Detailed information of TA system TA095046

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 2383153..2383807
• Replicon: chromosome
• Accession: NZ_CP026525
• Organism: Sinorhizobium meliloti strain AK21

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: H0G1A3
• Locus tag: C3L21_RS11820
• Protein ID: WP_003530010.1
• Coordinates: 2383153..2383341 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q92NX0
• Locus tag: C3L21_RS11825
• Protein ID: WP_010969659.1
• Coordinates: 2383346..2383807 (+)
• Length: 154 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C3L21_RS11805	2379719..2381029	+	1311	WP_158528571.1	HlyD family type I secretion periplasmic adaptor subunit	-
C3L21_RS11810	2381054..2382025	-	972	WP_017265202.1	glycosyltransferase family 2 protein	-
C3L21_RS11815	2382206..2382976	-	771	WP_010969658.1	hypothetical protein	-
C3L21_RS11820	2383153..2383341	+	189	WP_003530010.1	type II toxin-antitoxin system HicA family toxin	Toxin
C3L21_RS11825	2383346..2383807	+	462	WP_010969659.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
C3L21_RS11830	2384355..2384588	-	234	WP_086019424.1	hypothetical protein	-
C3L21_RS11835	2384501..2384914	-	414	WP_086019425.1	hypothetical protein	-
C3L21_RS11840	2384866..2385252	-	387	WP_026030921.1	hypothetical protein	-
C3L21_RS35965	2385423..2385593	+	171	WP_017266548.1	hypothetical protein	-
C3L21_RS11845	2386098..2386271	-	174	WP_017266546.1	DUF3606 domain-containing protein	-
C3L21_RS11850	2387091..2387294	-	204	WP_026029857.1	hypothetical protein	-
C3L21_RS11855	2387939..2388304	-	366	WP_158528572.1	hypothetical protein	-
C3L21_RS11865	2388508..2388792	-	285	WP_026030459.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2360145..2436823	76678

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 6971.15 Da
• Isoelectric Point: 11.0889

>T95046 WP_003530010.1 NZ_CP026525:2383153-2383341 [Sinorhizobium meliloti]
MKSGDIIAALQKDGWYEVATKGSHVQFKHPKKHGRVTVPHPKRDLPIGTLRSIEKQSGLKLR

Nucleotide

• Length: 189 bp

>T95046 NZ_CP026525:2383153-2383341 [Sinorhizobium meliloti]
ATGAAGAGCGGCGACATTATTGCAGCATTGCAGAAGGACGGATGGTACGAGGTTGCGACCAAGGGCAGCCACGTTCAATT
CAAACATCCGAAAAAGCACGGCCGGGTTACCGTTCCTCACCCGAAGAGGGATCTACCAATCGGTACCCTCAGGAGCATTG
AAAAGCAGTCCGGTTTGAAATTGAGGTAA

Antitoxin

Protein

• Length: 154 a.a.
• Molecular weight: 16293.17 Da
• Isoelectric Point: 4.3990

>AT95046 WP_010969659.1 NZ_CP026525:2383346-2383807 [Sinorhizobium meliloti]
MRNYIGLIHKDAESDYGVSFPDFSGVVTAGADLDDARAMAEEALALHIEGLVEDGEAIPEPSSLEVVMSDAENRDCVAIL
VAVKTEAKRAIRVNVTLPEGVLKQIDAFAEAHGLTRSGFLARAATHEIERANDGHDAYAESRLSALGTSSKNV

Nucleotide

• Length: 462 bp

>AT95046 NZ_CP026525:2383346-2383807 [Sinorhizobium meliloti]
ATGCGCAACTATATCGGATTGATCCACAAGGACGCCGAGAGCGATTACGGCGTTTCCTTTCCTGATTTTTCCGGCGTCGT
GACCGCCGGTGCCGACCTCGACGACGCGCGCGCTATGGCAGAGGAAGCCTTGGCCTTGCATATTGAAGGGCTGGTAGAGG
ACGGCGAGGCCATCCCGGAGCCCTCCTCCCTTGAGGTTGTCATGTCCGACGCCGAGAACAGGGATTGCGTCGCTATTCTC
GTCGCGGTGAAAACCGAGGCAAAAAGAGCCATTCGAGTGAACGTTACGCTTCCCGAAGGTGTCCTGAAGCAGATAGATGC
CTTCGCCGAAGCCCACGGCCTTACGCGGTCTGGATTTCTTGCTCGTGCTGCAACGCACGAGATCGAACGGGCAAATGACG
GCCACGACGCCTATGCGGAATCCCGCTTGTCGGCTTTGGGCACTTCCAGCAAAAATGTGTAA

Structures

Toxin

• AlphaFold DB: H0G1A3

Antitoxin

• AlphaFold DB: Q92NX0