Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 609792..610327 Replicon chromosome
Accession NZ_CP026538
Organism Desulfovibrio carbinolicus strain DSM 3852

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag C3Y92_RS02720 Protein ID WP_129349260.1
Coordinates 610001..610327 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag C3Y92_RS02715 Protein ID WP_129349258.1
Coordinates 609792..610004 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3Y92_RS02680 604912..605295 + 384 WP_015862630.1 response regulator -
C3Y92_RS02685 605295..606014 + 720 WP_129349248.1 hypothetical protein -
C3Y92_RS02690 606027..606479 + 453 WP_015862628.1 response regulator -
C3Y92_RS02695 606561..607646 + 1086 WP_129349250.1 hybrid sensor histidine kinase/response regulator -
C3Y92_RS02700 607821..608189 + 369 WP_129349252.1 hypothetical protein -
C3Y92_RS02705 608329..609183 - 855 WP_129349254.1 SDR family oxidoreductase -
C3Y92_RS02710 609285..609698 + 414 WP_129349256.1 helix-turn-helix transcriptional regulator -
C3Y92_RS02715 609792..610004 + 213 WP_129349258.1 antitoxin MazE family protein Antitoxin
C3Y92_RS02720 610001..610327 + 327 WP_129349260.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
C3Y92_RS02725 610462..611700 - 1239 WP_129349262.1 serine hydroxymethyltransferase -
C3Y92_RS02730 611795..613039 - 1245 WP_129349264.1 beta-ketoacyl-ACP synthase II -
C3Y92_RS02735 613112..613348 - 237 WP_006917960.1 acyl carrier protein -
C3Y92_RS02740 613379..614107 - 729 WP_129349266.1 3-oxoacyl-[acyl-carrier-protein] reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-104)

Antitoxin

Antitoxin MazE-like

(9-69)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11482.38 Da        Isoelectric Point: 9.9220

>T95083 WP_129349260.1 NZ_CP026538:610001-610327 [Desulfovibrio carbinolicus]
MKRGDVVTVSLAGDYGKPRPALVIQSDLFAEHASVTLLPITSHRVDGAPLLRFDVAANAANGLRKPSQVMIDKAHTVPRD
KVGAPFGRLDDGLMLEITRALSVLLGIA

Download         Length: 327 bp

>T95083 NZ_CP026538:610001-610327 [Desulfovibrio carbinolicus]
ATGAAACGCGGCGACGTGGTGACCGTTTCCCTGGCCGGCGACTACGGGAAGCCGCGCCCGGCCCTGGTCATCCAGTCCGA
TCTGTTTGCCGAACACGCTTCGGTGACGCTGTTGCCCATTACCAGCCACCGGGTGGACGGCGCGCCCTTGCTGCGTTTTG
ACGTTGCCGCAAACGCGGCGAACGGACTGCGCAAACCCTCCCAAGTCATGATCGACAAGGCCCATACCGTGCCGCGCGAC
AAGGTTGGCGCGCCCTTTGGCCGCCTGGATGACGGGCTGATGCTGGAAATCACCCGGGCGCTTTCAGTCTTATTGGGGAT
CGCCTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 8049.96 Da        Isoelectric Point: 7.1663

>AT95083 WP_129349258.1 NZ_CP026538:609792-610004 [Desulfovibrio carbinolicus]
MQASTTKQERYRARLREQGLRPLQIWVPDTRRPGFAAECRRQSQLVSSDPHEAEHLDFAAQAAATIEGWE

Download         Length: 213 bp

>AT95083 NZ_CP026538:609792-610004 [Desulfovibrio carbinolicus]
ATGCAAGCCTCAACCACCAAGCAGGAGCGGTACAGAGCCAGACTGCGCGAGCAGGGACTGCGGCCGCTGCAGATATGGGT
TCCCGACACGCGCCGGCCCGGTTTCGCCGCCGAGTGCCGGCGGCAGTCCCAGCTTGTGAGCAGTGATCCCCACGAAGCGG
AGCATCTGGATTTTGCCGCCCAGGCCGCCGCGACCATCGAAGGGTGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References