Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/YafQ-RelB |
Location | 1919602..1920139 | Replicon | chromosome |
Accession | NZ_CP026544 | ||
Organism | Cupriavidus metallidurans strain Ni-2 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A2L0X163 |
Locus tag | C3Z06_RS09195 | Protein ID | WP_060986098.1 |
Coordinates | 1919858..1920139 (+) | Length | 94 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | A0A2L0X100 |
Locus tag | C3Z06_RS09190 | Protein ID | WP_060986097.1 |
Coordinates | 1919602..1919871 (+) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
C3Z06_RS09170 | 1915302..1916612 | - | 1311 | WP_024815560.1 | site-specific integrase | - |
C3Z06_RS32905 | 1916637..1916783 | - | 147 | WP_153587080.1 | hypothetical protein | - |
C3Z06_RS09175 | 1916918..1917538 | - | 621 | WP_054433628.1 | superoxide dismutase | - |
C3Z06_RS09180 | 1917538..1917858 | - | 321 | WP_174263136.1 | hypothetical protein | - |
C3Z06_RS09185 | 1918035..1919264 | - | 1230 | WP_158664393.1 | chromate transporter | - |
C3Z06_RS09190 | 1919602..1919871 | + | 270 | WP_060986097.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
C3Z06_RS09195 | 1919858..1920139 | + | 282 | WP_060986098.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
C3Z06_RS09200 | 1920355..1920927 | + | 573 | WP_009277700.1 | recombinase family protein | - |
C3Z06_RS09205 | 1920924..1921307 | + | 384 | WP_104669857.1 | hypothetical protein | - |
C3Z06_RS09210 | 1921355..1922086 | - | 732 | WP_104669858.1 | chromate resistance protein | - |
C3Z06_RS09215 | 1922085..1922354 | + | 270 | WP_104669859.1 | DUF2026 family protein | - |
C3Z06_RS09220 | 1922397..1923179 | + | 783 | WP_104669860.1 | TIGR02391 family protein | - |
C3Z06_RS09225 | 1923123..1924193 | - | 1071 | WP_005797778.1 | aminoglycoside phosphotransferase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | IScluster/Tn | - | - | 1910595..1920927 | 10332 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10657.05 Da Isoelectric Point: 9.0398
>T95088 WP_060986098.1 NZ_CP026544:1919858-1920139 [Cupriavidus metallidurans]
MRTIDRSSAFKRDFKREAKGQHRATLDDALKPVLLALATDQPLDARHRDHDLSGDWAGYRECHIKPDLLLIYRKSDSDTL
RLARLGSHSELFG
MRTIDRSSAFKRDFKREAKGQHRATLDDALKPVLLALATDQPLDARHRDHDLSGDWAGYRECHIKPDLLLIYRKSDSDTL
RLARLGSHSELFG
Download Length: 282 bp
>T95088 NZ_CP026544:1919858-1920139 [Cupriavidus metallidurans]
ATGCGGACGATTGATCGTTCGTCCGCGTTCAAGCGCGATTTCAAGCGCGAGGCCAAGGGACAGCACCGTGCCACGCTCGA
TGACGCGCTCAAGCCGGTGCTGCTCGCGCTGGCGACCGATCAGCCGTTGGACGCGCGCCACCGCGACCATGATCTTTCCG
GCGATTGGGCGGGCTACCGCGAGTGCCACATCAAGCCCGACCTGCTGCTGATTTACCGCAAGTCCGATTCCGACACTCTG
CGACTGGCGCGGCTTGGCTCGCATAGCGAGCTTTTCGGCTGA
ATGCGGACGATTGATCGTTCGTCCGCGTTCAAGCGCGATTTCAAGCGCGAGGCCAAGGGACAGCACCGTGCCACGCTCGA
TGACGCGCTCAAGCCGGTGCTGCTCGCGCTGGCGACCGATCAGCCGTTGGACGCGCGCCACCGCGACCATGATCTTTCCG
GCGATTGGGCGGGCTACCGCGAGTGCCACATCAAGCCCGACCTGCTGCTGATTTACCGCAAGTCCGATTCCGACACTCTG
CGACTGGCGCGGCTTGGCTCGCATAGCGAGCTTTTCGGCTGA
Antitoxin
Download Length: 90 a.a. Molecular weight: 9688.09 Da Isoelectric Point: 6.4667
>AT95088 WP_060986097.1 NZ_CP026544:1919602-1919871 [Cupriavidus metallidurans]
MSTTADTYVRARIDTNTKERAASALEAMGLSISDAIRLLMLRIADEHRLPFDVKVPNATTKKAIAELEAGKGKKFASVDN
LMADLHADD
MSTTADTYVRARIDTNTKERAASALEAMGLSISDAIRLLMLRIADEHRLPFDVKVPNATTKKAIAELEAGKGKKFASVDN
LMADLHADD
Download Length: 270 bp
>AT95088 NZ_CP026544:1919602-1919871 [Cupriavidus metallidurans]
ATGAGCACTACAGCCGACACCTACGTCCGCGCCCGCATCGACACCAACACCAAGGAACGCGCCGCCAGCGCACTCGAAGC
AATGGGCTTGTCGATTTCCGACGCCATCCGCCTGTTGATGCTGCGCATCGCCGATGAGCACCGCTTGCCTTTTGACGTGA
AGGTGCCCAACGCCACGACCAAAAAGGCGATTGCCGAACTGGAAGCGGGCAAGGGCAAGAAGTTCGCCAGCGTGGACAAC
CTAATGGCAGACCTGCATGCGGACGATTGA
ATGAGCACTACAGCCGACACCTACGTCCGCGCCCGCATCGACACCAACACCAAGGAACGCGCCGCCAGCGCACTCGAAGC
AATGGGCTTGTCGATTTCCGACGCCATCCGCCTGTTGATGCTGCGCATCGCCGATGAGCACCGCTTGCCTTTTGACGTGA
AGGTGCCCAACGCCACGACCAAAAAGGCGATTGCCGAACTGGAAGCGGGCAAGGGCAAGAAGTTCGCCAGCGTGGACAAC
CTAATGGCAGACCTGCATGCGGACGATTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2L0X163 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2L0X100 |