Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2887375..2888219 Replicon chromosome
Accession NZ_CP026473
Organism Escherichia coli strain KBN10P04869

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag YKEC1_RS14930 Protein ID WP_000854686.1
Coordinates 2887375..2887758 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0J1S3
Locus tag YKEC1_RS14935 Protein ID WP_001285602.1
Coordinates 2887839..2888219 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YKEC1_RS14890 2882378..2882869 - 492 WP_001297187.1 DUF1097 domain-containing protein -
YKEC1_RS14895 2882971..2883525 - 555 WP_001001902.1 molecular chaperone YcdY -
YKEC1_RS14900 2883549..2884286 - 738 WP_000283664.1 zinc-binding phosphatase -
YKEC1_RS14905 2884341..2885279 - 939 WP_000351311.1 glyoxylate/hydroxypyruvate reductase GhrA -
YKEC1_RS14915 2885750..2886591 - 842 Protein_2747 DUF4942 domain-containing protein -
YKEC1_RS14920 2886676..2886873 - 198 WP_000839253.1 DUF957 domain-containing protein -
YKEC1_RS14925 2886890..2887378 - 489 WP_032180032.1 hypothetical protein -
YKEC1_RS14930 2887375..2887758 - 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
YKEC1_RS14935 2887839..2888219 - 381 WP_001285602.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
YKEC1_RS14940 2888230..2888913 - 684 WP_000086768.1 hypothetical protein -
YKEC1_RS14945 2888932..2889153 - 222 WP_000692298.1 DUF987 domain-containing protein -
YKEC1_RS14950 2889216..2889692 - 477 WP_001186726.1 RadC family protein -
YKEC1_RS14955 2889708..2890193 - 486 WP_000214307.1 antirestriction protein -
YKEC1_RS14960 2890285..2891106 - 822 WP_001761104.1 DUF945 domain-containing protein -
YKEC1_RS26505 2891207..2891415 - 209 Protein_2757 DUF905 domain-containing protein -
YKEC1_RS14970 2891516..2891971 - 456 WP_000581506.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T94960 WP_000854686.1 NZ_CP026473:c2887758-2887375 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T94960 NZ_CP026473:c2887758-2887375 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13938.69 Da        Isoelectric Point: 5.0823

>AT94960 WP_001285602.1 NZ_CP026473:c2888219-2887839 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT94960 NZ_CP026473:c2888219-2887839 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References