Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafN(antitoxin) |
| Location | 579632..580197 | Replicon | chromosome |
| Accession | NZ_CP026532 | ||
| Organism | Vibrio cholerae strain FORC_076 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | FORC76_RS16320 | Protein ID | WP_084988710.1 |
| Coordinates | 579632..579919 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | W9USL4 |
| Locus tag | FORC76_RS16325 | Protein ID | WP_000086650.1 |
| Coordinates | 579916..580197 (-) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FORC76_RS16280 | 574855..576090 | - | 1236 | WP_000461057.1 | hypothetical protein | - |
| FORC76_RS16285 | 577076..577324 | - | 249 | Protein_486 | DUF3709 domain-containing protein | - |
| FORC76_RS16290 | 577318..577449 | - | 132 | WP_119565136.1 | DUF3709 domain-containing protein | - |
| FORC76_RS16295 | 577459..577569 | - | 111 | WP_080006748.1 | DUF3265 domain-containing protein | - |
| FORC76_RS16300 | 577566..578153 | - | 588 | WP_000466202.1 | NAD(P)H-dependent oxidoreductase | - |
| FORC76_RS16310 | 578715..579428 | - | 714 | WP_181712206.1 | Fic family protein | - |
| FORC76_RS16315 | 579512..579622 | - | 111 | WP_113625348.1 | DUF3265 domain-containing protein | - |
| FORC76_RS16320 | 579632..579919 | - | 288 | WP_084988710.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FORC76_RS16325 | 579916..580197 | - | 282 | WP_000086650.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| FORC76_RS16335 | 580411..580800 | - | 390 | WP_000491259.1 | VOC family protein | - |
| FORC76_RS16340 | 581136..581396 | - | 261 | WP_161419140.1 | DUF3709 domain-containing protein | - |
| FORC76_RS16345 | 581725..582177 | + | 453 | WP_000024294.1 | DUF2384 domain-containing protein | - |
| FORC76_RS16350 | 582177..582647 | + | 471 | WP_000784956.1 | RES family NAD+ phosphorylase | - |
| FORC76_RS16355 | 582840..583088 | + | 249 | WP_000213183.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| FORC76_RS16360 | 583078..583368 | + | 291 | WP_000221352.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| FORC76_RS16365 | 583556..583737 | - | 182 | Protein_500 | DUF645 family protein | - |
| FORC76_RS16370 | 583907..583975 | - | 69 | Protein_501 | glutathione S-transferase family protein | - |
| FORC76_RS16375 | 584041..584436 | - | 396 | WP_001923862.1 | DUF3465 domain-containing protein | - |
| FORC76_RS16380 | 584724..584957 | - | 234 | WP_001990688.1 | DUF3709 domain-containing protein | - |
| FORC76_RS16385 | 584978..585139 | - | 162 | WP_113625331.1 | DUF3709 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | blaCARB-9 | - | 564019..691460 | 127441 | |
| - | inside | Integron | - | - | 566037..688204 | 122167 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10957.76 Da Isoelectric Point: 5.6023
>T95060 WP_084988710.1 NZ_CP026532:c579919-579632 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIALDNPSVAEKWVNDVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLGLEIRV
LTVRNCRQLLTEHDV
MKVVWSPLALQKLGDAAEFIALDNPSVAEKWVNDVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLGLEIRV
LTVRNCRQLLTEHDV
Download Length: 288 bp
>T95060 NZ_CP026532:c579919-579632 [Vibrio cholerae]
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCTGCAGAGTTTATTGCTTTGGATAACCCCTCAGT
TGCAGAAAAGTGGGTGAATGATGTGTTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACAAACTACCGTGAAATAATTTTTGGTCATTACCGCATTATTTATAGTTTGGGTCTCGAAATACGAGTT
CTAACAGTCCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCTGCAGAGTTTATTGCTTTGGATAACCCCTCAGT
TGCAGAAAAGTGGGTGAATGATGTGTTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACAAACTACCGTGAAATAATTTTTGGTCATTACCGCATTATTTATAGTTTGGGTCTCGAAATACGAGTT
CTAACAGTCCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10347.90 Da Isoelectric Point: 5.1548
>AT95060 WP_000086650.1 NZ_CP026532:c580197-579916 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGVSN
EDARSQVLGRIIK
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGVSN
EDARSQVLGRIIK
Download Length: 282 bp
>AT95060 NZ_CP026532:c580197-579916 [Vibrio cholerae]
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTATCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAAACTCGTCGGCCATTAGTTATTACTCAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTTGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTGGGTGTATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGACGCATCATCAAATGA
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTATCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAAACTCGTCGGCCATTAGTTATTACTCAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTTGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTGGGTGTATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGACGCATCATCAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|