Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2314306..2314832 | Replicon | chromosome |
| Accession | NZ_CP026641 | ||
| Organism | Escherichia coli strain FORC_082 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | FORC82_RS11370 | Protein ID | WP_000323025.1 |
| Coordinates | 2314545..2314832 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | FORC82_RS11365 | Protein ID | WP_000534858.1 |
| Coordinates | 2314306..2314545 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FORC82_RS11335 (2309669) | 2309669..2310158 | + | 490 | Protein_2198 | class I SAM-dependent methyltransferase | - |
| FORC82_RS26505 (2310636) | 2310636..2311057 | + | 422 | Protein_2199 | hypothetical protein | - |
| FORC82_RS11350 (2311712) | 2311712..2312734 | + | 1023 | Protein_2200 | ISNCY family transposase | - |
| FORC82_RS26510 (2312855) | 2312855..2313004 | + | 150 | WP_011443592.1 | protein YdfW | - |
| FORC82_RS11355 (2313441) | 2313441..2313773 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| FORC82_RS11360 (2313976) | 2313976..2314281 | - | 306 | WP_001326990.1 | protein YdfV | - |
| FORC82_RS11365 (2314306) | 2314306..2314545 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| FORC82_RS11370 (2314545) | 2314545..2314832 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| FORC82_RS11375 (2314904) | 2314904..2315059 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| FORC82_RS11380 (2315243) | 2315243..2315503 | + | 261 | Protein_2207 | antitermination protein | - |
| FORC82_RS11385 (2315781) | 2315781..2315870 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| FORC82_RS11390 (2315925) | 2315925..2316137 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| FORC82_RS11395 (2316438) | 2316438..2316653 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| FORC82_RS26515 (2317017) | 2317017..2317187 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| FORC82_RS11400 (2317407) | 2317407..2317622 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| FORC82_RS11405 (2317627) | 2317627..2317938 | + | 312 | WP_000189910.1 | YdfR family protein | - |
| FORC82_RS11410 (2317935) | 2317935..2318468 | + | 534 | WP_001092971.1 | lysozyme | - |
| FORC82_RS11415 (2318465) | 2318465..2318962 | + | 498 | WP_001071769.1 | DUF2514 domain-containing protein | - |
| FORC82_RS11420 (2319324) | 2319324..2319536 | + | 213 | WP_000066495.1 | cold shock protein CspI | - |
| FORC82_RS11425 (2319547) | 2319547..2319735 | + | 189 | WP_071524604.1 | cold-shock protein | - |
| FORC82_RS11430 (2319738) | 2319738..2319803 | + | 66 | WP_120795388.1 | small protein YnfR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2291426..2329841 | 38415 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T95353 WP_000323025.1 NZ_CP026641:2314545-2314832 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T95353 NZ_CP026641:2314545-2314832 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT95353 WP_000534858.1 NZ_CP026641:2314306-2314545 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT95353 NZ_CP026641:2314306-2314545 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|