Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-Phd |
| Location | 674662..675240 | Replicon | chromosome |
| Accession | NZ_CP026532 | ||
| Organism | Vibrio cholerae strain FORC_076 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | O68848 |
| Locus tag | FORC76_RS17385 | Protein ID | WP_001180243.1 |
| Coordinates | 674923..675240 (+) | Length | 106 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | - |
| Locus tag | FORC76_RS17380 | Protein ID | WP_001961623.1 |
| Coordinates | 674662..674904 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FORC76_RS17330 | 670048..670218 | - | 171 | WP_001080654.1 | hypothetical protein | - |
| FORC76_RS17340 | 670531..670809 | - | 279 | WP_080285018.1 | DUF3709 domain-containing protein | - |
| FORC76_RS17345 | 671096..671278 | - | 183 | WP_032480896.1 | DUF645 family protein | - |
| FORC76_RS17350 | 671574..672062 | - | 489 | Protein_653 | dual specificity protein phosphatase family protein | - |
| FORC76_RS17355 | 672182..672556 | - | 375 | WP_001221132.1 | hypothetical protein | - |
| FORC76_RS17360 | 672679..673143 | - | 465 | WP_032480879.1 | hypothetical protein | - |
| FORC76_RS19295 | 673153..673224 | - | 72 | Protein_656 | acetyltransferase | - |
| FORC76_RS17365 | 673293..673970 | - | 678 | WP_002033254.1 | FMN-binding negative transcriptional regulator | - |
| FORC76_RS19300 | 674120..674216 | - | 97 | Protein_658 | DUF645 family protein | - |
| FORC76_RS17380 | 674662..674904 | + | 243 | WP_001961623.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| FORC76_RS17385 | 674923..675240 | + | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FORC76_RS17390 | 675376..676149 | - | 774 | WP_032467761.1 | aminoglycoside phosphotransferase family protein | - |
| FORC76_RS17395 | 676348..676593 | + | 246 | WP_001260801.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| FORC76_RS17400 | 676593..676910 | + | 318 | WP_032480890.1 | CcdB family protein | - |
| FORC76_RS17410 | 677100..677342 | + | 243 | WP_001107719.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| FORC76_RS17415 | 677339..677638 | + | 300 | WP_000802136.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| FORC76_RS19305 | 677815..677911 | - | 97 | Protein_666 | DUF645 family protein | - |
| FORC76_RS17435 | 678319..678357 | - | 39 | WP_128974310.1 | hypothetical protein | - |
| FORC76_RS17440 | 678376..678501 | - | 126 | WP_080006744.1 | DUF645 family protein | - |
| FORC76_RS17445 | 678857..679038 | - | 182 | Protein_669 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | blaCARB-9 | - | 564019..691460 | 127441 | |
| - | inside | Integron | - | - | 566037..688204 | 122167 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12158.97 Da Isoelectric Point: 9.7495
>T95070 WP_001180243.1 NZ_CP026532:674923-675240 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
Download Length: 318 bp
>T95070 NZ_CP026532:674923-675240 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTAGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTAGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 8931.22 Da Isoelectric Point: 5.6630
>AT95070 WP_001961623.1 NZ_CP026532:674662-674904 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDGGKTVDGATFLNTL
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDGGKTVDGATFLNTL
Download Length: 243 bp
>AT95070 NZ_CP026532:674662-674904 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATGGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATGGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|