Detailed information of TA system TA095296

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 522955..523529
• Replicon: chromosome
• Accession: NZ_CP026616
• Organism: Acinetobacter sp. SWBY1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: N9B925
• Locus tag: C3Y93_RS02575
• Protein ID: WP_004973562.1
• Coordinates: 523341..523529 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: C3Y93_RS02570
• Protein ID: WP_104851972.1
• Coordinates: 522955..523338 (-)
• Length: 128 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C3Y93_RS02550	518478..519599	-	1122	WP_104851969.1	phosphotransferase family protein	-
C3Y93_RS02555	519731..520972	-	1242	WP_104851970.1	acyl-CoA dehydrogenase family protein	-
C3Y93_RS02560	521066..521983	+	918	WP_104851971.1	LysR family transcriptional regulator	-
C3Y93_RS02565	522088..522579	-	492	WP_004973565.1	hypothetical protein	-
C3Y93_RS02570	522955..523338	-	384	WP_104851972.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
C3Y93_RS02575	523341..523529	-	189	WP_004973562.1	type II toxin-antitoxin system HicA family toxin	Toxin
C3Y93_RS02580	523662..525056	-	1395	WP_104851973.1	class II fumarate hydratase	-
C3Y93_RS02585	525230..526234	-	1005	WP_104851974.1	SDR family NAD(P)-dependent oxidoreductase	-
C3Y93_RS02590	526296..526664	+	369	WP_104851975.1	sulfurtransferase complex subunit TusD	-
C3Y93_RS02595	526708..527058	+	351	WP_004973555.1	hypothetical protein	-
C3Y93_RS02600	527124..527408	+	285	WP_004973553.1	hypothetical protein	-
C3Y93_RS02605	527467..527778	+	312	WP_026438386.1	TusE/DsrC/DsvC family sulfur relay protein	-
C3Y93_RS02610	527810..528298	-	489	WP_004973550.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7350.46 Da
• Isoelectric Point: 10.2954

>T95296 WP_004973562.1 NZ_CP026616:c523529-523341 [Acinetobacter sp. SWBY1]
MNSKDIIKRLEQEGWYKVGGKGDHEKYKHPEKPGHVVVPHPRKDMPIGTLRNIYKQAGWEWR

Nucleotide

• Length: 189 bp

>T95296 NZ_CP026616:c523529-523341 [Acinetobacter sp. SWBY1]
ATGAACAGCAAAGACATTATTAAGCGTCTTGAGCAGGAAGGCTGGTACAAAGTGGGTGGTAAAGGCGACCATGAAAAGTA
TAAACATCCTGAAAAGCCTGGGCATGTTGTGGTACCACATCCACGTAAAGATATGCCAATAGGAACTCTACGCAATATAT
ATAAACAGGCTGGTTGGGAGTGGAGGTAA

Antitoxin

Protein

• Length: 128 a.a.
• Molecular weight: 14328.16 Da
• Isoelectric Point: 4.3695

>AT95296 WP_104851972.1 NZ_CP026616:c523338-522955 [Acinetobacter sp. SWBY1]
MLYPVYVHKDEDSAYGLTFPDFDGCFSAADELQDIQRMAQEAVEVHFDGEDIPLPEPSSPEQWLGDERFEGGFWLLVDID
TTKVNTKSIRINISMPEALVKRIDAVAKKQHLSRSAFLAKSAEMALH

Nucleotide

• Length: 384 bp

>AT95296 NZ_CP026616:c523338-522955 [Acinetobacter sp. SWBY1]
ATGTTATATCCAGTATATGTTCACAAAGATGAAGATAGCGCATACGGTTTAACCTTTCCTGACTTTGATGGATGCTTTAG
CGCAGCAGATGAGTTGCAAGATATTCAGCGCATGGCACAGGAAGCGGTTGAAGTTCACTTTGATGGTGAAGATATTCCGT
TACCAGAACCATCAAGCCCAGAGCAATGGTTAGGTGATGAGCGATTTGAGGGTGGTTTTTGGTTGTTAGTTGATATTGAT
ACAACAAAAGTAAATACAAAGTCTATTCGTATTAATATCAGCATGCCAGAAGCTTTAGTGAAACGTATTGATGCTGTTGC
AAAAAAACAACATTTAAGCCGTTCGGCATTCTTAGCTAAAAGCGCGGAAATGGCGTTGCATTAA

Structures

Toxin

• AlphaFold DB: N9B925