Detailed information of TA system TA095044

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 890211..890851
• Replicon: chromosome
• Accession: NZ_CP026525
• Organism: Sinorhizobium meliloti strain AK21

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: C3L21_RS04170
• Protein ID: WP_127521467.1
• Coordinates: 890211..890597 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: H0G6N0
• Locus tag: C3L21_RS04175
• Protein ID: WP_003533689.1
• Coordinates: 890597..890851 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C3L21_RS04145	885704..886183	+	480	WP_003537307.1	GNAT family N-acetyltransferase	-
C3L21_RS04150	886225..886674	-	450	WP_003537305.1	nucleoside deaminase	-
C3L21_RS04155	886749..888443	+	1695	WP_015007224.1	pseudouridine synthase	-
C3L21_RS04160	888450..889010	+	561	WP_010968831.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
C3L21_RS04165	889083..889982	+	900	WP_010968832.1	patatin-like phospholipase family protein	-
C3L21_RS04170	890211..890597	-	387	WP_127521467.1	type II toxin-antitoxin system VapC family toxin	Toxin
C3L21_RS04175	890597..890851	-	255	WP_003533689.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
C3L21_RS04180	890990..892822	-	1833	WP_003533687.1	monovalent cation:proton antiporter-2 (CPA2) family protein	-
C3L21_RS04185	892974..894320	+	1347	WP_027989724.1	TldD/PmbA family protein	-
C3L21_RS04190	894429..895247	+	819	WP_027989723.1	3'(2'),5'-bisphosphate nucleotidase CysQ	-
C3L21_RS04195	895308..895544	+	237	WP_003533684.1	DUF4170 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-83)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 13874.79 Da
• Isoelectric Point: 4.6899

>T95044 WP_127521467.1 NZ_CP026525:c890597-890211 [Sinorhizobium meliloti]
MVIDTSAIAAIAFNEQEAGSFREKIADDPVRLISAATALEAAMVIVTRLGEAAGAELDLWLYKANVEIVAVTAEHMDQAR
RAWRRFGKGRHPAGLNFGDCFSYALAFLTNEPLLFKGSDFSQTDIPAA

Nucleotide

• Length: 387 bp

>T95044 NZ_CP026525:c890597-890211 [Sinorhizobium meliloti]
ATGGTCATCGACACATCCGCCATTGCCGCGATTGCCTTCAATGAACAAGAGGCCGGAAGTTTCCGCGAAAAAATCGCGGA
CGACCCGGTTCGGCTCATCTCCGCGGCAACCGCTCTGGAAGCGGCCATGGTAATCGTAACCCGGTTAGGCGAAGCTGCCG
GAGCGGAACTTGATCTTTGGCTTTACAAGGCAAACGTGGAGATTGTTGCGGTAACCGCCGAGCATATGGACCAGGCCCGC
CGTGCCTGGCGCCGTTTCGGCAAAGGCCGTCATCCGGCCGGTTTGAATTTCGGTGATTGTTTTTCCTATGCCCTGGCCTT
TCTGACAAATGAACCGCTTCTCTTCAAGGGAAGCGATTTCTCGCAAACCGATATCCCGGCGGCATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9472.63 Da
• Isoelectric Point: 4.8660

>AT95044 WP_003533689.1 NZ_CP026525:c890851-890597 [Sinorhizobium meliloti]
MALSIKDTETEQLARTLARRTGESITLATKRALEERLRRTDTAARRAALLEDLEAIQRRWNAMPVLDSRSSDDIIGYDED
GLPS

Nucleotide

• Length: 255 bp

>AT95044 NZ_CP026525:c890851-890597 [Sinorhizobium meliloti]
ATGGCGCTGAGCATCAAGGACACTGAAACCGAGCAGCTTGCCCGCACACTTGCCCGGCGGACAGGGGAATCCATCACGCT
TGCCACCAAGCGTGCCCTCGAAGAACGATTGCGCCGAACCGACACCGCTGCCCGGCGCGCGGCTCTTCTGGAGGATCTGG
AAGCCATTCAACGCCGCTGGAATGCCATGCCCGTCCTCGACAGTCGCAGCTCCGATGACATTATCGGTTATGACGAGGAT
GGACTCCCCTCATAA

Structures

Antitoxin

• AlphaFold DB: H0G6N0