Detailed information of TA system TA095067

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 656311..656851
• Replicon: chromosome
• Accession: NZ_CP026532
• Organism: Vibrio cholerae strain FORC_076

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FORC76_RS17185
• Protein ID: WP_002033296.1
• Coordinates: 656582..656851 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1T4SKS5
• Locus tag: FORC76_RS17180
• Protein ID: WP_032480862.1
• Coordinates: 656311..656589 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC76_RS17130	651859..652290	-	432	WP_002033387.1	GNAT family N-acetyltransferase	-
FORC76_RS17135	652630..652863	-	234	WP_080281227.1	DUF3709 domain-containing protein	-
FORC76_RS17140	652860..653044	-	185	Protein_619	DUF3709 domain-containing protein	-
FORC76_RS17145	653155..654126	-	972	WP_002033381.1	immunity 49 family protein	-
FORC76_RS17150	654476..654754	-	279	WP_029628768.1	DUF3709 domain-containing protein	-
FORC76_RS17155	655112..655435	-	324	WP_080281225.1	DUF3709 domain-containing protein	-
FORC76_RS17165	655749..655967	-	219	WP_164971225.1	DUF3709 domain-containing protein	-
FORC76_RS17170	656003..656154	-	152	Protein_624	DUF3709 domain-containing protein	-
FORC76_RS17180	656311..656589	+	279	WP_032480862.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FORC76_RS17185	656582..656851	+	270	WP_002033296.1	type II toxin-antitoxin system YafQ family toxin	Toxin
FORC76_RS17195	656986..657654	-	669	WP_002029672.1	hypothetical protein	-
FORC76_RS17200	657995..658219	-	225	WP_164971226.1	DUF3709 domain-containing protein	-
FORC76_RS17205	658447..658881	-	435	WP_002029791.1	GNAT family N-acetyltransferase	-
FORC76_RS17210	659022..659516	-	495	WP_084998624.1	GNAT family N-acetyltransferase	-
FORC76_RS17215	659652..660230	-	579	WP_001020574.1	DJ-1/PfpI family protein	-
FORC76_RS17220	660449..660679	+	231	WP_000838533.1	PAS factor family protein	-
FORC76_RS17225	660863..661780	-	918	WP_000834916.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	blaCARB-9	-	564019..691460	127441
	-	inside	Integron	-	-	566037..688204	122167

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-85)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10308.95 Da
• Isoelectric Point: 8.0487

>T95067 WP_002033296.1 NZ_CP026532:656582-656851 [Vibrio cholerae]
MYSLEYSTQFKKDFKKITKMPISDIIEVGNIISKLQRGEKLDPKNVDHPLTGGWVGFRDCHVKPDLVLIYRIFDDQLQLA
RIGSHSDLF

Nucleotide

• Length: 270 bp

>T95067 NZ_CP026532:656582-656851 [Vibrio cholerae]
ATGTATAGCTTAGAATATTCAACACAATTCAAAAAAGACTTCAAAAAAATCACCAAAATGCCGATTTCGGACATCATTGA
AGTCGGCAACATCATATCAAAGCTGCAAAGAGGCGAAAAACTCGACCCTAAAAATGTTGATCACCCTTTAACTGGCGGAT
GGGTTGGATTCCGTGACTGCCATGTTAAACCAGATCTAGTGCTCATTTATCGCATTTTTGATGACCAGCTCCAATTAGCA
AGAATTGGCTCTCATAGCGATTTGTTCTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10053.51 Da
• Isoelectric Point: 6.0643

>AT95067 WP_032480862.1 NZ_CP026532:656311-656589 [Vibrio cholerae]
MRTEMLSTRIDHDTKVAFTSICDEMGLSTSQAIKIFAKAVINHGGIPFDLRVPQPNETTISAMNELVQGHGHKAESVDAM
LTELTEGKVKNV

Nucleotide

• Length: 279 bp

>AT95067 NZ_CP026532:656311-656589 [Vibrio cholerae]
ATGAGAACAGAAATGCTAAGTACTCGCATAGACCATGATACCAAAGTTGCTTTTACTAGCATTTGTGACGAAATGGGTCT
TAGTACATCACAAGCTATTAAAATTTTTGCAAAAGCCGTGATTAATCATGGTGGTATTCCATTTGACTTACGTGTGCCTC
AACCAAATGAAACAACGATTTCTGCAATGAATGAACTCGTTCAAGGTCATGGGCATAAAGCAGAATCTGTCGACGCTATG
CTTACTGAGTTAACTGAAGGCAAAGTTAAGAATGTATAG

Structures

Antitoxin

• AlphaFold DB: A0A1T4SKS5