Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 677100..677638 | Replicon | chromosome |
| Accession | NZ_CP026532 | ||
| Organism | Vibrio cholerae strain FORC_076 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | Q9KMJ0 |
| Locus tag | FORC76_RS17415 | Protein ID | WP_000802136.1 |
| Coordinates | 677339..677638 (+) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P58093 |
| Locus tag | FORC76_RS17410 | Protein ID | WP_001107719.1 |
| Coordinates | 677100..677342 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FORC76_RS17355 | 672182..672556 | - | 375 | WP_001221132.1 | hypothetical protein | - |
| FORC76_RS17360 | 672679..673143 | - | 465 | WP_032480879.1 | hypothetical protein | - |
| FORC76_RS19295 | 673153..673224 | - | 72 | Protein_656 | acetyltransferase | - |
| FORC76_RS17365 | 673293..673970 | - | 678 | WP_002033254.1 | FMN-binding negative transcriptional regulator | - |
| FORC76_RS19300 | 674120..674216 | - | 97 | Protein_658 | DUF645 family protein | - |
| FORC76_RS17380 | 674662..674904 | + | 243 | WP_001961623.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| FORC76_RS17385 | 674923..675240 | + | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| FORC76_RS17390 | 675376..676149 | - | 774 | WP_032467761.1 | aminoglycoside phosphotransferase family protein | - |
| FORC76_RS17395 | 676348..676593 | + | 246 | WP_001260801.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| FORC76_RS17400 | 676593..676910 | + | 318 | WP_032480890.1 | CcdB family protein | - |
| FORC76_RS17410 | 677100..677342 | + | 243 | WP_001107719.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| FORC76_RS17415 | 677339..677638 | + | 300 | WP_000802136.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FORC76_RS19305 | 677815..677911 | - | 97 | Protein_666 | DUF645 family protein | - |
| FORC76_RS17435 | 678319..678357 | - | 39 | WP_128974310.1 | hypothetical protein | - |
| FORC76_RS17440 | 678376..678501 | - | 126 | WP_080006744.1 | DUF645 family protein | - |
| FORC76_RS17445 | 678857..679038 | - | 182 | Protein_669 | DUF645 family protein | - |
| FORC76_RS17455 | 679827..680321 | - | 495 | WP_000573470.1 | GNAT family N-acetyltransferase | - |
| FORC76_RS17465 | 680515..680553 | - | 39 | WP_128974310.1 | hypothetical protein | - |
| FORC76_RS17470 | 680572..680697 | - | 126 | WP_080006744.1 | DUF645 family protein | - |
| FORC76_RS17485 | 681500..682009 | - | 510 | WP_032474043.1 | ClbS/DfsB family four-helix bundle protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | blaCARB-9 | - | 564019..691460 | 127441 | |
| - | inside | Integron | - | - | 566037..688204 | 122167 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11589.29 Da Isoelectric Point: 9.9232
>T95071 WP_000802136.1 NZ_CP026532:677339-677638 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA
Download Length: 300 bp
>T95071 NZ_CP026532:677339-677638 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8964.84 Da Isoelectric Point: 4.1677
>AT95071 WP_001107719.1 NZ_CP026532:677100-677342 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
Download Length: 243 bp
>AT95071 NZ_CP026532:677100-677342 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGACGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGACGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|