Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1919602..1920139 Replicon chromosome
Accession NZ_CP026544
Organism Cupriavidus metallidurans strain Ni-2

Toxin (Protein)


Gene name relE Uniprot ID A0A2L0X163
Locus tag C3Z06_RS09195 Protein ID WP_060986098.1
Coordinates 1919858..1920139 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2L0X100
Locus tag C3Z06_RS09190 Protein ID WP_060986097.1
Coordinates 1919602..1919871 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3Z06_RS09170 1915302..1916612 - 1311 WP_024815560.1 site-specific integrase -
C3Z06_RS32905 1916637..1916783 - 147 WP_153587080.1 hypothetical protein -
C3Z06_RS09175 1916918..1917538 - 621 WP_054433628.1 superoxide dismutase -
C3Z06_RS09180 1917538..1917858 - 321 WP_174263136.1 hypothetical protein -
C3Z06_RS09185 1918035..1919264 - 1230 WP_158664393.1 chromate transporter -
C3Z06_RS09190 1919602..1919871 + 270 WP_060986097.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
C3Z06_RS09195 1919858..1920139 + 282 WP_060986098.1 type II toxin-antitoxin system YafQ family toxin Toxin
C3Z06_RS09200 1920355..1920927 + 573 WP_009277700.1 recombinase family protein -
C3Z06_RS09205 1920924..1921307 + 384 WP_104669857.1 hypothetical protein -
C3Z06_RS09210 1921355..1922086 - 732 WP_104669858.1 chromate resistance protein -
C3Z06_RS09215 1922085..1922354 + 270 WP_104669859.1 DUF2026 family protein -
C3Z06_RS09220 1922397..1923179 + 783 WP_104669860.1 TIGR02391 family protein -
C3Z06_RS09225 1923123..1924193 - 1071 WP_005797778.1 aminoglycoside phosphotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 1910595..1920927 10332


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(8-82)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10657.05 Da        Isoelectric Point: 9.0398

>T95088 WP_060986098.1 NZ_CP026544:1919858-1920139 [Cupriavidus metallidurans]
MRTIDRSSAFKRDFKREAKGQHRATLDDALKPVLLALATDQPLDARHRDHDLSGDWAGYRECHIKPDLLLIYRKSDSDTL
RLARLGSHSELFG

Download         Length: 282 bp

>T95088 NZ_CP026544:1919858-1920139 [Cupriavidus metallidurans]
ATGCGGACGATTGATCGTTCGTCCGCGTTCAAGCGCGATTTCAAGCGCGAGGCCAAGGGACAGCACCGTGCCACGCTCGA
TGACGCGCTCAAGCCGGTGCTGCTCGCGCTGGCGACCGATCAGCCGTTGGACGCGCGCCACCGCGACCATGATCTTTCCG
GCGATTGGGCGGGCTACCGCGAGTGCCACATCAAGCCCGACCTGCTGCTGATTTACCGCAAGTCCGATTCCGACACTCTG
CGACTGGCGCGGCTTGGCTCGCATAGCGAGCTTTTCGGCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9688.09 Da        Isoelectric Point: 6.4667

>AT95088 WP_060986097.1 NZ_CP026544:1919602-1919871 [Cupriavidus metallidurans]
MSTTADTYVRARIDTNTKERAASALEAMGLSISDAIRLLMLRIADEHRLPFDVKVPNATTKKAIAELEAGKGKKFASVDN
LMADLHADD

Download         Length: 270 bp

>AT95088 NZ_CP026544:1919602-1919871 [Cupriavidus metallidurans]
ATGAGCACTACAGCCGACACCTACGTCCGCGCCCGCATCGACACCAACACCAAGGAACGCGCCGCCAGCGCACTCGAAGC
AATGGGCTTGTCGATTTCCGACGCCATCCGCCTGTTGATGCTGCGCATCGCCGATGAGCACCGCTTGCCTTTTGACGTGA
AGGTGCCCAACGCCACGACCAAAAAGGCGATTGCCGAACTGGAAGCGGGCAAGGGCAAGAAGTTCGCCAGCGTGGACAAC
CTAATGGCAGACCTGCATGCGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L0X163

Antitoxin

Source ID Structure
AlphaFold DB A0A2L0X100

References