95195

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 4683108..4684445 Replicon chromosome
Accession NZ_CP026586
Organism Klebsiella pneumoniae strain NUHL30457

Toxin (Protein)


Gene name sanaT Uniprot ID -
Locus tag C3483_RS23420 Protein ID WP_032424556.1
Coordinates 4683510..4684445 (+) Length 312 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID -
Locus tag C3483_RS23415 Protein ID WP_023302769.1
Coordinates 4683108..4683503 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3483_RS23385 4678352..4678642 + 291 WP_022615704.1 hypothetical protein -
C3483_RS23390 4678707..4679612 + 906 WP_022615703.1 DUF1738 domain-containing protein -
C3483_RS23395 4679805..4680176 + 372 WP_022615702.1 hypothetical protein -
C3483_RS23400 4680350..4681945 + 1596 WP_023302771.1 TraI domain-containing protein -
C3483_RS23405 4682117..4682581 + 465 WP_022615700.1 GNAT family N-acetyltransferase -
C3483_RS23410 4682587..4682853 - 267 WP_023302770.1 hypothetical protein -
C3483_RS23415 4683108..4683503 + 396 WP_023302769.1 hypothetical protein Antitoxin
C3483_RS23420 4683510..4684445 + 936 WP_032424556.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
C3483_RS23425 4684453..4685142 - 690 WP_023302767.1 hypothetical protein -
C3483_RS23435 4685347..4686141 - 795 WP_023302766.1 RES domain-containing protein -
C3483_RS23440 4686560..4688239 - 1680 WP_004212561.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(34-298)

Antitoxin

Protein of unknown function DUF6088

(7-109)


Sequences

Toxin        


Download         Length: 312 a.a.        Molecular weight: 35389.66 Da        Isoelectric Point: 5.6165

>T95195 WP_032424556.1 NZ_CP026586:4683510-4684445 [Klebsiella pneumoniae]
MLFSDVTDALGIESGAIVEKDHYIVELLHLLKPLTFDTHQLLFAGGTALAKSGIVLNRMSEDVDIKLVPTDTFLSLSRTQ
RKGIRKEIVQTISHAITATDMFSFDDAHPKVTRDEYRYNDIPVRYPQRVAQAPCLRPFIQLELMEANLLEAPEFRDIHTL
VTTLTGKAPVISAFPCATIISTQAEKLVAMLRRTAAVARNIERQDDASLVRHIYDTYCIVQAGNVDMCLLTDFFKQTIEQ
DIQRYGNQYPQFCVSPNDELKMGLDELEHNPLYKTRYQQFVAPMVYGARKVSWDEAYASFRQMALIILDTY

Download         Length: 936 bp

>T95195 NZ_CP026586:4683510-4684445 [Klebsiella pneumoniae]
CTGCTTTTTTCTGATGTAACAGATGCTCTTGGTATTGAGTCCGGCGCTATTGTAGAAAAAGATCACTATATCGTTGAGCT
TTTACATTTACTGAAACCGCTAACATTTGACACTCATCAATTGCTGTTTGCCGGAGGAACTGCACTGGCAAAATCGGGCA
TTGTGCTTAACCGAATGTCGGAAGATGTAGATATAAAACTGGTACCCACAGATACTTTCTTGTCTCTTTCGCGCACCCAG
CGCAAAGGTATTCGTAAAGAGATCGTCCAGACAATTTCTCATGCAATAACTGCAACAGACATGTTCAGCTTTGACGATGC
CCATCCAAAAGTGACGCGGGATGAATATCGTTACAACGACATACCCGTTCGCTATCCGCAGCGGGTAGCGCAAGCACCTT
GCCTGCGTCCTTTTATCCAGTTGGAATTGATGGAAGCAAATTTGCTTGAGGCACCAGAGTTCAGGGATATTCATACACTG
GTGACGACACTTACTGGAAAAGCACCTGTCATTTCAGCCTTCCCCTGCGCCACAATTATCAGTACTCAGGCAGAAAAACT
GGTGGCTATGCTGCGCCGTACTGCAGCAGTTGCGCGTAATATTGAACGCCAGGATGACGCTTCGCTGGTACGTCATATCT
ACGACACATATTGTATCGTGCAGGCAGGCAATGTTGATATGTGTTTGCTTACTGATTTTTTTAAGCAAACCATTGAGCAA
GATATCCAGCGTTATGGCAATCAGTATCCGCAGTTTTGTGTTTCACCAAATGATGAGCTAAAAATGGGGCTGGACGAACT
TGAGCATAACCCGCTTTATAAGACACGCTACCAGCAATTTGTTGCCCCAATGGTATATGGTGCTCGCAAGGTATCGTGGG
ATGAAGCGTATGCTTCCTTTCGTCAAATGGCGTTAATAATTCTAGATACTTACTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14800.08 Da        Isoelectric Point: 11.1078

>AT95195 WP_023302769.1 NZ_CP026586:4683108-4683503 [Klebsiella pneumoniae]
MTIKTRIQSRLKRSKRYVFTRDDFKDIAGYDQIGRVLRDLLKEGQLLKVGYGVYTKARRNSITGKVMPAAPRGSSAVIVE
TLERLKVRYRYEGATQTYNSGESTQIPVSPEIKTSPRFKRALSVGNSKLNG

Download         Length: 396 bp

>AT95195 NZ_CP026586:4683108-4683503 [Klebsiella pneumoniae]
ATGACGATAAAAACACGCATTCAGTCACGACTGAAACGCTCAAAACGCTATGTATTCACTCGTGACGATTTCAAGGATAT
TGCAGGCTATGATCAGATTGGCAGGGTATTGCGCGACCTTCTCAAAGAGGGGCAACTACTGAAGGTGGGCTACGGTGTGT
ACACCAAAGCGCGTCGGAACAGCATTACTGGAAAAGTCATGCCCGCAGCACCAAGGGGATCTTCGGCAGTGATCGTTGAA
ACGCTGGAGCGCCTGAAAGTACGTTACCGCTATGAAGGAGCTACACAGACATATAATAGTGGCGAATCCACGCAAATCCC
CGTGTCACCGGAGATCAAAACATCTCCGCGCTTTAAACGCGCGTTGTCTGTGGGGAACAGCAAACTAAATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References