Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 19160..19737 Replicon plasmid pACI-b25a
Accession NZ_CP026423
Organism Acinetobacter sp. ACNIH1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag C3F22_RS16310 Protein ID WP_004897309.1
Coordinates 19160..19408 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag C3F22_RS16315 Protein ID WP_004897307.1
Coordinates 19405..19737 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3F22_RS16275 14254..15564 + 1311 WP_004758940.1 replication initiation protein -
C3F22_RS16280 15688..16686 - 999 WP_004758941.1 ParB/RepB/Spo0J family partition protein -
C3F22_RS16285 16686..17303 - 618 WP_004758942.1 AAA family ATPase -
C3F22_RS16290 17490..17645 - 156 Protein_13 IS5/IS1182 family transposase -
C3F22_RS16295 17760..18005 - 246 WP_004282220.1 hypothetical protein -
C3F22_RS16300 18160..18384 + 225 WP_004758944.1 hypothetical protein -
C3F22_RS16305 18723..19004 - 282 WP_004897311.1 hypothetical protein -
C3F22_RS16310 19160..19408 + 249 WP_004897309.1 type II toxin-antitoxin system HicA family toxin Toxin
C3F22_RS16315 19405..19737 + 333 WP_004897307.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C3F22_RS16320 19801..20953 - 1153 Protein_19 IS4 family transposase -
C3F22_RS16325 21132..22148 - 1017 WP_104427049.1 spore coat U domain-containing protein -
C3F22_RS16330 22145..24676 - 2532 WP_104427050.1 fimbrial biogenesis outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - csuD / csuA/B 1..40249 40249


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-78)

Antitoxin

Uncharacterised protein family HicB

(54-101)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9501.14 Da        Isoelectric Point: 10.3185

>T94849 WP_004897309.1 NZ_CP026423:19160-19408 [Acinetobacter sp. ACNIH1]
MGKTEKLLEKLGNSKNTFPYKDLVVLLSQLGYEKFEMAGSRVRFFNEKTEHMILLHRPHPENEIKGGALKAVKQALKQER
FL

Download         Length: 249 bp

>T94849 NZ_CP026423:19160-19408 [Acinetobacter sp. ACNIH1]
ATGGGTAAAACGGAAAAGTTATTGGAAAAACTTGGAAATTCAAAAAATACATTTCCATATAAAGATTTAGTCGTTTTACT
AAGCCAACTCGGTTATGAAAAGTTTGAAATGGCAGGCTCTCGTGTTCGTTTTTTTAATGAAAAAACTGAACATATGATTT
TACTGCATAGACCACACCCTGAGAATGAAATCAAAGGCGGTGCATTGAAAGCTGTAAAACAGGCACTTAAGCAGGAGAGA
TTTTTATGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12408.18 Da        Isoelectric Point: 4.8838

>AT94849 WP_004897307.1 NZ_CP026423:19405-19737 [Acinetobacter sp. ACNIH1]
MSYLKYKGYLGTIEPDLETGELFGKVAFIRDLITYEAETLKALEQAFQESVDGYLESCIELNKKPDQPFKGTFNVRISPD
LHRKAVLASSNSLNNFVSDAIQEKLMRLGV

Download         Length: 333 bp

>AT94849 NZ_CP026423:19405-19737 [Acinetobacter sp. ACNIH1]
ATGAGCTATCTAAAATATAAAGGTTATCTTGGAACAATTGAGCCTGATTTAGAAACAGGTGAGTTGTTTGGAAAAGTTGC
TTTTATACGTGATTTAATCACTTATGAAGCCGAAACATTAAAAGCATTAGAACAAGCTTTTCAAGAATCTGTAGATGGCT
ATTTAGAATCTTGTATCGAACTAAATAAAAAACCAGATCAGCCTTTTAAAGGTACGTTTAATGTACGGATTAGCCCTGAT
CTACACCGTAAAGCTGTTTTAGCATCAAGTAATTCCTTGAATAACTTTGTAAGCGATGCAATTCAAGAAAAGCTAATGCG
TCTAGGTGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References