Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 82913..84511 Replicon chromosome
Accession NZ_CP026581
Organism Proteus mirabilis isolate GN2

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag C3940_RS00415 Protein ID WP_063108770.1
Coordinates 82913..84256 (-) Length 448 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag C3940_RS00420 Protein ID WP_041701484.1
Coordinates 84260..84511 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3940_RS00395 78530..79714 + 1185 WP_004246423.1 multidrug efflux MFS transporter EmrD -
C3940_RS00400 79824..81356 - 1533 WP_004246422.1 glycerol kinase GlpK -
C3940_RS00405 81399..82214 - 816 WP_004246421.1 aquaporin -
C3940_RS00410 82511..82753 + 243 WP_012368679.1 cell division protein ZapB -
C3940_RS00415 82913..84256 - 1344 WP_063108770.1 type II toxin-antitoxin system HipA family toxin Toxin
C3940_RS00420 84260..84511 - 252 WP_041701484.1 helix-turn-helix domain-containing protein Antitoxin
C3940_RS00425 85087..85605 - 519 WP_004246419.1 ribonuclease E activity regulator RraA -
C3940_RS00430 85714..86631 - 918 WP_049199260.1 1,4-dihydroxy-2-naphthoate polyprenyltransferase -
C3940_RS00435 86730..88070 - 1341 WP_004246417.1 HslU--HslV peptidase ATPase subunit -
C3940_RS00440 88083..88613 - 531 WP_004246416.1 ATP-dependent protease subunit HslV -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-399)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-63)


Sequences

Toxin        


Download         Length: 448 a.a.        Molecular weight: 49787.20 Da        Isoelectric Point: 5.3203

>T95153 WP_063108770.1 NZ_CP026581:c84256-82913 [Proteus mirabilis]
MKAQILSVAMNGDLVGKLTKNTDGGMSFQYAEEWLAEPGARAISLSLPLQKGRIIGSAVYNFFSNLLPDSEAIIDRMQIR
FKVKTNHPFDLLAAVGRDCVGAIQLYSPDTEIPSVMETHAEPLNENQIEELLDGYQTAPLGMSEDVDFRISLAGAQEKTA
LLWYQDCWQRPQGSTPTSHIFKLPIGLIEHHNIDLRESCENEWLCLCIAREFGFPVTNAELAIFGQKKVLIVERFDRKWS
SSGNWLLRLPQEDCCQALSVAPALKYESDGGPGIESIMTLLLGSQKAIDDREMFFKSQILFWMLAAIDGHGKNFSIFIES
GTSFRLTPLYDVMSAFPIFEARGIEIKKAKMAMALQGKNRQYNFSMIQPRHFISTATKVGFPTKTAMELMVDMAEKTDAV
IATVSSQLPADFPEHISNAIFSGLSIQADKIKRWSSGTSSQNMMVSN

Download         Length: 1344 bp

>T95153 NZ_CP026581:c84256-82913 [Proteus mirabilis]
ATGAAAGCTCAAATACTATCTGTTGCTATGAATGGTGATTTGGTTGGTAAACTAACCAAAAATACTGATGGTGGGATGTC
ATTTCAATACGCAGAAGAATGGTTGGCTGAACCAGGAGCGCGGGCAATCTCATTATCACTTCCTTTGCAAAAGGGGCGCA
TAATCGGTAGCGCAGTTTACAATTTCTTCAGCAACCTTTTACCTGATTCTGAGGCAATTATTGATAGAATGCAGATTCGT
TTTAAGGTAAAAACAAACCATCCTTTTGATCTGCTAGCCGCTGTAGGTCGTGACTGTGTTGGCGCAATCCAATTATATTC
TCCTGATACTGAAATTCCATCGGTGATGGAAACCCATGCTGAACCTTTAAATGAAAATCAAATCGAAGAGCTTTTAGACG
GTTATCAAACCGCCCCCCTTGGAATGTCCGAGGATGTAGACTTTCGGATCTCCCTTGCAGGGGCTCAAGAGAAAACAGCA
TTACTTTGGTATCAAGACTGTTGGCAGCGACCACAAGGCAGTACCCCGACAAGTCATATTTTCAAATTGCCCATAGGTCT
GATTGAACACCATAATATTGATCTGCGCGAAAGCTGTGAAAACGAATGGCTATGCTTGTGTATAGCAAGAGAATTTGGAT
TTCCAGTCACCAACGCTGAATTGGCAATATTCGGTCAGAAAAAGGTACTGATCGTAGAGCGTTTTGACCGAAAATGGTCC
TCATCTGGGAACTGGCTGTTGCGCCTTCCCCAAGAGGATTGCTGTCAGGCTTTGAGCGTTGCCCCTGCATTAAAATATGA
ATCTGATGGTGGTCCAGGTATTGAATCTATCATGACGTTGCTTTTGGGCTCACAAAAAGCCATCGACGATAGAGAAATGT
TTTTTAAATCACAAATTCTGTTCTGGATGCTGGCCGCTATAGATGGGCATGGGAAAAACTTTTCCATCTTCATTGAATCT
GGAACATCTTTTCGTTTAACGCCCTTGTATGATGTTATGTCTGCTTTCCCAATTTTTGAAGCACGAGGAATTGAGATAAA
AAAGGCCAAAATGGCTATGGCATTACAAGGAAAAAACAGACAATACAATTTTTCCATGATACAACCTCGTCATTTTATCT
CTACCGCTACAAAGGTCGGGTTTCCAACAAAAACCGCAATGGAGCTAATGGTTGATATGGCCGAAAAGACTGATGCAGTT
ATAGCTACCGTATCATCTCAACTACCTGCGGACTTTCCTGAGCATATCAGTAACGCCATATTTAGTGGGTTATCAATACA
AGCCGATAAGATTAAAAGATGGTCTTCAGGAACGAGCTCACAAAATATGATGGTTTCGAATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9390.83 Da        Isoelectric Point: 9.8955

>AT95153 WP_041701484.1 NZ_CP026581:c84511-84260 [Proteus mirabilis]
MKITTPSMLAAAIHDLRKQSKLTQAQTAEQVGLRQATVSEFENNPESTKLETLFKILASLELELHVVKRGKNLSEGKVWN
KEW

Download         Length: 252 bp

>AT95153 NZ_CP026581:c84511-84260 [Proteus mirabilis]
ATGAAAATTACAACGCCATCAATGTTAGCCGCTGCAATACATGACTTGCGCAAACAAAGTAAATTAACCCAAGCTCAAAC
GGCTGAACAAGTCGGTCTCAGGCAAGCAACTGTCTCTGAATTTGAGAACAACCCAGAATCAACAAAACTCGAAACGCTTT
TCAAAATCCTTGCCTCTTTGGAACTGGAACTACATGTAGTGAAGCGAGGAAAAAACCTGAGTGAGGGTAAGGTTTGGAAT
AAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References