95154

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3685526..3686175 Replicon chromosome
Accession NZ_CP026581
Organism Proteus mirabilis isolate GN2

Toxin (Protein)


Gene name vagD Uniprot ID B4EZB9
Locus tag C3940_RS17095 Protein ID WP_012368534.1
Coordinates 3685526..3685945 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B4EZC0
Locus tag C3940_RS17100 Protein ID WP_012368535.1
Coordinates 3685942..3686175 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3940_RS17055 3680805..3681683 - 879 WP_017628653.1 23S rRNA pseudouridine(2604) synthase RluF -
C3940_RS17060 3681859..3682773 - 915 WP_004249085.1 fatty acid biosynthesis protein FabY -
C3940_RS17065 3682797..3683234 - 438 WP_004246810.1 D-tyrosyl-tRNA(Tyr) deacylase -
C3940_RS17070 3683315..3683932 - 618 WP_004246809.1 glucose-1-phosphatase -
C3940_RS17085 3684584..3685000 - 417 WP_046334846.1 hypothetical protein -
C3940_RS17090 3684978..3685301 - 324 WP_104731870.1 hypothetical protein -
C3940_RS17095 3685526..3685945 - 420 WP_012368534.1 type II toxin-antitoxin system VapC family toxin Toxin
C3940_RS17100 3685942..3686175 - 234 WP_012368535.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
C3940_RS18830 3686442..3686594 + 153 WP_172764486.1 hypothetical protein -
C3940_RS17105 3687557..3688765 + 1209 WP_060555750.1 DUF262 domain-containing protein -
C3940_RS17110 3688982..3689203 - 222 WP_060555751.1 hypothetical protein -
C3940_RS17115 3689251..3689538 + 288 WP_104731871.1 transposase -
C3940_RS17120 3689988..3690467 + 480 WP_060555753.1 Hcp family type VI secretion system effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(9-56)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15371.88 Da        Isoelectric Point: 7.7288

>T95154 WP_012368534.1 NZ_CP026581:c3685945-3685526 [Proteus mirabilis]
VKKVYMLDTNICSFIMREQPISLLEKLQKCVMNHDTIVISAITYSEMRFGAIGKKASPKHNRLVDAFCERVDAILAWDKA
AVDATTVIKKCLSDVGLPIGNNDSAIAGHAVAVNAILVTNNTREFSRVEGLKIEDWTHV

Download         Length: 420 bp

>T95154 NZ_CP026581:c3685945-3685526 [Proteus mirabilis]
GTGAAAAAAGTCTATATGCTTGATACAAACATTTGTTCTTTTATCATGCGTGAGCAACCTATTTCTTTGCTCGAAAAACT
TCAGAAATGTGTAATGAACCACGATACTATTGTCATATCAGCGATTACTTATTCAGAGATGCGCTTTGGAGCAATAGGAA
AAAAAGCATCACCTAAACACAATCGTTTGGTTGATGCTTTCTGTGAACGCGTTGACGCGATTTTGGCATGGGATAAAGCG
GCGGTAGACGCAACTACCGTGATAAAAAAATGCTTATCTGATGTGGGATTGCCCATAGGAAATAATGATAGCGCGATTGC
TGGTCATGCTGTCGCGGTTAATGCAATATTGGTAACAAATAATACCCGTGAATTTTCACGAGTTGAAGGACTAAAAATAG
AGGACTGGACTCATGTTTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8890.06 Da        Isoelectric Point: 4.4870

>AT95154 WP_012368535.1 NZ_CP026581:c3686175-3685942 [Proteus mirabilis]
MRTRTVAVFKNGSNRAIRLPKDFDFDGVNELEISRDGDCIILRPVKPNWISLQNEEKADSDFLLERDDVIEEGRVIL

Download         Length: 234 bp

>AT95154 NZ_CP026581:c3686175-3685942 [Proteus mirabilis]
ATGAGAACGAGAACTGTAGCTGTATTTAAAAACGGAAGTAACCGAGCCATTCGCTTACCTAAAGATTTCGATTTTGATGG
TGTCAATGAACTCGAGATAAGCCGAGATGGGGATTGTATTATTTTACGCCCTGTAAAACCTAACTGGATTTCATTACAAA
ACGAAGAAAAAGCCGACAGTGATTTCTTGCTTGAACGCGATGATGTTATTGAAGAAGGACGAGTTATTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EZB9

Antitoxin

Source ID Structure
AlphaFold DB B4EZC0

References