Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1282127..1282740 Replicon chromosome
Accession NZ_CP026544
Organism Cupriavidus metallidurans strain Ni-2

Toxin (Protein)


Gene name hicA Uniprot ID Q1LPG3
Locus tag C3Z06_RS06105 Protein ID WP_011515865.1
Coordinates 1282561..1282740 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L2EG10
Locus tag C3Z06_RS06100 Protein ID WP_008647764.1
Coordinates 1282127..1282531 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3Z06_RS06085 1277517..1278050 + 534 WP_029308195.1 peptidylprolyl isomerase -
C3Z06_RS06090 1278145..1279197 - 1053 WP_011515862.1 hypothetical protein -
C3Z06_RS06095 1279194..1281800 - 2607 WP_035832936.1 DNA mismatch repair protein MutS -
C3Z06_RS06100 1282127..1282531 - 405 WP_008647764.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C3Z06_RS06105 1282561..1282740 - 180 WP_011515865.1 type II toxin-antitoxin system HicA family toxin Toxin
C3Z06_RS06110 1282944..1283765 - 822 WP_017513083.1 inositol monophosphatase -
C3Z06_RS06115 1283993..1284862 + 870 WP_029308191.1 RNA methyltransferase -
C3Z06_RS06120 1285191..1285934 + 744 WP_029308190.1 serine O-acetyltransferase -
C3Z06_RS06125 1285983..1286774 - 792 WP_029308189.1 UDP-2,3-diacylglucosamine diphosphatase -
C3Z06_RS06130 1286843..1287343 - 501 WP_011515870.1 peptidyl-prolyl cis-trans isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6790.07 Da        Isoelectric Point: 12.3707

>T95087 WP_011515865.1 NZ_CP026544:c1282740-1282561 [Cupriavidus metallidurans]
MHSSTLIRLLEQKGWKLVRTHGSHFTFKHPRHMLIVTVPHPKKDLPTGTVRNILRTAGL

Download         Length: 180 bp

>T95087 NZ_CP026544:c1282740-1282561 [Cupriavidus metallidurans]
TTGCATTCGTCCACGCTGATCCGATTGCTCGAACAGAAGGGGTGGAAGCTGGTGCGCACGCATGGCAGTCATTTCACCTT
CAAACATCCGCGGCACATGCTGATTGTGACCGTGCCCCATCCGAAGAAGGATCTGCCGACAGGCACGGTCCGAAACATTC
TGAGGACGGCCGGACTATGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14530.73 Da        Isoelectric Point: 5.1814

>AT95087 WP_008647764.1 NZ_CP026544:c1282531-1282127 [Cupriavidus metallidurans]
MDFPIAIHKDANSVYGVTVPDVAGCYSAGESIEEAVRNAREAITTHVVALLSLGEEVVLKATPIGTLMAQPEYAGAIWAL
ADIDMSKLDARPERINISLPRFVLHKIDMFVERRHETRSGFLARVALDAIAGSV

Download         Length: 405 bp

>AT95087 NZ_CP026544:c1282531-1282127 [Cupriavidus metallidurans]
ATGGACTTTCCCATTGCCATTCACAAGGATGCGAACTCGGTCTACGGCGTGACGGTGCCCGATGTGGCGGGCTGTTACTC
CGCCGGCGAATCGATCGAGGAAGCGGTCCGCAATGCACGCGAGGCCATCACGACTCACGTGGTGGCGCTGCTCTCCCTTG
GCGAGGAGGTTGTTCTGAAAGCGACGCCGATCGGCACGCTGATGGCCCAACCGGAGTACGCAGGCGCGATCTGGGCGCTG
GCCGACATCGACATGAGCAAGCTCGACGCACGCCCGGAGCGAATCAATATCAGCCTACCTCGTTTTGTATTGCACAAGAT
CGACATGTTCGTGGAACGTCGCCACGAAACCCGGAGCGGGTTCCTCGCGCGCGTCGCGCTGGACGCCATCGCGGGCAGCG
TCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L0WZI7

Antitoxin

Source ID Structure
AlphaFold DB A0A2L0WZG6

References