Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3440648..3441222 Replicon chromosome
Accession NZ_CP026538
Organism Desulfovibrio carbinolicus strain DSM 3852

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag C3Y92_RS15415 Protein ID WP_129353988.1
Coordinates 3440890..3441222 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag C3Y92_RS15410 Protein ID WP_129353986.1
Coordinates 3440648..3440893 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3Y92_RS15400 3436580..3439279 + 2700 WP_129353982.1 bifunctional acetate--CoA ligase family protein/GNAT family N-acetyltransferase -
C3Y92_RS15405 3439276..3440355 + 1080 WP_129353984.1 HD domain-containing protein -
C3Y92_RS15410 3440648..3440893 + 246 WP_129353986.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
C3Y92_RS15415 3440890..3441222 + 333 WP_129353988.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
C3Y92_RS15420 3441357..3441845 - 489 WP_129353990.1 ribonuclease HI -
C3Y92_RS15425 3441842..3442363 - 522 WP_129353992.1 TPM domain-containing protein -
C3Y92_RS15430 3442360..3443046 - 687 WP_129353994.1 ABC transporter ATP-binding protein -
C3Y92_RS15435 3443162..3443755 + 594 WP_129353996.1 arylesterase -
C3Y92_RS15440 3443761..3444552 + 792 WP_129353998.1 type III pantothenate kinase -
C3Y92_RS15445 3444549..3445280 + 732 WP_207214000.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-108)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12149.77 Da        Isoelectric Point: 7.2754

>T95084 WP_129353988.1 NZ_CP026538:3440890-3441222 [Desulfovibrio carbinolicus]
VREYPERGDFVHLDFDPKAGHEQGGPRFGLVLSPGVYNKASGLAIVAPITSRQKGYPFEAPIPDGERCYGVVLADHTRSI
DWRARDVKIVGQASQALVEDVLARYRTLLT

Download         Length: 333 bp

>T95084 NZ_CP026538:3440890-3441222 [Desulfovibrio carbinolicus]
GTGAGGGAGTATCCGGAGCGAGGCGATTTCGTCCACCTCGACTTCGATCCCAAGGCCGGCCACGAACAGGGCGGCCCCCG
GTTCGGCCTTGTGCTCTCGCCCGGCGTCTACAACAAGGCATCCGGCCTGGCCATCGTGGCCCCCATCACCAGCCGGCAAA
AAGGCTATCCCTTTGAAGCGCCCATCCCCGATGGCGAGCGGTGTTACGGCGTGGTGCTGGCCGACCACACGCGCAGCATC
GACTGGCGGGCCAGAGACGTGAAAATCGTGGGGCAGGCGTCCCAGGCCCTCGTCGAGGATGTCCTGGCGCGCTATCGCAC
GTTGCTGACCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8796.92 Da        Isoelectric Point: 5.7904

>AT95084 WP_129353986.1 NZ_CP026538:3440648-3440893 [Desulfovibrio carbinolicus]
VETVLAKWGNSLGVRIPKAMAADAGLDAGDAVSITQSAEGIVIKKAQPKPQYRLADLVSRITDENRHEATDWGQPQGREI
W

Download         Length: 246 bp

>AT95084 NZ_CP026538:3440648-3440893 [Desulfovibrio carbinolicus]
GTGGAAACAGTCTTGGCGAAATGGGGAAACAGCCTGGGCGTACGCATTCCCAAGGCCATGGCCGCCGACGCAGGGCTGGA
CGCCGGCGACGCCGTCAGCATCACCCAATCCGCGGAAGGGATCGTGATCAAAAAGGCGCAGCCCAAACCGCAATACCGTC
TGGCCGATCTGGTCAGCCGGATCACGGACGAGAACAGGCATGAGGCCACGGATTGGGGCCAGCCCCAGGGCAGGGAAATC
TGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References