95196

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4746278..4746794 Replicon chromosome
Accession NZ_CP026586
Organism Klebsiella pneumoniae strain NUHL30457

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag C3483_RS23710 Protein ID WP_004178374.1
Coordinates 4746278..4746562 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag C3483_RS23715 Protein ID WP_002886901.1
Coordinates 4746552..4746794 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3483_RS23690 4741761..4742069 - 309 WP_004210629.1 PTS sugar transporter subunit IIB -
C3483_RS30645 4742154..4742327 + 174 WP_004210630.1 hypothetical protein -
C3483_RS23695 4742330..4743073 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
C3483_RS23700 4743430..4745568 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
C3483_RS23705 4745810..4746274 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
C3483_RS23710 4746278..4746562 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C3483_RS23715 4746552..4746794 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
C3483_RS23720 4746872..4748782 - 1911 WP_004152270.1 BglG family transcription antiterminator -
C3483_RS23725 4748805..4749959 - 1155 WP_004210635.1 lactonase family protein -
C3483_RS23730 4750026..4750766 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T95196 WP_004178374.1 NZ_CP026586:c4746562-4746278 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T95196 NZ_CP026586:c4746562-4746278 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT95196 WP_002886901.1 NZ_CP026586:c4746794-4746552 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT95196 NZ_CP026586:c4746794-4746552 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References