Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafQ-DinJ |
| Location | 749309..749874 | Replicon | chromosome |
| Accession | NZ_CP026548 | ||
| Organism | Faecalibacterium prausnitzii strain 942/30-2 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | C7H6P5 |
| Locus tag | C3706_RS03700 | Protein ID | WP_002596328.1 |
| Coordinates | 749584..749874 (+) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | C7H6P4 |
| Locus tag | C3706_RS03695 | Protein ID | WP_005924829.1 |
| Coordinates | 749309..749587 (+) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C3706_RS03650 | 744504..745016 | - | 513 | WP_003533443.1 | RNA polymerase sigma factor | - |
| C3706_RS03655 | 745274..745402 | - | 129 | Protein_698 | hypothetical protein | - |
| C3706_RS03660 | 745466..746278 | - | 813 | WP_113998922.1 | type IV secretory system conjugative DNA transfer family protein | - |
| C3706_RS03670 | 746394..746759 | - | 366 | WP_102288181.1 | hypothetical protein | - |
| C3706_RS03675 | 746838..747032 | - | 195 | WP_014081137.1 | transposon-encoded TnpW family protein | - |
| C3706_RS03680 | 747076..747939 | - | 864 | WP_158394901.1 | ATP-binding protein | - |
| C3706_RS03685 | 747936..748670 | - | 735 | WP_118207843.1 | phage replisome organizer N-terminal domain-containing protein | - |
| C3706_RS03690 | 748784..749182 | - | 399 | WP_158394902.1 | cysteine-rich VLP domain-containing protein | - |
| C3706_RS03695 | 749309..749587 | + | 279 | WP_005924829.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| C3706_RS03700 | 749584..749874 | + | 291 | WP_002596328.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| C3706_RS03705 | 749982..751427 | - | 1446 | WP_158394903.1 | MobA/MobL family protein | - |
| C3706_RS03710 | 751615..751905 | - | 291 | WP_158394904.1 | DUF3847 domain-containing protein | - |
| C3706_RS03715 | 751934..752395 | - | 462 | WP_158394905.1 | sigma-70 family RNA polymerase sigma factor | - |
| C3706_RS03720 | 752406..752858 | - | 453 | WP_158394906.1 | RNA polymerase subunit sigma-24 | - |
| C3706_RS03725 | 752962..753375 | - | 414 | WP_158394907.1 | sigma-70 family RNA polymerase sigma factor | - |
| C3706_RS03730 | 753901..754074 | - | 174 | WP_081026450.1 | cysteine-rich KTR domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 688739..754846 | 66107 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11112.87 Da Isoelectric Point: 8.0630
>T95092 WP_002596328.1 NZ_CP026548:749584-749874 [Faecalibacterium prausnitzii]
MKETKYTVKYTTSFKKDYKRAIKRGLKIELLEQVVALLAMGEPLPDKNRDHDLSGDWAGHRECHILPDWLLVYRIEDDVL
VLTLARTGTHSDLFGK
MKETKYTVKYTTSFKKDYKRAIKRGLKIELLEQVVALLAMGEPLPDKNRDHDLSGDWAGHRECHILPDWLLVYRIEDDVL
VLTLARTGTHSDLFGK
Download Length: 291 bp
>T95092 NZ_CP026548:749584-749874 [Faecalibacterium prausnitzii]
ATGAAAGAAACCAAATATACCGTCAAGTACACGACCAGTTTCAAAAAAGACTACAAACGAGCCATCAAGCGTGGCTTGAA
GATTGAGCTGCTGGAGCAGGTCGTAGCGTTGCTGGCGATGGGCGAACCGCTGCCGGATAAGAACCGTGACCATGACCTGT
CCGGCGATTGGGCAGGCCATCGGGAATGTCATATTCTCCCGGACTGGCTGCTTGTCTACCGCATAGAAGATGATGTTCTG
GTGCTGACGCTGGCCCGCACCGGCACACACAGCGACTTGTTCGGCAAATAA
ATGAAAGAAACCAAATATACCGTCAAGTACACGACCAGTTTCAAAAAAGACTACAAACGAGCCATCAAGCGTGGCTTGAA
GATTGAGCTGCTGGAGCAGGTCGTAGCGTTGCTGGCGATGGGCGAACCGCTGCCGGATAAGAACCGTGACCATGACCTGT
CCGGCGATTGGGCAGGCCATCGGGAATGTCATATTCTCCCGGACTGGCTGCTTGTCTACCGCATAGAAGATGATGTTCTG
GTGCTGACGCTGGCCCGCACCGGCACACACAGCGACTTGTTCGGCAAATAA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10247.66 Da Isoelectric Point: 4.4692
>AT95092 WP_005924829.1 NZ_CP026548:749309-749587 [Faecalibacterium prausnitzii]
MAGNTTNISIRMDADLKAQADALFTELGMNLTTAFNIFVRQSLREGGIPFEVRLEQPNKETVAAMLEAERIAKDPSVKGY
NDLDELFADLKR
MAGNTTNISIRMDADLKAQADALFTELGMNLTTAFNIFVRQSLREGGIPFEVRLEQPNKETVAAMLEAERIAKDPSVKGY
NDLDELFADLKR
Download Length: 279 bp
>AT95092 NZ_CP026548:749309-749587 [Faecalibacterium prausnitzii]
ATGGCTGGAAATACCACAAACATCAGTATCCGCATGGACGCAGATTTGAAAGCGCAGGCGGACGCACTGTTTACTGAACT
TGGCATGAACCTGACTACGGCGTTTAACATCTTTGTGCGCCAGTCGCTTCGTGAAGGCGGCATTCCCTTTGAAGTAAGGC
TGGAACAGCCGAACAAAGAAACGGTTGCTGCCATGCTGGAAGCGGAAAGGATTGCAAAAGACCCGTCTGTAAAGGGCTAC
AATGACCTTGACGAGTTATTTGCTGACCTGAAAAGATGA
ATGGCTGGAAATACCACAAACATCAGTATCCGCATGGACGCAGATTTGAAAGCGCAGGCGGACGCACTGTTTACTGAACT
TGGCATGAACCTGACTACGGCGTTTAACATCTTTGTGCGCCAGTCGCTTCGTGAAGGCGGCATTCCCTTTGAAGTAAGGC
TGGAACAGCCGAACAAAGAAACGGTTGCTGCCATGCTGGAAGCGGAAAGGATTGCAAAAGACCCGTCTGTAAAGGGCTAC
AATGACCTTGACGAGTTATTTGCTGACCTGAAAAGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1M4XBM1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1M4XB19 |