95061

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 582840..583368 Replicon chromosome
Accession NZ_CP026532
Organism Vibrio cholerae strain FORC_076

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag FORC76_RS16360 Protein ID WP_000221352.1
Coordinates 583078..583368 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag FORC76_RS16355 Protein ID WP_000213183.1
Coordinates 582840..583088 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC76_RS16310 578715..579428 - 714 WP_181712206.1 Fic family protein -
FORC76_RS16315 579512..579622 - 111 WP_113625348.1 DUF3265 domain-containing protein -
FORC76_RS16320 579632..579919 - 288 WP_084988710.1 type II toxin-antitoxin system RelE/ParE family toxin -
FORC76_RS16325 579916..580197 - 282 WP_000086650.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FORC76_RS16335 580411..580800 - 390 WP_000491259.1 VOC family protein -
FORC76_RS16340 581136..581396 - 261 WP_161419140.1 DUF3709 domain-containing protein -
FORC76_RS16345 581725..582177 + 453 WP_000024294.1 DUF2384 domain-containing protein -
FORC76_RS16350 582177..582647 + 471 WP_000784956.1 RES family NAD+ phosphorylase -
FORC76_RS16355 582840..583088 + 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FORC76_RS16360 583078..583368 + 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORC76_RS16365 583556..583737 - 182 Protein_500 DUF645 family protein -
FORC76_RS16370 583907..583975 - 69 Protein_501 glutathione S-transferase family protein -
FORC76_RS16375 584041..584436 - 396 WP_001923862.1 DUF3465 domain-containing protein -
FORC76_RS16380 584724..584957 - 234 WP_001990688.1 DUF3709 domain-containing protein -
FORC76_RS16385 584978..585139 - 162 WP_113625331.1 DUF3709 domain-containing protein -
FORC76_RS16390 585230..585766 - 537 WP_084988691.1 GNAT family N-acetyltransferase -
FORC76_RS16395 585915..586417 - 503 Protein_506 DinB family protein -
FORC76_RS16405 586645..586826 - 182 Protein_507 DUF645 family protein -
FORC76_RS16410 587252..587575 - 324 WP_080006739.1 DUF3709 domain-containing protein -
FORC76_RS16415 587762..588268 - 507 WP_000403020.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island blaCARB-9 - 564019..691460 127441
- inside Integron - - 566037..688204 122167


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T95061 WP_000221352.1 NZ_CP026532:583078-583368 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T95061 NZ_CP026532:583078-583368 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTTTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT95061 WP_000213183.1 NZ_CP026532:582840-583088 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT95061 NZ_CP026532:582840-583088 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGCGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCTAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References