Detailed information of TA system TA095251

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA(toxin)
• Location: 15403..15995
• Replicon: plasmid unnamed1
• Accession: NZ_CP026605
• Organism: Catenovulum sp. CCB-QB4

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: C2869_RS21770
• Protein ID: WP_108605173.1
• Coordinates: 15747..15995 (-)
• Length: 83 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: C2869_RS21765
• Protein ID: WP_108605172.1
• Coordinates: 15403..15750 (-)
• Length: 116 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2869_RS21745	11173..12435	+	1263	WP_159084279.1	hypothetical protein	-
C2869_RS21750	12448..12870	+	423	WP_108605169.1	phosphate ABC transporter substrate-binding protein	-
C2869_RS21755	13039..13944	-	906	WP_108605170.1	LysR family transcriptional regulator	-
C2869_RS21760	14048..15028	+	981	WP_108605171.1	aldo/keto reductase	-
C2869_RS21765	15403..15750	-	348	WP_108605172.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
C2869_RS21770	15747..15995	-	249	WP_108605173.1	type II toxin-antitoxin system HicA family toxin	Toxin
C2869_RS21775	16389..17951	-	1563	WP_108605174.1	sodium/sugar symporter	-
C2869_RS21780	18227..20179	-	1953	WP_159084280.1	prolyl oligopeptidase family serine peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..208085	208085

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-80)

Antitoxin

• Uncharacterised protein family HicB (54-102)

Sequences

Toxin

Protein

• Length: 83 a.a.
• Molecular weight: 9425.01 Da
• Isoelectric Point: 10.2183

>T95251 WP_108605173.1 NZ_CP026605:c15995-15747 [Catenovulum sp. CCB-QB4]
IGKQEKLLIKLSDARKVFPWNELVTLLSQLGYEKKEMAGSRVRFYHYGNDALLLLHKPHPENELKGGALKSVKSHLKQEG
WL

Nucleotide

• Length: 249 bp

>T95251 NZ_CP026605:c15995-15747 [Catenovulum sp. CCB-QB4]
ATAGGAAAGCAAGAGAAGCTGCTGATCAAGCTTAGTGACGCAAGAAAGGTTTTTCCTTGGAATGAACTCGTCACACTGCT
CTCTCAACTTGGATATGAGAAAAAGGAAATGGCAGGCTCAAGAGTCCGCTTTTATCACTATGGTAATGATGCGTTATTAT
TGTTGCATAAGCCTCATCCAGAAAATGAGCTTAAAGGTGGAGCTTTAAAATCAGTAAAATCTCACCTTAAACAAGAGGGT
TGGTTATGA

Antitoxin

Protein

• Length: 116 a.a.
• Molecular weight: 13096.77 Da
• Isoelectric Point: 4.6144

>AT95251 WP_108605172.1 NZ_CP026605:c15750-15403 [Catenovulum sp. CCB-QB4]
MTYLRYKNYLGTIEPELESNTLFGKLAFIRDVVTYEATTLQELEQEFQRSVDEYLISCEELGRTPQIPCKGSFNIRTGED
LHREAVLAAEGQSLNAFVCDAIREKIARSRSQSLA

Nucleotide

• Length: 348 bp

>AT95251 NZ_CP026605:c15750-15403 [Catenovulum sp. CCB-QB4]
ATGACTTATCTACGTTATAAAAACTATTTAGGCACTATTGAACCAGAACTGGAAAGTAATACTCTTTTTGGTAAGTTAGC
ATTTATCCGAGACGTGGTTACTTATGAGGCAACAACCTTGCAGGAGCTAGAGCAAGAGTTTCAACGTTCAGTAGATGAGT
ATCTTATATCTTGTGAGGAGCTTGGGCGTACGCCTCAAATACCTTGTAAAGGCTCGTTCAATATTCGTACCGGTGAAGAC
TTGCATCGAGAGGCCGTGCTTGCAGCAGAAGGTCAAAGTTTAAATGCATTTGTGTGTGATGCGATCCGTGAAAAGATTGC
AAGATCTCGCTCACAGTCATTAGCTTAA