Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-YefM |
| Location | 619131..619709 | Replicon | chromosome |
| Accession | NZ_CP026532 | ||
| Organism | Vibrio cholerae strain FORC_076 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | FORC76_RS16745 | Protein ID | WP_002033256.1 |
| Coordinates | 619392..619709 (+) | Length | 106 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | - |
| Locus tag | FORC76_RS16740 | Protein ID | WP_000557287.1 |
| Coordinates | 619131..619373 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FORC76_RS16680 | 614367..614864 | - | 498 | WP_000259904.1 | GNAT family N-acetyltransferase | - |
| FORC76_RS19290 | 615068..615163 | - | 96 | WP_001907607.1 | DUF645 family protein | - |
| FORC76_RS16705 | 615511..616398 | - | 888 | WP_181716833.1 | DUF4263 domain-containing protein | - |
| FORC76_RS16710 | 616745..616981 | - | 237 | WP_164971224.1 | DUF3709 domain-containing protein | - |
| FORC76_RS16720 | 617251..617634 | - | 384 | WP_001081300.1 | hypothetical protein | - |
| FORC76_RS16725 | 617793..618149 | - | 357 | WP_002033264.1 | hypothetical protein | - |
| FORC76_RS16730 | 618380..618622 | + | 243 | WP_001107719.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| FORC76_RS16735 | 618619..618918 | + | 300 | WP_000802136.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| FORC76_RS16740 | 619131..619373 | + | 243 | WP_000557287.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| FORC76_RS16745 | 619392..619709 | + | 318 | WP_002033256.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FORC76_RS16755 | 619856..620533 | - | 678 | WP_002033254.1 | FMN-binding negative transcriptional regulator | - |
| FORC76_RS16760 | 620684..620929 | + | 246 | WP_001260801.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| FORC76_RS16765 | 620929..621246 | + | 318 | WP_032480890.1 | CcdB family protein | - |
| FORC76_RS16775 | 621363..621827 | - | 465 | WP_002033245.1 | GNAT family N-acetyltransferase | - |
| FORC76_RS16780 | 621971..622474 | - | 504 | WP_113612945.1 | DinB family protein | - |
| FORC76_RS16790 | 622532..622651 | - | 120 | WP_080285011.1 | DUF3265 domain-containing protein | - |
| FORC76_RS16800 | 624027..624248 | - | 222 | WP_032469388.1 | DUF3709 domain-containing protein | - |
| FORC76_RS16805 | 624269..624430 | - | 162 | WP_113625331.1 | DUF3709 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | blaCARB-9 | - | 564019..691460 | 127441 | |
| - | inside | Integron | - | - | 566037..688204 | 122167 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12158.93 Da Isoelectric Point: 9.5552
>T95066 WP_002033256.1 NZ_CP026532:619392-619709 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLQQSRFVS
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLQQSRFVS
Download Length: 318 bp
>T95066 NZ_CP026532:619392-619709 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTAGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTTGGAAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATCGTCGCAGTATTAGGGCAATCACAACTACCCCAAAAACATCTCCAACAGTCACGCTTTGTTTCTTAG
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTAGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTTGGAAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATCGTCGCAGTATTAGGGCAATCACAACTACCCCAAAAACATCTCCAACAGTCACGCTTTGTTTCTTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 8982.23 Da Isoelectric Point: 5.0616
>AT95066 WP_000557287.1 NZ_CP026532:619131-619373 [Vibrio cholerae]
MHTLTANDAKRHFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDNGETVDGAAFLNTL
MHTLTANDAKRHFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDNGETVDGAAFLNTL
Download Length: 243 bp
>AT95066 NZ_CP026532:619131-619373 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGACATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGATTTTGAAGAACTTGAAGCCATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAATGGTGAAACCGTTGATGGTGCAGCTTTTCTAAACACCCTT
TGA
ATGCACACACTAACAGCAAATGATGCTAAACGACATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGATTTTGAAGAACTTGAAGCCATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAATGGTGAAACCGTTGATGGTGCAGCTTTTCTAAACACCCTT
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|