Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 210952..211532 Replicon chromosome
Accession NZ_CP026558
Organism Pseudomonas amygdali pv. morsprunorum strain R15244

Toxin (Protein)


Gene name PumA Uniprot ID A0A2G4CV40
Locus tag BKM19_RS01670 Protein ID WP_044322659.1
Coordinates 211233..211532 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A2G4CUT8
Locus tag BKM19_RS01665 Protein ID WP_003407168.1
Coordinates 210952..211236 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BKM19_RS01645 207157..208242 - 1086 WP_002556026.1 DUF3616 domain-containing protein -
BKM19_RS01650 208393..208614 + 222 WP_004666801.1 hypothetical protein -
BKM19_RS01655 209178..210196 - 1019 Protein_207 tyrosine protein phosphatase -
BKM19_RS01660 210569..210877 + 309 WP_180275929.1 DUF4113 domain-containing protein -
BKM19_RS01665 210952..211236 - 285 WP_003407168.1 putative addiction module antidote protein Antitoxin
BKM19_RS01670 211233..211532 - 300 WP_044322659.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BKM19_RS01680 212085..212501 + 417 WP_060403106.1 hypothetical protein -
BKM19_RS01690 212897..213550 + 654 WP_060403115.1 AAA family ATPase -
BKM19_RS01695 213639..213890 + 252 WP_003348789.1 ribbon-helix-helix protein, CopG family -
BKM19_RS01700 214155..214796 + 642 WP_060403107.1 SOS response-associated peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 113913..273504 159591


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Uncharacterized protein HI1420

(10-92)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11170.80 Da        Isoelectric Point: 9.9231

>T95097 WP_044322659.1 NZ_CP026558:c211532-211233 [Pseudomonas amygdali pv. morsprunorum]
MTTIKQTSTYMAWERRLKDQKAKAAIAARIFRVANGLMGDVSPVGQGVSELRIHVGPGYRVYFQQRGDELILLLCGGDKS
SQSRDIETAKKLADQWWQE

Download         Length: 300 bp

>T95097 NZ_CP026558:c211532-211233 [Pseudomonas amygdali pv. morsprunorum]
ATGACGACGATAAAACAGACCTCTACCTATATGGCTTGGGAACGCAGGCTTAAAGACCAGAAGGCCAAAGCTGCAATTGC
CGCTCGTATTTTTAGAGTTGCAAATGGCCTGATGGGTGATGTCTCTCCAGTAGGACAGGGCGTTAGTGAGCTACGGATAC
ACGTTGGCCCTGGTTACCGTGTTTATTTCCAGCAGCGAGGCGATGAACTGATCTTGCTGCTGTGCGGTGGTGACAAGAGC
AGCCAATCCCGAGATATCGAAACAGCCAAGAAACTGGCTGATCAATGGTGGCAAGAATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10277.83 Da        Isoelectric Point: 5.0916

>AT95097 WP_003407168.1 NZ_CP026558:c211236-210952 [Pseudomonas amygdali pv. morsprunorum]
MKEQIFDYDPAAALDGPEAIAIFISDAFETGDAEYIAKAMGVVARAKGMTELARETGLSREQLYRSFSSKGNPTLKTMLT
VMRALGVDMTARMH

Download         Length: 285 bp

>AT95097 NZ_CP026558:c211236-210952 [Pseudomonas amygdali pv. morsprunorum]
ATGAAAGAACAAATTTTCGATTACGACCCAGCAGCAGCCCTTGACGGTCCTGAAGCAATCGCGATTTTTATCTCTGATGC
CTTTGAGACGGGGGATGCGGAGTACATCGCGAAGGCTATGGGGGTTGTCGCAAGGGCCAAAGGGATGACCGAGCTTGCGC
GCGAGACAGGTCTGTCTCGAGAGCAGCTTTATCGGTCGTTCAGTAGCAAGGGCAATCCAACCTTAAAAACCATGTTGACG
GTAATGAGAGCCCTGGGCGTGGATATGACAGCTCGAATGCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G4CV40

Antitoxin

Source ID Structure
AlphaFold DB A0A2G4CUT8

References