Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 677100..677638 Replicon chromosome
Accession NZ_CP026532
Organism Vibrio cholerae strain FORC_076

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag FORC76_RS17415 Protein ID WP_000802136.1
Coordinates 677339..677638 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag FORC76_RS17410 Protein ID WP_001107719.1
Coordinates 677100..677342 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC76_RS17355 672182..672556 - 375 WP_001221132.1 hypothetical protein -
FORC76_RS17360 672679..673143 - 465 WP_032480879.1 hypothetical protein -
FORC76_RS19295 673153..673224 - 72 Protein_656 acetyltransferase -
FORC76_RS17365 673293..673970 - 678 WP_002033254.1 FMN-binding negative transcriptional regulator -
FORC76_RS19300 674120..674216 - 97 Protein_658 DUF645 family protein -
FORC76_RS17380 674662..674904 + 243 WP_001961623.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FORC76_RS17385 674923..675240 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
FORC76_RS17390 675376..676149 - 774 WP_032467761.1 aminoglycoside phosphotransferase family protein -
FORC76_RS17395 676348..676593 + 246 WP_001260801.1 type II toxin-antitoxin system CcdA family antitoxin -
FORC76_RS17400 676593..676910 + 318 WP_032480890.1 CcdB family protein -
FORC76_RS17410 677100..677342 + 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FORC76_RS17415 677339..677638 + 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORC76_RS19305 677815..677911 - 97 Protein_666 DUF645 family protein -
FORC76_RS17435 678319..678357 - 39 WP_128974310.1 hypothetical protein -
FORC76_RS17440 678376..678501 - 126 WP_080006744.1 DUF645 family protein -
FORC76_RS17445 678857..679038 - 182 Protein_669 DUF645 family protein -
FORC76_RS17455 679827..680321 - 495 WP_000573470.1 GNAT family N-acetyltransferase -
FORC76_RS17465 680515..680553 - 39 WP_128974310.1 hypothetical protein -
FORC76_RS17470 680572..680697 - 126 WP_080006744.1 DUF645 family protein -
FORC76_RS17485 681500..682009 - 510 WP_032474043.1 ClbS/DfsB family four-helix bundle protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island blaCARB-9 - 564019..691460 127441
- inside Integron - - 566037..688204 122167


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T95071 WP_000802136.1 NZ_CP026532:677339-677638 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T95071 NZ_CP026532:677339-677638 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT95071 WP_001107719.1 NZ_CP026532:677100-677342 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT95071 NZ_CP026532:677100-677342 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGACGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
PDB 7R5A
PDB 7B22
AlphaFold DB A0A151JFU4

References