Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5952505..5953024 Replicon chromosome
Accession NZ_CP026562
Organism Pseudomonas avellanae strain R2leaf

Toxin (Protein)


Gene name relE Uniprot ID A0A2S4HX27
Locus tag BKM03_RS28565 Protein ID WP_005737226.1
Coordinates 5952505..5952795 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S6UWW5
Locus tag BKM03_RS28570 Protein ID WP_002551444.1
Coordinates 5952785..5953024 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BKM03_RS28535 5948825..5949367 + 543 WP_005737222.1 hypothetical protein -
BKM03_RS28540 5949462..5950091 + 630 WP_005737223.1 NAD(P)H-dependent oxidoreductase -
BKM03_RS28545 5950150..5950764 - 615 WP_005737224.1 histidine phosphatase family protein -
BKM03_RS28550 5950841..5951182 - 342 WP_003380754.1 hypothetical protein -
BKM03_RS28555 5951539..5952276 + 738 WP_005737225.1 hypothetical protein -
BKM03_RS28560 5952298..5952417 - 120 Protein_5268 GNAT family N-acetyltransferase -
BKM03_RS28565 5952505..5952795 - 291 WP_005737226.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BKM03_RS28570 5952785..5953024 - 240 WP_002551444.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BKM03_RS28575 5953200..5953553 - 354 WP_099160269.1 GNAT family N-acetyltransferase -
BKM03_RS28580 5953693..5955132 - 1440 WP_005737228.1 putative DNA binding domain-containing protein -
BKM03_RS28585 5955125..5955757 - 633 WP_005737229.1 DUF4062 domain-containing protein -
BKM03_RS28590 5955945..5956484 - 540 WP_005737230.1 GNAT family N-acetyltransferase -
BKM03_RS28595 5956645..5957139 + 495 WP_005621707.1 hypothetical protein -
BKM03_RS28600 5957412..5957759 + 348 WP_003380765.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-81)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-64)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11092.93 Da        Isoelectric Point: 9.7063

>T95106 WP_005737226.1 NZ_CP026562:c5952795-5952505 [Pseudomonas avellanae]
MTYSLEFDARALKEWHKLGDTVRQQLKKKLATILVAPCVEANRLHALPDCYKIKLRSSGYRLVYQVIDQEVVVFVVAVDK
RERDEVYRKAADRLGG

Download         Length: 291 bp

>T95106 NZ_CP026562:c5952795-5952505 [Pseudomonas avellanae]
ATGACTTATAGCCTCGAATTTGATGCGCGAGCTCTGAAGGAATGGCACAAATTAGGGGATACCGTGCGTCAGCAGCTCAA
GAAAAAGCTGGCTACGATTCTGGTTGCTCCGTGTGTTGAAGCAAATCGCCTGCATGCGTTGCCCGACTGCTACAAAATCA
AGCTGCGCAGCAGCGGCTATCGGCTGGTTTATCAGGTTATTGACCAAGAGGTTGTGGTCTTCGTGGTTGCTGTGGACAAG
CGTGAGCGAGATGAGGTTTACCGTAAGGCGGCTGATCGGTTGGGCGGGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8955.34 Da        Isoelectric Point: 4.6017

>AT95106 WP_002551444.1 NZ_CP026562:c5953024-5952785 [Pseudomonas avellanae]
MASINVRIDDDLKARAYLELEKLGVTPSELLRQTLQYVAERGQLPFKTVLMTEEDEALLATVRERLAAPQRVKVSLDDL

Download         Length: 240 bp

>AT95106 NZ_CP026562:c5953024-5952785 [Pseudomonas avellanae]
ATGGCGTCTATTAATGTTCGTATCGACGACGATCTCAAGGCTCGTGCTTATCTCGAGCTTGAAAAGCTTGGCGTCACCCC
TTCGGAACTGCTGCGCCAAACCCTGCAGTACGTGGCAGAGCGCGGCCAGTTGCCGTTCAAGACCGTACTGATGACCGAGG
AAGACGAAGCCTTGCTTGCAACAGTGCGCGAGCGCCTTGCGGCTCCGCAACGGGTCAAGGTTTCACTGGATGACTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4HX27

Antitoxin

Source ID Structure
AlphaFold DB A0A0K8M1G9

References