Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/-
Location 69918..70396 Replicon plasmid p2_tig3
Accession NZ_CP026559
Organism Pseudomonas amygdali pv. morsprunorum strain R15244

Toxin (Protein)


Gene name relE Uniprot ID A0A2S4ICR4
Locus tag BKM19_RS30315 Protein ID WP_005730619.1
Coordinates 69918..70211 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2S4HLF9
Locus tag BKM19_RS30320 Protein ID WP_003348562.1
Coordinates 70211..70396 (-) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BKM19_RS30275 65333..65614 - 282 WP_015062535.1 hypothetical protein -
BKM19_RS30285 65889..67118 - 1230 WP_015062536.1 IS91 family transposase -
BKM19_RS30290 67099..67380 - 282 WP_015062535.1 hypothetical protein -
BKM19_RS32330 67663..68003 + 341 Protein_86 hypothetical protein -
BKM19_RS30300 68119..68391 + 273 WP_060403602.1 hypothetical protein -
BKM19_RS30305 68604..69278 + 675 WP_081080454.1 MobA/MobL family protein -
BKM19_RS30310 69275..69802 - 528 WP_003348567.1 hypothetical protein -
BKM19_RS30315 69918..70211 - 294 WP_005730619.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BKM19_RS30320 70211..70396 - 186 WP_003348562.1 hypothetical protein Antitoxin
BKM19_RS30325 70483..70776 - 294 WP_060403601.1 HU family DNA-binding protein -
BKM19_RS30330 71099..71380 + 282 WP_015062535.1 hypothetical protein -
BKM19_RS30335 71361..72590 + 1230 WP_015062536.1 IS91 family transposase -
BKM19_RS30345 72878..73387 + 510 WP_005735414.1 peptide deformylase -
BKM19_RS30350 73531..73804 + 274 Protein_96 IS21 family transposase -
BKM19_RS30355 74016..74981 + 966 WP_024420007.1 isopenicillin N synthase family oxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..168854 168854
- inside IScluster/Tn - - 64123..72590 8467


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11192.94 Da        Isoelectric Point: 6.2150

>T95100 WP_005730619.1 NZ_CP026559:c70211-69918 [Pseudomonas amygdali pv. morsprunorum]
MLPIFWLESADNDLAAIIEYIGLRDIAAAERLWQRLRSIVLPLSEHPYLYAISDRVPGMREIVAHPNYLVFYRVTSTRIE
VVNVVHARQEYPQTGLA

Download         Length: 294 bp

>T95100 NZ_CP026559:c70211-69918 [Pseudomonas amygdali pv. morsprunorum]
ATGCTACCCATTTTCTGGCTAGAATCAGCGGACAACGATTTGGCGGCAATAATCGAATACATAGGTTTACGTGATATAGC
TGCTGCCGAAAGGTTGTGGCAGCGCTTGCGTAGCATCGTTCTGCCCCTTTCAGAACATCCTTATCTGTATGCGATAAGTG
ACCGCGTTCCAGGAATGCGCGAGATCGTTGCCCATCCTAACTACCTGGTGTTTTATCGTGTCACCTCAACGCGCATAGAA
GTGGTGAACGTCGTCCACGCACGGCAAGAATATCCCCAAACTGGACTAGCGTAG

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 7134.04 Da        Isoelectric Point: 6.4675

>AT95100 WP_003348562.1 NZ_CP026559:c70396-70211 [Pseudomonas amygdali pv. morsprunorum]
MIDRSPIVSEFETEELEANYTAWLRAKVEASLADSRPAIPHDEVERRMAERLARLRHRRAS

Download         Length: 186 bp

>AT95100 NZ_CP026559:c70396-70211 [Pseudomonas amygdali pv. morsprunorum]
ATGATTGATCGTTCGCCTATCGTTTCGGAGTTTGAAACTGAAGAGCTAGAGGCCAATTACACCGCCTGGCTACGCGCGAA
GGTGGAGGCAAGTCTGGCCGACTCGCGCCCTGCTATCCCGCATGATGAAGTCGAGCGAAGGATGGCAGAGCGGTTGGCAC
GATTGCGCCATCGCCGAGCGTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4ICR4

Antitoxin

Source ID Structure
AlphaFold DB A0A2S4HLF9

References