Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-HicB |
Location | 1282127..1282740 | Replicon | chromosome |
Accession | NZ_CP026544 | ||
Organism | Cupriavidus metallidurans strain Ni-2 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | Q1LPG3 |
Locus tag | C3Z06_RS06105 | Protein ID | WP_011515865.1 |
Coordinates | 1282561..1282740 (-) | Length | 60 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | L2EG10 |
Locus tag | C3Z06_RS06100 | Protein ID | WP_008647764.1 |
Coordinates | 1282127..1282531 (-) | Length | 135 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
C3Z06_RS06085 | 1277517..1278050 | + | 534 | WP_029308195.1 | peptidylprolyl isomerase | - |
C3Z06_RS06090 | 1278145..1279197 | - | 1053 | WP_011515862.1 | hypothetical protein | - |
C3Z06_RS06095 | 1279194..1281800 | - | 2607 | WP_035832936.1 | DNA mismatch repair protein MutS | - |
C3Z06_RS06100 | 1282127..1282531 | - | 405 | WP_008647764.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
C3Z06_RS06105 | 1282561..1282740 | - | 180 | WP_011515865.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
C3Z06_RS06110 | 1282944..1283765 | - | 822 | WP_017513083.1 | inositol monophosphatase | - |
C3Z06_RS06115 | 1283993..1284862 | + | 870 | WP_029308191.1 | RNA methyltransferase | - |
C3Z06_RS06120 | 1285191..1285934 | + | 744 | WP_029308190.1 | serine O-acetyltransferase | - |
C3Z06_RS06125 | 1285983..1286774 | - | 792 | WP_029308189.1 | UDP-2,3-diacylglucosamine diphosphatase | - |
C3Z06_RS06130 | 1286843..1287343 | - | 501 | WP_011515870.1 | peptidyl-prolyl cis-trans isomerase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 60 a.a. Molecular weight: 6790.07 Da Isoelectric Point: 12.3707
>T95087 WP_011515865.1 NZ_CP026544:c1282740-1282561 [Cupriavidus metallidurans]
MHSSTLIRLLEQKGWKLVRTHGSHFTFKHPRHMLIVTVPHPKKDLPTGTVRNILRTAGL
MHSSTLIRLLEQKGWKLVRTHGSHFTFKHPRHMLIVTVPHPKKDLPTGTVRNILRTAGL
Download Length: 180 bp
>T95087 NZ_CP026544:c1282740-1282561 [Cupriavidus metallidurans]
TTGCATTCGTCCACGCTGATCCGATTGCTCGAACAGAAGGGGTGGAAGCTGGTGCGCACGCATGGCAGTCATTTCACCTT
CAAACATCCGCGGCACATGCTGATTGTGACCGTGCCCCATCCGAAGAAGGATCTGCCGACAGGCACGGTCCGAAACATTC
TGAGGACGGCCGGACTATGA
TTGCATTCGTCCACGCTGATCCGATTGCTCGAACAGAAGGGGTGGAAGCTGGTGCGCACGCATGGCAGTCATTTCACCTT
CAAACATCCGCGGCACATGCTGATTGTGACCGTGCCCCATCCGAAGAAGGATCTGCCGACAGGCACGGTCCGAAACATTC
TGAGGACGGCCGGACTATGA
Antitoxin
Download Length: 135 a.a. Molecular weight: 14530.73 Da Isoelectric Point: 5.1814
>AT95087 WP_008647764.1 NZ_CP026544:c1282531-1282127 [Cupriavidus metallidurans]
MDFPIAIHKDANSVYGVTVPDVAGCYSAGESIEEAVRNAREAITTHVVALLSLGEEVVLKATPIGTLMAQPEYAGAIWAL
ADIDMSKLDARPERINISLPRFVLHKIDMFVERRHETRSGFLARVALDAIAGSV
MDFPIAIHKDANSVYGVTVPDVAGCYSAGESIEEAVRNAREAITTHVVALLSLGEEVVLKATPIGTLMAQPEYAGAIWAL
ADIDMSKLDARPERINISLPRFVLHKIDMFVERRHETRSGFLARVALDAIAGSV
Download Length: 405 bp
>AT95087 NZ_CP026544:c1282531-1282127 [Cupriavidus metallidurans]
ATGGACTTTCCCATTGCCATTCACAAGGATGCGAACTCGGTCTACGGCGTGACGGTGCCCGATGTGGCGGGCTGTTACTC
CGCCGGCGAATCGATCGAGGAAGCGGTCCGCAATGCACGCGAGGCCATCACGACTCACGTGGTGGCGCTGCTCTCCCTTG
GCGAGGAGGTTGTTCTGAAAGCGACGCCGATCGGCACGCTGATGGCCCAACCGGAGTACGCAGGCGCGATCTGGGCGCTG
GCCGACATCGACATGAGCAAGCTCGACGCACGCCCGGAGCGAATCAATATCAGCCTACCTCGTTTTGTATTGCACAAGAT
CGACATGTTCGTGGAACGTCGCCACGAAACCCGGAGCGGGTTCCTCGCGCGCGTCGCGCTGGACGCCATCGCGGGCAGCG
TCTGA
ATGGACTTTCCCATTGCCATTCACAAGGATGCGAACTCGGTCTACGGCGTGACGGTGCCCGATGTGGCGGGCTGTTACTC
CGCCGGCGAATCGATCGAGGAAGCGGTCCGCAATGCACGCGAGGCCATCACGACTCACGTGGTGGCGCTGCTCTCCCTTG
GCGAGGAGGTTGTTCTGAAAGCGACGCCGATCGGCACGCTGATGGCCCAACCGGAGTACGCAGGCGCGATCTGGGCGCTG
GCCGACATCGACATGAGCAAGCTCGACGCACGCCCGGAGCGAATCAATATCAGCCTACCTCGTTTTGTATTGCACAAGAT
CGACATGTTCGTGGAACGTCGCCACGAAACCCGGAGCGGGTTCCTCGCGCGCGTCGCGCTGGACGCCATCGCGGGCAGCG
TCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2L0WZI7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2L0WZG6 |