Detailed information of TA system TA095297

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pemIK/PRK09812-MazE
• Location: 650054..650637
• Replicon: chromosome
• Accession: NZ_CP026616
• Organism: Acinetobacter sp. SWBY1

Toxin (Protein)

• Gene name: pemK
• Uniprot ID: -
• Locus tag: C3Y93_RS03320
• Protein ID: WP_096900853.1
• Coordinates: 650054..650389 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: pemI
• Uniprot ID: N9CN57
• Locus tag: C3Y93_RS03325
• Protein ID: WP_004973383.1
• Coordinates: 650389..650637 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C3Y93_RS03300	645311..645616	+	306	WP_104852069.1	hypothetical protein	-
C3Y93_RS03305	645760..647133	+	1374	WP_004973390.1	AarF/ABC1/UbiB kinase family protein	-
C3Y93_RS03310	647403..648713	+	1311	WP_104852070.1	acyl-CoA dehydrogenase family protein	-
C3Y93_RS03315	648765..649964	+	1200	WP_104852071.1	acyl-CoA dehydrogenase family protein	-
C3Y93_RS03320	650054..650389	-	336	WP_096900853.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
C3Y93_RS03325	650389..650637	-	249	WP_004973383.1	hypothetical protein	Antitoxin
C3Y93_RS03330	650814..652019	-	1206	WP_104852072.1	alkane 1-monooxygenase	-
C3Y93_RS03335	652186..653139	+	954	WP_096900855.1	AraC family transcriptional regulator	-
C3Y93_RS03340	653145..654320	-	1176	WP_104852073.1	lipid-A-disaccharide synthase	-
C3Y93_RS03345	654547..655434	+	888	WP_104852074.1	sulfite exporter TauE/SafE family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-101)

Antitoxin

• Antitoxin PemI-like (3-80)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12262.07 Da
• Isoelectric Point: 6.2162

>T95297 WP_096900853.1 NZ_CP026616:c650389-650054 [Acinetobacter sp. SWBY1]
MNQGDIYLISLDPTLGHEQQGKRPVFVISPKSFNLITKMPIVLPITSGGNFARNMGFAVELIGGKTTGIVRCDQSRALDF
EARHARFLESSHADVLDEVLARYIAIFSPED

Nucleotide

• Length: 336 bp

>T95297 NZ_CP026616:c650389-650054 [Acinetobacter sp. SWBY1]
ATGAATCAAGGCGATATTTATTTGATTTCATTAGATCCAACACTTGGACATGAACAACAAGGTAAGCGACCTGTATTTGT
TATTTCACCTAAGTCATTTAATCTTATTACTAAAATGCCGATTGTTTTGCCTATTACTTCTGGTGGAAACTTTGCACGAA
ATATGGGTTTCGCTGTAGAGCTTATTGGTGGGAAAACTACAGGTATTGTGCGTTGTGATCAATCTAGAGCTTTAGATTTT
GAAGCTAGACACGCGCGGTTTTTAGAATCCTCGCACGCAGATGTTTTGGATGAGGTTTTAGCAAGATATATCGCAATTTT
TTCACCTGAAGATTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8866.38 Da
• Isoelectric Point: 7.3181

>AT95297 WP_004973383.1 NZ_CP026616:c650637-650389 [Acinetobacter sp. SWBY1]
MIHTNLRKVGGSVMLAVPPTLLKSLGLDAGKEVSLSIVNGKLVVEPKAKPSYKLADLLQEHQALALEQDAWHDVKAVGRE
EI

Nucleotide

• Length: 249 bp

>AT95297 NZ_CP026616:c650637-650389 [Acinetobacter sp. SWBY1]
ATGATTCATACAAACTTGAGAAAAGTAGGTGGTTCGGTCATGCTTGCCGTACCGCCTACATTATTAAAAAGTTTAGGTTT
AGATGCGGGAAAGGAAGTTTCTCTGAGCATTGTGAATGGTAAGTTAGTGGTCGAACCTAAAGCGAAGCCATCTTATAAAT
TGGCTGACTTGCTGCAAGAGCATCAAGCTTTAGCATTAGAGCAAGATGCGTGGCATGATGTAAAAGCAGTTGGGCGAGAA
GAAATCTAA

Structures

Antitoxin

• AlphaFold DB: N9CN57