Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 239939..240581 Replicon chromosome
Accession NZ_CP026607
Organism Bacillus sp. DU-106

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag C3Y97_RS01375 Protein ID WP_000635963.1
Coordinates 240231..240581 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag C3Y97_RS01370 Protein ID WP_000004570.1
Coordinates 239939..240226 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3Y97_RS01345 235256..236218 + 963 WP_000961166.1 UV DNA damage repair endonuclease UvsE -
C3Y97_RS01350 236211..236783 - 573 WP_000908523.1 rhomboid family intramembrane serine protease -
C3Y97_RS01355 236877..237236 + 360 WP_000583416.1 holo-ACP synthase -
C3Y97_RS01360 237393..238343 + 951 WP_002004297.1 outer membrane lipoprotein carrier protein LolA -
C3Y97_RS01365 238461..239630 + 1170 WP_000390615.1 alanine racemase -
C3Y97_RS01370 239939..240226 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
C3Y97_RS01375 240231..240581 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
C3Y97_RS01380 240649..242817 + 2169 WP_000426246.1 RNA-binding transcriptional accessory protein -
C3Y97_RS01385 242875..242991 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
C3Y97_RS01390 243187..243645 + 459 WP_000344234.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T95253 WP_000635963.1 NZ_CP026607:240231-240581 [Bacillus sp. DU-106]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

>T95253 NZ_CP026607:240231-240581 [Bacillus sp. DU-106]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT95253 WP_000004570.1 NZ_CP026607:239939-240226 [Bacillus sp. DU-106]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT95253 NZ_CP026607:239939-240226 [Bacillus sp. DU-106]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAATTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References