Detailed information of TA system TA095059

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /DUF1778(antitoxin)
• Location: 567663..568594
• Replicon: chromosome
• Accession: NZ_CP026532
• Organism: Vibrio cholerae strain FORC_076

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FORC76_RS16220
• Protein ID: WP_032482373.1
• Coordinates: 567663..568196 (-)
• Length: 178 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FORC76_RS16225
• Protein ID: WP_164971228.1
• Coordinates: 568193..568594 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC76_RS16185	564560..565546	+	987	WP_001170905.1	sulfate ABC transporter substrate-binding protein	-
FORC76_RS16195	565747..566049	-	303	WP_000229322.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FORC76_RS16200	566037..566294	-	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
FORC76_RS16205	566546..566727	-	182	Protein_473	DUF645 family protein	-
FORC76_RS16210	567022..567516	-	495	WP_000573470.1	GNAT family N-acetyltransferase	-
FORC76_RS16220	567663..568196	-	534	WP_032482373.1	GNAT family N-acetyltransferase	Toxin
FORC76_RS16225	568193..568594	-	402	WP_164971228.1	DUF1778 domain-containing protein	Antitoxin
FORC76_RS16235	568699..569238	-	540	WP_000884553.1	isochorismatase family protein	-
FORC76_RS16240	569393..570259	-	867	WP_002153223.1	PSE family carbenicillin-hydrolyzing class A beta-lactamase	-
FORC76_RS16245	570446..571450	-	1005	WP_000964926.1	LD-carboxypeptidase	-
FORC76_RS16250	571662..571843	-	182	Protein_480	DUF645 family protein	-
FORC76_RS16260	572138..572917	-	780	Protein_481	DUF3800 domain-containing protein	-
FORC76_RS16265	573129..573310	-	182	Protein_482	DUF645 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	blaCARB-9	-	564019..691460	127441
	-	inside	Integron	-	-	566037..688204	122167

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (96-160)

Antitoxin

• Vibrio phage ICP1, Orf50 (49-125)

Sequences

Toxin

Protein

• Length: 178 a.a.
• Molecular weight: 20151.47 Da
• Isoelectric Point: 9.1432

>T95059 WP_032482373.1 NZ_CP026532:c568196-567663 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPIFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQALYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Nucleotide

• Length: 534 bp

>T95059 NZ_CP026532:c568196-567663 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGAGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTATTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGCTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14895.28 Da
• Isoelectric Point: 7.7706

>AT95059 WP_164971228.1 NZ_CP026532:c568594-568193 [Vibrio cholerae]
MRCQHLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVR
LMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Nucleotide

• Length: 402 bp

>AT95059 NZ_CP026532:c568594-568193 [Vibrio cholerae]
ATGCGTTGCCAGCACCTTAGGCGGGCGTTATATTCTCCCTCGCCCCGTAAACTTTCCGTACGAATTGAATGTGCTTTAAG
TTTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGGCAACGGCACGTTTAGATATCCGCC
TTGATGAAGAGATCAAGGCAAAAGCCGAAAAGGCATCGGCTTTACTTGGTTTAAAAAGTCTCACTGAATATGTGGTGAGA
CTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAAAGACAGTGTTTTTGACGAGTTTAT
GGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAATTTACAGAGAAGAGCGGTATCAAGT
GA