Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1867072..1867600 Replicon chromosome
Accession NZ_CP026616
Organism Acinetobacter sp. SWBY1

Toxin (Protein)


Gene name relE Uniprot ID N9N871
Locus tag C3Y93_RS09060 Protein ID WP_000221358.1
Coordinates 1867072..1867365 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID N9NWT9
Locus tag C3Y93_RS09065 Protein ID WP_000246755.1
Coordinates 1867355..1867600 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3Y93_RS09030 1863235..1863627 + 393 WP_104852708.1 Cd(II)/Pb(II)-responsive transcriptional regulator -
C3Y93_RS09035 1863700..1863861 + 162 Protein_1750 IS6 family transposase -
C3Y93_RS09040 1863903..1864205 - 303 WP_005237493.1 helix-turn-helix transcriptional regulator -
C3Y93_RS09045 1864198..1864554 - 357 WP_004668307.1 type II toxin-antitoxin system RelE/ParE family toxin -
C3Y93_RS09050 1865335..1865664 + 330 WP_004827037.1 four-helix bundle copper-binding protein -
C3Y93_RS09055 1865883..1867034 + 1152 WP_058951619.1 IS4 family transposase -
C3Y93_RS09060 1867072..1867365 - 294 WP_000221358.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C3Y93_RS09065 1867355..1867600 - 246 WP_000246755.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
C3Y93_RS09070 1867780..1868724 - 945 WP_104852709.1 copper resistance protein B -
C3Y93_RS09075 1868711..1869049 - 339 WP_004897649.1 hypothetical protein -
C3Y93_RS09080 1869036..1870847 - 1812 WP_034583971.1 copper resistance system multicopper oxidase -
C3Y93_RS09090 1871654..1872358 + 705 WP_104852710.1 IS6-like element IS1008 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1871654..1872358 704


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11292.52 Da        Isoelectric Point: 10.4753

>T95301 WP_000221358.1 NZ_CP026616:c1867365-1867072 [Acinetobacter sp. SWBY1]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Download         Length: 294 bp

>T95301 NZ_CP026616:c1867365-1867072 [Acinetobacter sp. SWBY1]
ATGACTTATAAGCTTTTACGTCACAAGGACTTTACAGCAGAATGGGAAAAACTCCCTGTTGCTATACGAGATCAATTTAA
AAAGAAACTAGCCAAAGTCATAGAGCAGCCACATATTCCAAAGAATATGCTTAGAGGCGATCTTGCAGGTTGCTATAAAA
TCAAATTATTAAAAGCTGGTGTCCGACTTGTCTATCAAGTTAAAGATGATCAGGTAGTTATCCTGCTCATTACCGTCGGA
AAACGAGCTGATAGCATAGTTTATGACGAAGCGAAAAAGCGAATTAAAGACTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9249.64 Da        Isoelectric Point: 4.3142

>AT95301 WP_000246755.1 NZ_CP026616:c1867600-1867355 [Acinetobacter sp. SWBY1]
MATVNFRIDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Download         Length: 246 bp

>AT95301 NZ_CP026616:c1867600-1867355 [Acinetobacter sp. SWBY1]
ATGGCTACTGTTAACTTCAGGATCGATGAAGCCCTTAAAGAAAAATCTTATTCAATCCTTAAAGAGCAAGGTATTGCACC
TACTGATTTCTTCACTAGTATTCTTGAGTATGTTGCTACGACTGGGAAACTGCCTGTCAAAAAAGCTTTGCTTTCGGAAG
AAGATGAAGAATTATTAGCTCTTGTCCGTAAGCGCATTAATGATCCTAAAGAGATGTTTGAGGAAGTCACATTAGATGAC
TTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A1RKP4

Antitoxin

Source ID Structure
AlphaFold DB A0A6A1RJ80

References