Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /GNAT-DUF1778 |
| Location | 596514..597280 | Replicon | chromosome |
| Accession | NZ_CP026532 | ||
| Organism | Vibrio cholerae strain FORC_076 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | Q9K2P7 |
| Locus tag | FORC76_RS16520 | Protein ID | WP_000982260.1 |
| Coordinates | 596783..597280 (+) | Length | 166 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | FORC76_RS16515 | Protein ID | WP_001915058.1 |
| Coordinates | 596514..596786 (+) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FORC76_RS19200 | 591681..592592 | - | 912 | WP_032480859.1 | hypothetical protein | - |
| FORC76_RS16465 | 592926..593123 | - | 198 | WP_080006741.1 | DUF3709 domain-containing protein | - |
| FORC76_RS16470 | 593117..593278 | - | 162 | Protein_518 | hypothetical protein | - |
| FORC76_RS16475 | 593367..593885 | - | 519 | WP_000699012.1 | GNAT family N-acetyltransferase | - |
| FORC76_RS16480 | 594052..594603 | - | 552 | WP_000821929.1 | hypothetical protein | - |
| FORC76_RS16485 | 594777..595211 | - | 435 | WP_000256034.1 | GNAT family N-acetyltransferase | - |
| FORC76_RS16490 | 595408..595446 | - | 39 | WP_113594548.1 | hypothetical protein | - |
| FORC76_RS16495 | 595462..595590 | - | 129 | Protein_523 | DUF645 family protein | - |
| FORC76_RS16505 | 595943..596124 | - | 182 | Protein_524 | DUF645 family protein | - |
| FORC76_RS16515 | 596514..596786 | + | 273 | WP_001915058.1 | DUF1778 domain-containing protein | Antitoxin |
| FORC76_RS16520 | 596783..597280 | + | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | Toxin |
| FORC76_RS16525 | 597469..597648 | + | 180 | WP_160171678.1 | BLUF domain-containing protein | - |
| FORC76_RS16530 | 597584..597916 | + | 333 | WP_158087294.1 | BLUF domain-containing protein | - |
| FORC76_RS16535 | 598034..599857 | - | 1824 | WP_002033289.1 | hypothetical protein | - |
| FORC76_RS16540 | 600054..600233 | - | 180 | WP_032480874.1 | DUF645 family protein | - |
| FORC76_RS16545 | 600547..601170 | - | 624 | WP_000247072.1 | DUF1349 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | blaCARB-9 | - | 564019..691460 | 127441 | |
| - | inside | Integron | - | - | 566037..688204 | 122167 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 166 a.a. Molecular weight: 18527.18 Da Isoelectric Point: 8.7753
>T95063 WP_000982260.1 NZ_CP026532:596783-597280 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG
Download Length: 498 bp
>T95063 NZ_CP026532:596783-597280 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCCCTCAACAATTA
CTTAAAAGTAATGGCAAGTCAGCAAGCCAAAAAAGACAACACGAGAACCTTCGTTTTGGAAGATGACAATAATAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACACCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCTTCAACCTCTGGAGGACTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCGCTCAGAAAGCTACTCGCAGCCAGTGACAGCGTAGCGTTCCCTGTTGTCATCGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCTTTTCAAGATGCCGAAAACAAACTCTTCATCACTATTGCTGATATC
AGAGCAAGCTTAGGCTAG
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCCCTCAACAATTA
CTTAAAAGTAATGGCAAGTCAGCAAGCCAAAAAAGACAACACGAGAACCTTCGTTTTGGAAGATGACAATAATAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACACCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCTTCAACCTCTGGAGGACTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCGCTCAGAAAGCTACTCGCAGCCAGTGACAGCGTAGCGTTCCCTGTTGTCATCGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCTTTTCAAGATGCCGAAAACAAACTCTTCATCACTATTGCTGATATC
AGAGCAAGCTTAGGCTAG
Antitoxin
Download Length: 91 a.a. Molecular weight: 9655.16 Da Isoelectric Point: 6.2988
>AT95063 WP_001915058.1 NZ_CP026532:596514-596786 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVANAKLKL
ASERYESKTQ
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVANAKLKL
ASERYESKTQ
Download Length: 273 bp
>AT95063 NZ_CP026532:596514-596786 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGCATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCGGTAGCAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGCATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCGGTAGCAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|