Detailed information of TA system TA095254

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 2308386..2309364
• Replicon: chromosome
• Accession: NZ_CP026607
• Organism: Bacillus sp. DU-106

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: W8Y388
• Locus tag: C3Y97_RS11920
• Protein ID: WP_000624977.1
• Coordinates: 2308386..2309123 (+)
• Length: 246 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: M1PKC2
• Locus tag: C3Y97_RS11925
• Protein ID: WP_000237819.1
• Coordinates: 2309236..2309364 (+)
• Length: 43 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C3Y97_RS11895	2303999..2304406	+	408	WP_000063587.1	VOC family protein	-
C3Y97_RS11900	2304430..2304810	+	381	WP_000497668.1	methyltransferase	-
C3Y97_RS11905	2304968..2306653	-	1686	WP_063225602.1	alpha-keto acid decarboxylase family protein	-
C3Y97_RS11910	2306761..2307243	+	483	WP_000191888.1	MarR family winged helix-turn-helix transcriptional regulator	-
C3Y97_RS11915	2307410..2308147	+	738	WP_000594152.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
C3Y97_RS11920	2308386..2309123	+	738	WP_000624977.1	stage II sporulation protein SA	Toxin
C3Y97_RS11925	2309236..2309364	+	129	WP_000237819.1	hypothetical protein	Antitoxin
C3Y97_RS11930	2309437..2309613	+	177	WP_000852629.1	stage II sporulation protein SB	-
C3Y97_RS11935	2309633..2310022	-	390	WP_000713863.1	YxeA family protein	-
C3Y97_RS11940	2310234..2311703	+	1470	WP_000287556.1	beta-Ala-His dipeptidase	-
C3Y97_RS11945	2311949..2312758	+	810	WP_000678370.1	C39 family peptidase	-
C3Y97_RS11950	2312784..2313386	+	603	WP_000517279.1	hypothetical protein	-
C3Y97_RS11955	2313630..2313881	-	252	WP_000827560.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (10-243)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 246 a.a.
• Molecular weight: 28307.03 Da
• Isoelectric Point: 8.2998

>T95254 WP_000624977.1 NZ_CP026607:2308386-2309123 [Bacillus sp. DU-106]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Nucleotide

• Length: 738 bp

>T95254 NZ_CP026607:2308386-2309123 [Bacillus sp. DU-106]
ATGATCTCTAACATTCGAATTGGCTTATTTGTTTTAGCGATTGTCTTTGTAGTCCTTGTTTTCTTTTATTGGAAAAATGA
GGAGTTGTACGAGGAGAAAAAGCAACGTATTAGAAAGACTTGGTATGGTTTGTTTATCATATCTGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCAATGGTTATTTTTGTTGATATTGCGTTC
ATTTTAACGCCTAATATTTCAGAAATATGGGGTGCGAAATTTAGCGATATTGGCAAGACAGTTCAATCAATAAAACGATC
ATTAATTGCATCTAAAGCGAGAGGGGAAATATACACGACAATTATTCAAAATGTTAATCCAGCAGTATTCGGTACGATGG
AATGGCATACGGAAGAGGAATATACAAAGAGCTTAAATGCATTTTTAGATTCATATGGGGAAAAGATTGGCGCGAAAATT
GTTGTTTTTGAAGCCGCGAAAGAGTTAAATACAAACTTTCGTGGTATTCGCTCGCAATTTAGTATTATCGTTCCGTTAGA
ACATATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGGATTATACCAGCAAAAATAGTAAGTGACG
TTTTCATTGTTATTGATGGAAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 43 a.a.
• Molecular weight: 4953.36 Da
• Isoelectric Point: 3.9798

>AT95254 WP_000237819.1 NZ_CP026607:2309236-2309364 [Bacillus sp. DU-106]
VVKDYDNDFFKEGNEDTTDFSLIKGDTLQQVEELEEELKRKS

Nucleotide

• Length: 129 bp

>AT95254 NZ_CP026607:2309236-2309364 [Bacillus sp. DU-106]
GTGGTAAAAGATTATGACAATGATTTTTTTAAAGAAGGTAACGAAGATACAACAGATTTCTCTTTAATAAAAGGGGATAC
GTTGCAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATCATAA

Structures

Toxin

• AlphaFold DB: W8Y388

Antitoxin

• AlphaFold DB: M1PKC2