Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3895433..3896025 Replicon chromosome
Accession NZ_CP026538
Organism Desulfovibrio carbinolicus strain DSM 3852

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag C3Y92_RS17380 Protein ID WP_129354701.1
Coordinates 3895433..3895687 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag C3Y92_RS17385 Protein ID WP_129354703.1
Coordinates 3895684..3896025 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3Y92_RS17365 3891268..3892413 + 1146 WP_129354695.1 Flp pilus assembly complex ATPase component TadA -
C3Y92_RS17370 3892541..3893434 + 894 WP_129354697.1 LytTR family DNA-binding domain-containing protein -
C3Y92_RS17375 3893467..3895374 + 1908 WP_129354699.1 acetate--CoA ligase -
C3Y92_RS17380 3895433..3895687 + 255 WP_129354701.1 type II toxin-antitoxin system HicA family toxin Toxin
C3Y92_RS17385 3895684..3896025 + 342 WP_129354703.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C3Y92_RS17390 3896283..3896696 - 414 WP_012750229.1 hypothetical protein -
C3Y92_RS17395 3896907..3898184 + 1278 WP_129354705.1 2-hydroxyacyl-CoA dehydratase family protein -
C3Y92_RS17400 3898181..3898939 + 759 WP_129354707.1 3-hydroxyacyl-ACP dehydratase -
C3Y92_RS17405 3899259..3900728 + 1470 WP_129354709.1 outer membrane homotrimeric porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9196.69 Da        Isoelectric Point: 11.9644

>T95085 WP_129354701.1 NZ_CP026538:3895433-3895687 [Desulfovibrio carbinolicus]
MNAKARKTLTAIFSDPVRSDFGWDEIEALFRALGADIRQGRGSRIRVALAGQTAVFHRPHPRPTLLKAAVKDLRAFLTSA
GVIP

Download         Length: 255 bp

>T95085 NZ_CP026538:3895433-3895687 [Desulfovibrio carbinolicus]
ATGAACGCCAAGGCCCGTAAAACCCTGACCGCCATCTTTTCCGATCCGGTCAGATCGGATTTTGGCTGGGACGAGATTGA
AGCGCTGTTTCGGGCTCTTGGGGCGGATATCCGCCAGGGACGAGGTTCGCGTATTCGCGTTGCCCTCGCCGGACAGACAG
CCGTATTCCATCGTCCCCACCCACGCCCCACGTTGCTCAAAGCCGCCGTCAAAGACCTGCGCGCCTTTCTAACAAGCGCC
GGAGTAATCCCATGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12609.23 Da        Isoelectric Point: 5.2248

>AT95085 WP_129354703.1 NZ_CP026538:3895684-3896025 [Desulfovibrio carbinolicus]
MNIMKYKDFIGEFEYDAEAKFFHGRVVNIRDTVTFEGASASELEQALADSVEDYLEFCRDLGREPDKPFSGKFNIRLTPQ
SHRLVATAAKACGKSLNAFAAEALERQARAVLG

Download         Length: 342 bp

>AT95085 NZ_CP026538:3895684-3896025 [Desulfovibrio carbinolicus]
ATGAACATCATGAAATACAAGGACTTCATTGGCGAATTCGAATACGACGCCGAAGCCAAATTCTTCCACGGCCGCGTGGT
CAATATCCGCGACACCGTGACCTTCGAAGGAGCCTCGGCCAGCGAACTCGAACAGGCGCTGGCTGATTCCGTGGAAGATT
ATCTGGAATTTTGCCGCGACCTCGGCCGCGAGCCAGACAAGCCGTTTTCCGGCAAATTCAATATCCGCCTGACGCCCCAG
TCCCACCGACTGGTGGCGACCGCCGCCAAGGCCTGCGGCAAAAGCCTCAACGCCTTCGCCGCCGAAGCCCTGGAACGCCA
GGCCCGGGCCGTGCTCGGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References