Detailed information of TA system TA095052

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1295172..1295671
• Replicon: plasmid pSymA
• Accession: NZ_CP026526
• Organism: Sinorhizobium meliloti strain AK21

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q92YA6
• Locus tag: C3L21_RS25165
• Protein ID: WP_010967939.1
• Coordinates: 1295172..1295345 (-)
• Length: 58 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: C3L21_RS36185
• Protein ID: WP_017272263.1
• Coordinates: 1295342..1295671 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C3L21_RS25135	1291047..1292363	+	1317	WP_014531394.1	aspartate aminotransferase family protein	-
C3L21_RS25140	1292733..1293218	-	486	WP_014531392.1	YidB family protein	-
C3L21_RS25145	1293246..1293497	-	252	WP_003534243.1	GlsB/YeaQ/YmgE family stress response membrane protein	-
C3L21_RS25150	1294092..1294451	+	360	WP_013845635.1	glyoxalase/bleomycin resistance/dioxygenase family protein	-
C3L21_RS25155	1294444..1294683	+	240	WP_017272264.1	hypothetical protein	-
C3L21_RS25160	1294769..1295074	+	306	WP_013845638.1	hypothetical protein	-
C3L21_RS25165	1295172..1295345	-	174	WP_010967939.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C3L21_RS36185	1295342..1295671	-	330	WP_017272263.1	hypothetical protein	Antitoxin
C3L21_RS25175	1296032..1297402	+	1371	WP_017265792.1	alpha/beta hydrolase	-
C3L21_RS25180	1297786..1298127	+	342	Protein_1251	hypothetical protein	-
C3L21_RS25185	1298111..1298449	-	339	WP_013845641.1	SDR family oxidoreductase	-
C3L21_RS25190	1298558..1299001	-	444	WP_010967942.1	PACE efflux transporter	-
C3L21_RS25195	1299093..1299827	+	735	Protein_1254	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	htpB / htpB	1..1506823	1506823

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 58 a.a.
• Molecular weight: 6497.32 Da
• Isoelectric Point: 5.7733

>T95052 WP_010967939.1 NZ_CP026526:c1295345-1295172 [Sinorhizobium meliloti]
MKLVWARYALDDRDAIFSYIERENPRAAVHVDEEVVSAGRPLDFPESRRPGRIAGTP

Nucleotide

• Length: 174 bp

>T95052 NZ_CP026526:c1295345-1295172 [Sinorhizobium meliloti]
ATGAAGCTCGTCTGGGCGCGATATGCGCTTGACGATCGCGACGCCATCTTCAGCTACATCGAACGAGAGAATCCGAGGGC
GGCGGTCCACGTTGACGAGGAGGTCGTCAGCGCTGGTCGTCCGCTGGACTTTCCCGAAAGCCGCCGCCCTGGCCGGATTG
CCGGAACTCCATGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12025.64 Da
• Isoelectric Point: 11.1401

>AT95052 WP_017272263.1 NZ_CP026526:c1295671-1295342 [Sinorhizobium meliloti]
VSERLLLIALLALGPFRASQRHTGRPALLRRGPQSAAGAVEEHFIQLRAPLWLITLGGFSHREAHDAWFRAKALRALEDT
RPDADDADADAHFQERRAAALRKAAAGDR

Nucleotide

• Length: 330 bp

>AT95052 NZ_CP026526:c1295671-1295342 [Sinorhizobium meliloti]
GTGAGCGAGCGCCTTCTGCTCATCGCCCTCCTGGCCCTCGGTCCGTTCCGAGCCAGCCAGCGGCATACCGGTCGTCCTGC
TCTGCTACGGCGTGGCCCCCAATCGGCCGCCGGCGCGGTCGAGGAGCACTTCATCCAACTCCGCGCTCCGCTGTGGCTGA
TCACGCTCGGCGGTTTCAGCCACAGAGAGGCTCACGACGCTTGGTTCCGCGCCAAAGCTTTGCGGGCACTCGAGGACACT
CGACCCGATGCGGACGACGCCGACGCCGATGCGCACTTTCAAGAGCGCCGCGCCGCAGCTTTGCGCAAGGCTGCGGCGGG
TGATCGATGA

Structures

Toxin

• AlphaFold DB: Q92YA6