95049

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3747778..3748439 Replicon chromosome
Accession NZ_CP026525
Organism Sinorhizobium meliloti strain AK21

Toxin (Protein)


Gene name vapC Uniprot ID H0G400
Locus tag C3L21_RS18385 Protein ID WP_003531794.1
Coordinates 3747778..3748182 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID H0G3Z9
Locus tag C3L21_RS18390 Protein ID WP_003531793.1
Coordinates 3748179..3748439 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3L21_RS18370 3743374..3744486 + 1113 WP_003535893.1 3-isopropylmalate dehydrogenase -
C3L21_RS18375 3744615..3745322 + 708 WP_127521406.1 phosphatase PAP2 family protein -
C3L21_RS18380 3745423..3747312 - 1890 WP_003535895.1 MHS family MFS transporter -
C3L21_RS18385 3747778..3748182 - 405 WP_003531794.1 type II toxin-antitoxin system VapC family toxin Toxin
C3L21_RS18390 3748179..3748439 - 261 WP_003531793.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
C3L21_RS18400 3748852..3749886 + 1035 WP_003531790.1 aspartate-semialdehyde dehydrogenase -
C3L21_RS18405 3750059..3750880 + 822 WP_003531785.1 lytic transglycosylase family protein -
C3L21_RS18410 3751227..3751910 - 684 WP_010970569.1 carbonic anhydrase -
C3L21_RS18415 3752084..3752965 - 882 WP_015008003.1 pyridoxal kinase PdxY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(8-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14480.69 Da        Isoelectric Point: 6.7257

>T95049 WP_003531794.1 NZ_CP026525:c3748182-3747778 [Sinorhizobium meliloti]
VISHILDTSAVIALIGRKSDALVTRVLHSPQGIIGLPSVVAYELYFGAQKSAKAQHNLETLRLLMADFPILDFDRNDAFV
AGEIRAALAAKGTPIGPYDVLIAGQAKARGLTLVTNNVGEFNRVENLRVEDWSL

Download         Length: 405 bp

>T95049 NZ_CP026525:c3748182-3747778 [Sinorhizobium meliloti]
GTGATCTCCCATATTCTCGACACCAGCGCCGTCATCGCTTTGATCGGGCGCAAATCGGATGCATTGGTCACCCGTGTACT
CCATAGCCCTCAGGGCATTATCGGGCTCCCGTCGGTCGTCGCGTATGAACTCTATTTTGGAGCGCAGAAAAGCGCGAAGG
CCCAACACAATCTCGAAACCCTGCGTTTGTTGATGGCGGATTTTCCGATCCTCGACTTCGACCGGAACGATGCCTTTGTC
GCAGGCGAGATCCGGGCCGCCCTTGCCGCGAAGGGTACGCCCATCGGACCTTATGACGTGCTGATTGCGGGACAGGCCAA
AGCCCGTGGATTGACGCTCGTCACCAACAATGTCGGCGAGTTCAATAGGGTTGAGAACCTGCGCGTGGAGGATTGGTCGC
TCTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9913.20 Da        Isoelectric Point: 5.1253

>AT95049 WP_003531793.1 NZ_CP026525:c3748439-3748179 [Sinorhizobium meliloti]
MPHLARVFQSGNSQAVRLPKEFRFNVDRVEITQEGDALILRPHVEQGEQWSSLKAALARGMSEDFMMCGREQPEQQDRPE
LDAVFR

Download         Length: 261 bp

>AT95049 NZ_CP026525:c3748439-3748179 [Sinorhizobium meliloti]
ATGCCCCATCTTGCACGGGTGTTCCAGTCCGGAAATTCGCAGGCCGTCCGCCTGCCTAAGGAATTCCGCTTCAACGTCGA
TCGCGTCGAAATCACGCAGGAAGGCGACGCGCTCATTCTCCGCCCGCACGTCGAGCAAGGCGAGCAGTGGTCATCGCTGA
AGGCGGCACTTGCCCGTGGCATGAGTGAAGACTTCATGATGTGCGGGCGCGAGCAGCCGGAACAGCAGGATCGGCCGGAA
CTCGACGCGGTATTTCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H0G400

Antitoxin

Source ID Structure
AlphaFold DB H0G3Z9

References