Detailed information of TA system TA095064

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 611302..611867
• Replicon: chromosome
• Accession: NZ_CP026532
• Organism: Vibrio cholerae strain FORC_076

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FORC76_RS16645
• Protein ID: WP_000869994.1
• Coordinates: 611302..611589 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: W9USL4
• Locus tag: FORC76_RS16650
• Protein ID: WP_000086650.1
• Coordinates: 611586..611867 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC76_RS16600	606772..608124	-	1353	WP_032480853.1	trypsin-like serine protease	-
FORC76_RS16605	608294..608653	-	360	WP_001071528.1	VOC family protein	-
FORC76_RS16610	608940..609218	-	279	WP_032482690.1	DUF3709 domain-containing protein	-
FORC76_RS16615	609466..609879	-	414	WP_032480885.1	GNAT family N-acetyltransferase	-
FORC76_RS16620	610187..610408	-	222	WP_002029826.1	DUF3709 domain-containing protein	-
FORC76_RS16625	610405..610623	-	219	WP_002029824.1	DUF3709 domain-containing protein	-
FORC76_RS16635	610692..611144	-	453	WP_000394005.1	hypothetical protein	-
FORC76_RS16640	611182..611292	-	111	WP_080115538.1	DUF3265 domain-containing protein	-
FORC76_RS16645	611302..611589	-	288	WP_000869994.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FORC76_RS16650	611586..611867	-	282	WP_000086650.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FORC76_RS16655	612121..612546	-	426	WP_000415755.1	hypothetical protein	-
FORC76_RS16660	612863..613044	-	182	Protein_550	DUF645 family protein	-
FORC76_RS16665	613365..613655	-	291	WP_080006757.1	YkgJ family cysteine cluster protein	-
FORC76_RS16670	613922..614074	-	153	Protein_552	DUF645 family protein	-
FORC76_RS16680	614367..614864	-	498	WP_000259904.1	GNAT family N-acetyltransferase	-
FORC76_RS19290	615068..615163	-	96	WP_001907607.1	DUF645 family protein	-
FORC76_RS16705	615511..616398	-	888	WP_181716833.1	DUF4263 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	blaCARB-9	-	564019..691460	127441
	-	inside	Integron	-	-	566037..688204	122167

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10895.69 Da
• Isoelectric Point: 5.6023

>T95064 WP_000869994.1 NZ_CP026532:c611589-611302 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNDVLDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLGLEIRV
LTVRNCRQLLTEHDV

Nucleotide

• Length: 288 bp

>T95064 NZ_CP026532:c611589-611302 [Vibrio cholerae]
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCCGCAGAGTTTATTGCTTTGGATAACCCCTCAGC
TGCAGAAAAGTGGGTGAATGATGTGCTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACAAACTACCGTGAAATAATTTTTGGTCATTACCGCATTATTTATAGTTTGGGTCTCGAAATACGAGTT
CTAACAGTCCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10347.90 Da
• Isoelectric Point: 5.1548

>AT95064 WP_000086650.1 NZ_CP026532:c611867-611586 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGVSN
EDARSQVLGRIIK

Nucleotide

• Length: 282 bp

>AT95064 NZ_CP026532:c611867-611586 [Vibrio cholerae]
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTATCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAAACTCGTCGGCCATTAGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTTGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTGGGTGTATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGACGCATCATCAAATGA

Structures

Antitoxin

• AlphaFold DB: W9USL4