Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 15320..15921 Replicon chromosome
Accession NZ_CP026581
Organism Proteus mirabilis isolate GN2

Toxin (Protein)


Gene name doc Uniprot ID A0A2X2BIG8
Locus tag C3940_RS00065 Protein ID WP_004246497.1
Coordinates 15320..15703 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Z1SPN9
Locus tag C3940_RS00070 Protein ID WP_004246496.1
Coordinates 15700..15921 (-) Length 74 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3940_RS00040 10693..11151 + 459 WP_004249766.1 GNAT family N-acetyltransferase -
C3940_RS00045 11247..11984 - 738 WP_004249950.1 sel1 repeat family protein -
C3940_RS00050 12093..12992 + 900 WP_063108742.1 N-acetylmuramic acid 6-phosphate etherase -
C3940_RS00055 13349..14587 - 1239 WP_020946511.1 HipA domain-containing protein -
C3940_RS00060 14600..14914 - 315 WP_004246498.1 helix-turn-helix domain-containing protein -
C3940_RS00065 15320..15703 - 384 WP_004246497.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
C3940_RS00070 15700..15921 - 222 WP_004246496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C3940_RS00075 16202..17065 - 864 WP_004249947.1 YicC family protein -
C3940_RS00080 17192..17908 + 717 WP_004249760.1 ribonuclease PH -
C3940_RS00085 17990..18634 + 645 WP_004246493.1 orotate phosphoribosyltransferase -
C3940_RS00090 18953..19558 - 606 WP_004246491.1 nucleoid occlusion factor SlmA -
C3940_RS00095 19678..20136 - 459 WP_004246490.1 dUTP diphosphatase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 128 a.a.        Molecular weight: 14471.53 Da        Isoelectric Point: 8.5125

>T95152 WP_004246497.1 NZ_CP026581:c15703-15320 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTGNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

>T95152 NZ_CP026581:c15703-15320 [Proteus mirabilis]
ATGATATGGGTTAGCGCACAGGAAGTTATCGCTTTCCATGATCGTATATTACAACGTTTCCCAGGTGTGGCCGGTATGTC
CGATCCTGGCAGAGCGGAAGCTCTTATTTACCGGGTGCAAAACCGTAAACATTATGAAGGCATTACAGATGTGTTTGAAC
TGGCAGCAACTTATTGGGTCGCTATCGCTCGAGGGCACATATTTAATGACGGTAATAAACGTACCGCATTTTTTGTGACC
ATGACATTTCTCTATCGTAATGGCATCAGGATCCGCGATACTGGCAATATGCTGGAAAACTTAACAGTAGAAGCAGCTAC
AGGTGAGAAAACCGTCGACCAGTTAGCAAAACATCTACAAAACTTGGTAGAGAAAACTAACTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.23 Da        Isoelectric Point: 5.5667

>AT95152 WP_004246496.1 NZ_CP026581:c15921-15700 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp

>AT95152 NZ_CP026581:c15921-15700 [Proteus mirabilis]
ATGCGTACATATACCTCGACACAAGCCCGAGCCAATATTTCAGAAGTATTAGATATTGCGACCCACGGTGAACCTGTTGA
AATCACCCGCAGAGACGGTTGTTCAGCGGTTGTTATCAGTAAAACTGAATTTGAGTCATACCAGAATGCTAAGCTAGATG
CAGAGTTTGATATGATGATGCAACGTCATGGACATACCGTAGAGGCGCTGACAAATCGATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2X2BIG8


Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1SPN9

References