Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3918695..3919314 Replicon chromosome
Accession NZ_CP026495
Organism Klebsiella pneumoniae strain 616

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag C2861_RS19425 Protein ID WP_002892050.1
Coordinates 3919096..3919314 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag C2861_RS19420 Protein ID WP_002892066.1
Coordinates 3918695..3919069 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2861_RS19410 3913847..3915040 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
C2861_RS19415 3915063..3918209 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
C2861_RS19420 3918695..3919069 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
C2861_RS19425 3919096..3919314 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
C2861_RS19430 3919473..3920039 + 567 WP_002892030.1 maltose O-acetyltransferase -
C2861_RS27320 3920011..3920151 - 141 WP_004147370.1 hypothetical protein -
C2861_RS19435 3920172..3920642 + 471 WP_002892026.1 YlaC family protein -
C2861_RS19440 3920617..3922068 - 1452 WP_032435563.1 PLP-dependent aminotransferase family protein -
C2861_RS19445 3922169..3922867 + 699 WP_032435564.1 GNAT family N-acetyltransferase -
C2861_RS19450 3922864..3923004 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
C2861_RS19455 3923004..3923267 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T95027 WP_002892050.1 NZ_CP026495:3919096-3919314 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T95027 NZ_CP026495:3919096-3919314 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT95027 WP_002892066.1 NZ_CP026495:3918695-3919069 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT95027 NZ_CP026495:3918695-3919069 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References