95058

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 565747..566294 Replicon chromosome
Accession NZ_CP026532
Organism Vibrio cholerae strain FORC_076

Toxin (Protein)


Gene name relE Uniprot ID A0A0Q0PYS1
Locus tag FORC76_RS16195 Protein ID WP_000229322.1
Coordinates 565747..566049 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag FORC76_RS16200 Protein ID WP_000861987.1
Coordinates 566037..566294 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC76_RS19195 562270..562446 + 177 WP_001924080.1 hypothetical protein -
FORC76_RS16180 562462..563549 - 1088 Protein_469 hypothetical protein -
FORC76_RS16185 564560..565546 + 987 WP_001170905.1 sulfate ABC transporter substrate-binding protein -
FORC76_RS16195 565747..566049 - 303 WP_000229322.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORC76_RS16200 566037..566294 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FORC76_RS16205 566546..566727 - 182 Protein_473 DUF645 family protein -
FORC76_RS16210 567022..567516 - 495 WP_000573470.1 GNAT family N-acetyltransferase -
FORC76_RS16220 567663..568196 - 534 WP_032482373.1 GNAT family N-acetyltransferase -
FORC76_RS16225 568193..568594 - 402 WP_164971228.1 DUF1778 domain-containing protein -
FORC76_RS16235 568699..569238 - 540 WP_000884553.1 isochorismatase family protein -
FORC76_RS16240 569393..570259 - 867 WP_002153223.1 PSE family carbenicillin-hydrolyzing class A beta-lactamase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island blaCARB-9 - 564019..691460 127441
- inside Integron - - 566037..688204 122167


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11737.67 Da        Isoelectric Point: 5.1972

>T95058 WP_000229322.1 NZ_CP026532:c566049-565747 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T95058 NZ_CP026532:c566049-565747 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCCTGCTCTATCCGACCTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGACGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAATCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT95058 WP_000861987.1 NZ_CP026532:c566294-566037 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT95058 NZ_CP026532:c566294-566037 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGGCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAGCCGTCAGCTTACCTTATTGATGTAGACGATTATGAATTTATGCAAAATCGTTTAGCGA
TCCTCGAAGGCATTGCTCGTGGCGAGCGAGCTCTAGCGGATGGCAAAGTGGTTAGCCACCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PYS1

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References