Detailed information of TA system TA095111

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 27238..27763
• Replicon: plasmid pSE1004839
• Accession: NZ_CP026570
• Organism: Salmonella enterica strain MFDS1004839

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: MFDS1004839_RS24055
• Protein ID: WP_001159863.1
• Coordinates: 27238..27543 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: MFDS1004839_RS24060
• Protein ID: WP_000813641.1
• Coordinates: 27545..27763 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MFDS1004839_RS24010	22619..23178	-	560	Protein_25	inverse autotransporter beta domain-containing protein	-
MFDS1004839_RS24700	23334..23621	+	288	WP_071530243.1	hypothetical protein	-
MFDS1004839_RS24020	23898..24383	-	486	WP_000905606.1	membrane protein	-
MFDS1004839_RS24025	24377..24886	-	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
MFDS1004839_RS24035	24890..25602	-	713	Protein_29	EAL domain-containing protein	-
MFDS1004839_RS24040	25611..26393	-	783	WP_000082169.1	site-specific integrase	-
MFDS1004839_RS24045	26428..26949	-	522	WP_000198608.1	hypothetical protein	-
MFDS1004839_RS24050	26946..27236	-	291	WP_001266176.1	hypothetical protein	-
MFDS1004839_RS24055	27238..27543	-	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
MFDS1004839_RS24060	27545..27763	-	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
MFDS1004839_RS24065	28438..28959	+	522	WP_077681952.1	hypothetical protein	-
MFDS1004839_RS24810	29003..29431	-	429	Protein_36	hypothetical protein	-
MFDS1004839_RS24075	29443..29738	+	296	Protein_37	cytoplasmic protein	-
MFDS1004839_RS24080	30232..31221	+	990	WP_000461382.1	RepB family plasmid replication initiator protein	-
MFDS1004839_RS24085	31548..31709	-	162	WP_015059604.1	hypothetical protein	-
MFDS1004839_RS24090	31762..32148	-	387	WP_000751876.1	YgiW/YdeI family stress tolerance OB fold protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..96994	96994

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T95111 WP_001159863.1 NZ_CP026570:c27543-27238 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 306 bp

>T95111 NZ_CP026570:c27543-27238 [Salmonella enterica]
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT95111 WP_000813641.1 NZ_CP026570:c27763-27545 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT95111 NZ_CP026570:c27763-27545 [Salmonella enterica]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6