Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazE-MazF |
Location | 97308..97870 | Replicon | plasmid unnamed3 |
Accession | NZ_CP026547 | ||
Organism | Cupriavidus metallidurans strain Ni-2 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | A0A132H7S3 |
Locus tag | C3Z06_RS32345 | Protein ID | WP_024569645.1 |
Coordinates | 97308..97556 (+) | Length | 83 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | A0A132H6K9 |
Locus tag | C3Z06_RS32350 | Protein ID | WP_024569644.1 |
Coordinates | 97550..97870 (+) | Length | 107 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
C3Z06_RS33290 | 93707..94252 | - | 546 | WP_124682078.1 | transposase | - |
C3Z06_RS32330 | 94750..95241 | + | 492 | WP_158664445.1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase | - |
C3Z06_RS32335 | 95251..96288 | + | 1038 | WP_024569647.1 | GIY-YIG nuclease family protein | - |
C3Z06_RS32340 | 96285..96812 | + | 528 | WP_024569646.1 | hypothetical protein | - |
C3Z06_RS32345 | 97308..97556 | + | 249 | WP_024569645.1 | antitoxin | Toxin |
C3Z06_RS32350 | 97550..97870 | + | 321 | WP_024569644.1 | type II toxin-antitoxin system PemK/MazF family toxin | Antitoxin |
C3Z06_RS32355 | 97946..99132 | + | 1187 | WP_085960481.1 | IS3-like element ISRme13 family transposase | - |
C3Z06_RS32365 | 99590..99829 | + | 240 | WP_024569642.1 | hypothetical protein | - |
C3Z06_RS32370 | 99842..100159 | + | 318 | WP_024569641.1 | hypothetical protein | - |
C3Z06_RS32375 | 100294..100605 | + | 312 | WP_024569640.1 | hypothetical protein | - |
C3Z06_RS33295 | 100626..100991 | + | 366 | WP_035835006.1 | hypothetical protein | - |
C3Z06_RS32380 | 101238..101444 | + | 207 | WP_024569639.1 | hypothetical protein | - |
C3Z06_RS32385 | 101566..102003 | + | 438 | WP_024569638.1 | hypothetical protein | - |
C3Z06_RS33300 | 102167..102448 | + | 282 | WP_152536340.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..180778 | 180778 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 83 a.a. Molecular weight: 8910.16 Da Isoelectric Point: 4.2463
>T95090 WP_024569645.1 NZ_CP026547:97308-97556 [Cupriavidus metallidurans]
MRVTIRRMGNSQGVLIPKPILAQLGLEDEVDMAVEDDTLVIRKPKKKAREGWAEASEAVAAAGDDALVMGEFSNADDAEL
VW
MRVTIRRMGNSQGVLIPKPILAQLGLEDEVDMAVEDDTLVIRKPKKKAREGWAEASEAVAAAGDDALVMGEFSNADDAEL
VW
Download Length: 249 bp
>T95090 NZ_CP026547:97308-97556 [Cupriavidus metallidurans]
ATGAGAGTAACGATTCGCAGAATGGGCAACTCGCAGGGGGTGCTAATCCCCAAACCGATCCTTGCCCAGCTTGGTTTGGA
GGATGAAGTGGACATGGCAGTTGAGGACGACACGCTGGTCATTCGCAAGCCTAAGAAGAAGGCGCGCGAGGGCTGGGCAG
AAGCCAGCGAAGCTGTCGCAGCGGCTGGCGACGACGCGCTGGTAATGGGCGAGTTTTCCAATGCCGATGACGCGGAGCTG
GTGTGGTAG
ATGAGAGTAACGATTCGCAGAATGGGCAACTCGCAGGGGGTGCTAATCCCCAAACCGATCCTTGCCCAGCTTGGTTTGGA
GGATGAAGTGGACATGGCAGTTGAGGACGACACGCTGGTCATTCGCAAGCCTAAGAAGAAGGCGCGCGAGGGCTGGGCAG
AAGCCAGCGAAGCTGTCGCAGCGGCTGGCGACGACGCGCTGGTAATGGGCGAGTTTTCCAATGCCGATGACGCGGAGCTG
GTGTGGTAG
Antitoxin
Download Length: 107 a.a. Molecular weight: 11725.96 Da Isoelectric Point: 10.7695
>AT95090 WP_024569644.1 NZ_CP026547:97550-97870 [Cupriavidus metallidurans]
VVARGEIWLVALDPTKGSEIQKTRPCVVISPPEMHDHLRTVIVAPMTTKGRAAPFRVPITFMRKNGLILLDQLRAVDKVR
LIKKAGAVADKTLLSTLQTLQEVFAE
VVARGEIWLVALDPTKGSEIQKTRPCVVISPPEMHDHLRTVIVAPMTTKGRAAPFRVPITFMRKNGLILLDQLRAVDKVR
LIKKAGAVADKTLLSTLQTLQEVFAE
Download Length: 321 bp
>AT95090 NZ_CP026547:97550-97870 [Cupriavidus metallidurans]
GTGGTAGCGCGCGGAGAGATTTGGCTGGTCGCTCTGGACCCGACAAAGGGCAGTGAGATTCAGAAGACGCGACCGTGCGT
GGTCATCTCGCCTCCGGAAATGCACGACCATTTGCGCACGGTGATCGTTGCGCCGATGACGACAAAGGGCCGGGCGGCAC
CGTTTCGTGTGCCTATCACCTTCATGCGCAAGAATGGACTGATTTTGCTAGATCAGCTTCGTGCAGTAGACAAGGTGCGC
TTGATCAAGAAGGCCGGCGCCGTTGCCGATAAGACGTTGTTGAGCACCCTGCAAACATTGCAGGAAGTCTTTGCAGAGTA
G
GTGGTAGCGCGCGGAGAGATTTGGCTGGTCGCTCTGGACCCGACAAAGGGCAGTGAGATTCAGAAGACGCGACCGTGCGT
GGTCATCTCGCCTCCGGAAATGCACGACCATTTGCGCACGGTGATCGTTGCGCCGATGACGACAAAGGGCCGGGCGGCAC
CGTTTCGTGTGCCTATCACCTTCATGCGCAAGAATGGACTGATTTTGCTAGATCAGCTTCGTGCAGTAGACAAGGTGCGC
TTGATCAAGAAGGCCGGCGCCGTTGCCGATAAGACGTTGTTGAGCACCCTGCAAACATTGCAGGAAGTCTTTGCAGAGTA
G
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A132H7S3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A132H6K9 |