_000813794.1 NZ_CP026641:c2457541-2457365 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T95355 NZ_CP026641:c2457541-2457365 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT95355 WP_001270286.1 NZ_CP026641:c2457319-2456903 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT95355 NZ_CP026641:c2457319-2456903 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References