Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 567663..568594 Replicon chromosome
Accession NZ_CP026532
Organism Vibrio cholerae strain FORC_076

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag FORC76_RS16220 Protein ID WP_032482373.1
Coordinates 567663..568196 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag FORC76_RS16225 Protein ID WP_164971228.1
Coordinates 568193..568594 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC76_RS16185 564560..565546 + 987 WP_001170905.1 sulfate ABC transporter substrate-binding protein -
FORC76_RS16195 565747..566049 - 303 WP_000229322.1 type II toxin-antitoxin system RelE/ParE family toxin -
FORC76_RS16200 566037..566294 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FORC76_RS16205 566546..566727 - 182 Protein_473 DUF645 family protein -
FORC76_RS16210 567022..567516 - 495 WP_000573470.1 GNAT family N-acetyltransferase -
FORC76_RS16220 567663..568196 - 534 WP_032482373.1 GNAT family N-acetyltransferase Toxin
FORC76_RS16225 568193..568594 - 402 WP_164971228.1 DUF1778 domain-containing protein Antitoxin
FORC76_RS16235 568699..569238 - 540 WP_000884553.1 isochorismatase family protein -
FORC76_RS16240 569393..570259 - 867 WP_002153223.1 PSE family carbenicillin-hydrolyzing class A beta-lactamase -
FORC76_RS16245 570446..571450 - 1005 WP_000964926.1 LD-carboxypeptidase -
FORC76_RS16250 571662..571843 - 182 Protein_480 DUF645 family protein -
FORC76_RS16260 572138..572917 - 780 Protein_481 DUF3800 domain-containing protein -
FORC76_RS16265 573129..573310 - 182 Protein_482 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island blaCARB-9 - 564019..691460 127441
- inside Integron - - 566037..688204 122167


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(96-160)

Antitoxin

Vibrio phage ICP1, Orf50

(49-125)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20151.47 Da        Isoelectric Point: 9.1432

>T95059 WP_032482373.1 NZ_CP026532:c568196-567663 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPIFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQALYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T95059 NZ_CP026532:c568196-567663 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGAGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTATTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGCTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14895.28 Da        Isoelectric Point: 7.7706

>AT95059 WP_164971228.1 NZ_CP026532:c568594-568193 [Vibrio cholerae]
MRCQHLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVR
LMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 402 bp

>AT95059 NZ_CP026532:c568594-568193 [Vibrio cholerae]
ATGCGTTGCCAGCACCTTAGGCGGGCGTTATATTCTCCCTCGCCCCGTAAACTTTCCGTACGAATTGAATGTGCTTTAAG
TTTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGGCAACGGCACGTTTAGATATCCGCC
TTGATGAAGAGATCAAGGCAAAAGCCGAAAAGGCATCGGCTTTACTTGGTTTAAAAAGTCTCACTGAATATGTGGTGAGA
CTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAAAGACAGTGTTTTTGACGAGTTTAT
GGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAATTTACAGAGAAGAGCGGTATCAAGT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References