Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 277827..278443 Replicon plasmid unnamed2
Accession NZ_CP026518
Organism Deinococcus sp. NW-56

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag C3K08_RS16890 Protein ID WP_104992605.1
Coordinates 278144..278443 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag C3K08_RS16885 Protein ID WP_104992604.1
Coordinates 277827..278147 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3K08_RS16855 273319..274095 + 777 WP_104992599.1 SDR family oxidoreductase -
C3K08_RS16860 274105..274563 + 459 WP_104992600.1 MaoC family dehydratase -
C3K08_RS16865 274560..275006 + 447 WP_104992601.1 PaaI family thioesterase -
C3K08_RS16870 275003..276091 + 1089 WP_104992602.1 SMP-30/gluconolactonase/LRE family protein -
C3K08_RS16875 276133..276423 + 291 WP_104992685.1 hypothetical protein -
C3K08_RS16880 276420..277658 + 1239 WP_104992603.1 acyl-CoA dehydrogenase family protein -
C3K08_RS16885 277827..278147 - 321 WP_104992604.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C3K08_RS16890 278144..278443 - 300 WP_104992605.1 type II toxin-antitoxin system HicA family toxin Toxin
C3K08_RS16895 278442..279260 + 819 WP_104992606.1 SDR family oxidoreductase -
C3K08_RS16900 279257..280336 + 1080 WP_104992607.1 phosphotransferase family protein -
C3K08_RS16905 280403..280903 + 501 WP_104992608.1 DUF421 domain-containing protein -
C3K08_RS16910 280923..281627 + 705 WP_104992609.1 histidine phosphatase family protein -
C3K08_RS16915 281637..282569 + 933 WP_104992610.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..373067 373067


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(38-96)

Antitoxin

Uncharacterised protein family HicB

(52-102)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11059.50 Da        Isoelectric Point: 11.5772

>T95041 WP_104992605.1 NZ_CP026518:c278443-278144 [Deinococcus sp. NW-56]
MGSPFGGTGFRYYKTVNTRQRRTLGRVFEQPTRSDVAWTDVEALFRALGADITEGNGSRVRVALNGVRAVFHRPHPEKET
DRGALVSVRRFLENAGVKP

Download         Length: 300 bp

>T95041 NZ_CP026518:c278443-278144 [Deinococcus sp. NW-56]
ATGGGTTCTCCTTTTGGTGGTACTGGATTCAGGTACTATAAGACCGTGAATACCCGTCAGCGCCGCACTCTGGGGCGGGT
CTTCGAACAGCCCACCCGGAGTGACGTGGCCTGGACAGACGTCGAAGCGTTGTTCCGGGCGCTGGGGGCCGACATCACCG
AGGGAAACGGGAGCCGGGTGCGGGTGGCCCTGAACGGCGTTCGCGCGGTCTTCCACCGTCCCCACCCGGAAAAGGAAACG
GACCGGGGGGCGCTGGTGAGCGTGCGGCGCTTTCTGGAGAATGCAGGGGTGAAGCCATGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12072.50 Da        Isoelectric Point: 4.7650

>AT95041 WP_104992604.1 NZ_CP026518:c278147-277827 [Deinococcus sp. NW-56]
MMEYKGYIGTATFDDAADLFHGEVINLRDVITFQGRSVDELRQAFRESVDDYLAFCAERGEEPERPFSGRFNLRISPELH
ARAVARARSEGLSLNAFVERALERVT

Download         Length: 321 bp

>AT95041 NZ_CP026518:c278147-277827 [Deinococcus sp. NW-56]
ATGATGGAATACAAGGGGTATATCGGCACCGCCACCTTCGACGACGCGGCCGATCTGTTTCACGGCGAGGTCATCAATCT
GCGCGACGTGATCACCTTTCAGGGGCGCAGCGTGGACGAGTTGCGGCAGGCTTTTCGCGAGAGCGTGGACGATTACCTGG
CCTTTTGCGCCGAGCGGGGTGAGGAACCGGAACGGCCCTTCAGTGGCCGCTTCAACCTCCGTATCAGCCCCGAACTGCAT
GCCCGCGCCGTCGCCCGCGCCCGCAGCGAGGGCCTGAGCCTCAACGCCTTTGTGGAACGGGCACTGGAGCGGGTGACCTG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References