Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3658173..3658822 Replicon chromosome
Accession NZ_CP026571
Organism Proteus mirabilis strain BC11-24

Toxin (Protein)


Gene name vagD Uniprot ID B4EZB9
Locus tag C3Z14_RS17200 Protein ID WP_012368534.1
Coordinates 3658173..3658592 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B4EZC0
Locus tag C3Z14_RS17205 Protein ID WP_012368535.1
Coordinates 3658589..3658822 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3Z14_RS17160 3653451..3654329 - 879 WP_004246812.1 23S rRNA pseudouridine(2604) synthase RluF -
C3Z14_RS17165 3654505..3655419 - 915 WP_004246811.1 fatty acid biosynthesis protein FabY -
C3Z14_RS17170 3655443..3655880 - 438 WP_004246810.1 D-tyrosyl-tRNA(Tyr) deacylase -
C3Z14_RS17175 3655961..3656578 - 618 WP_020946398.1 glucose-1-phosphatase -
C3Z14_RS17190 3657231..3657647 - 417 WP_046334846.1 hypothetical protein -
C3Z14_RS17195 3657625..3657948 - 324 WP_046334845.1 hypothetical protein -
C3Z14_RS17200 3658173..3658592 - 420 WP_012368534.1 type II toxin-antitoxin system VapC family toxin Toxin
C3Z14_RS17205 3658589..3658822 - 234 WP_012368535.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
C3Z14_RS17210 3660114..3660314 + 201 WP_104836792.1 hypothetical protein -
C3Z14_RS17215 3660572..3661522 - 951 WP_104836793.1 reverse transcriptase family protein -
C3Z14_RS18995 3661515..3661661 - 147 WP_158660334.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(9-56)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15371.88 Da        Isoelectric Point: 7.7288

>T95114 WP_012368534.1 NZ_CP026571:c3658592-3658173 [Proteus mirabilis]
VKKVYMLDTNICSFIMREQPISLLEKLQKCVMNHDTIVISAITYSEMRFGAIGKKASPKHNRLVDAFCERVDAILAWDKA
AVDATTVIKKCLSDVGLPIGNNDSAIAGHAVAVNAILVTNNTREFSRVEGLKIEDWTHV

Download         Length: 420 bp

>T95114 NZ_CP026571:c3658592-3658173 [Proteus mirabilis]
GTGAAAAAAGTCTATATGCTTGATACAAACATTTGTTCTTTTATCATGCGTGAGCAACCTATTTCTTTGCTCGAAAAACT
TCAGAAATGTGTAATGAACCACGATACTATTGTCATATCAGCGATTACTTATTCAGAGATGCGCTTTGGAGCAATAGGAA
AAAAAGCATCACCTAAACACAATCGTTTGGTTGATGCTTTCTGTGAACGCGTTGACGCGATTTTGGCATGGGATAAAGCG
GCGGTAGACGCAACTACCGTGATAAAAAAATGCTTATCTGATGTGGGATTGCCCATAGGAAATAATGATAGCGCGATTGC
TGGTCATGCTGTCGCGGTTAATGCAATATTGGTAACAAATAATACCCGTGAATTTTCACGAGTTGAAGGACTAAAAATAG
AGGACTGGACTCATGTTTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8890.06 Da        Isoelectric Point: 4.4870

>AT95114 WP_012368535.1 NZ_CP026571:c3658822-3658589 [Proteus mirabilis]
MRTRTVAVFKNGSNRAIRLPKDFDFDGVNELEISRDGDCIILRPVKPNWISLQNEEKADSDFLLERDDVIEEGRVIL

Download         Length: 234 bp

>AT95114 NZ_CP026571:c3658822-3658589 [Proteus mirabilis]
ATGAGAACGAGAACTGTAGCTGTATTTAAAAACGGAAGTAACCGAGCCATTCGCTTACCTAAAGATTTCGATTTTGATGG
TGTCAATGAACTCGAGATAAGCCGAGATGGGGATTGTATTATTTTACGCCCTGTAAAACCTAACTGGATTTCATTACAAA
ACGAAGAAAAAGCCGATAGTGATTTCTTGCTTGAACGCGATGATGTTATTGAAGAAGGACGAGTTATTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EZB9

Antitoxin

Source ID Structure
AlphaFold DB B4EZC0

References