Detailed information of TA system TA095042

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pemK-mazE/MazF(toxin)
• Location: 1142523..1143129
• Replicon: chromosome
• Accession: NZ_CP026520
• Organism: Paenibacillus chitinolyticus strain KCCM 41400

Toxin (Protein)

• Gene name: pemK
• Uniprot ID: F5LMI0
• Locus tag: PC41400_RS05085
• Protein ID: WP_009675190.1
• Coordinates: 1142779..1143129 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: PC41400_RS05080
• Protein ID: WP_170318689.1
• Coordinates: 1142523..1142774 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PC41400_RS05070	1139474..1140895	+	1422	WP_129112454.1	outer membrane lipoprotein-sorting protein	-
PC41400_RS05075	1141078..1142277	+	1200	WP_042235933.1	alanine racemase	-
PC41400_RS05080	1142523..1142774	+	252	WP_170318689.1	ribbon-helix-helix protein, CopG family	Antitoxin
PC41400_RS05085	1142779..1143129	+	351	WP_009675190.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
PC41400_RS05090	1143405..1145543	+	2139	WP_176564514.1	RNA-binding transcriptional accessory protein	-
PC41400_RS05095	1145738..1146997	+	1260	WP_042235927.1	beta-N-acetylhexosaminidase	-
PC41400_RS05100	1147045..1147191	-	147	WP_085981306.1	cortex morphogenetic protein CmpA	-
PC41400_RS05105	1147288..1147653	-	366	WP_042235925.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-113)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-35)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12894.79 Da
• Isoelectric Point: 4.8837

>T95042 WP_009675190.1 NZ_CP026520:1142779-1143129 [Paenibacillus chitinolyticus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAETHGFDRDSVILLEQI
RTIDKQRLTDKITHLDEESMRKVDEALQVSVGLIDF

Nucleotide

• Length: 351 bp

>T95042 NZ_CP026520:1142779-1143129 [Paenibacillus chitinolyticus]
TTGATTGTAAAACGTGGCGATGTGTACTTCGCAGATCTTTCACCGGTTGTCGGTTCCGAACAGGGCGGCGTCCGTCCGGT
GCTGATTATCCAGAACGACATCGGCAATCGCTTCAGCCCGACGGTCATCGTCGCCGCAATTACGGCGCAGATTCAGAAAG
CGAAGCTACCGACGCACGTGGAAATCGATGCGGAAACGCACGGTTTCGACCGGGACTCCGTCATTTTGCTGGAACAGATC
CGTACGATCGACAAACAGCGGCTGACCGACAAAATTACGCATCTGGATGAAGAATCAATGCGCAAGGTGGACGAAGCGCT
GCAGGTCAGCGTGGGACTGATTGATTTCTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9577.00 Da
• Isoelectric Point: 4.6683

>AT95042 WP_170318689.1 NZ_CP026520:1142523-1142774 [Paenibacillus chitinolyticus]
MISLPDNLLQEVDGIVEKENSNRSEFIRQAMKLYLLERKKRSLRESMQKGYMEMAKINLTIADEAFQAEEEADNTLVRLV
SGV

Nucleotide

• Length: 252 bp

>AT95042 NZ_CP026520:1142523-1142774 [Paenibacillus chitinolyticus]
ATGATCAGTTTGCCAGACAACCTATTACAGGAGGTCGACGGCATTGTGGAGAAGGAGAACTCCAACCGAAGCGAGTTTAT
TCGCCAGGCCATGAAGCTGTATTTGCTTGAACGCAAAAAACGCAGCCTTCGCGAATCCATGCAGAAAGGTTACATGGAGA
TGGCTAAAATCAACCTAACGATAGCGGACGAAGCTTTTCAAGCGGAGGAAGAGGCGGACAATACGCTGGTACGCTTAGTA
AGCGGGGTGTAA

Structures

Toxin

• AlphaFold DB: A0A7X3FKV3