Detailed information of TA system TA094838

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 4662374..4663067
• Replicon: chromosome
• Accession: NZ_CP026406
• Organism: Aeromonas sp. ASNIH2

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: C3F36_RS22160
• Protein ID: WP_000182276.1
• Coordinates: 4662711..4663067 (-)
• Length: 119 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: N2IIN5
• Locus tag: C3F36_RS22155
• Protein ID: WP_001172026.1
• Coordinates: 4662374..4662709 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C3F36_RS22110	4657759..4658367	-	609	WP_010674753.1	paraquat-inducible protein A	-
C3F36_RS22115	4658345..4658989	-	645	WP_010674754.1	paraquat-inducible protein A	-
C3F36_RS22120	4659210..4659311	+	102	Protein_4240	YebG family protein	-
C3F36_RS22125	4659351..4659746	-	396	Protein_4241	recombinase family protein	-
C3F36_RS22130	4659913..4660827	-	915	WP_001736514.1	HD domain-containing protein	-
C3F36_RS22135	4660874..4661179	-	306	WP_072071574.1	DUF3391 domain-containing protein	-
C3F36_RS22140	4661297..4661677	-	381	WP_001054412.1	hypothetical protein	-
C3F36_RS22145	4661674..4662000	-	327	WP_000091614.1	hypothetical protein	-
C3F36_RS22150	4662024..4662359	-	336	WP_000741275.1	hypothetical protein	-
C3F36_RS22155	4662374..4662709	-	336	WP_001172026.1	helix-turn-helix domain-containing protein	Antitoxin
C3F36_RS22160	4662711..4663067	-	357	WP_000182276.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C3F36_RS22165	4663259..4663861	+	603	WP_010465829.1	recombinase family protein	-
C3F36_RS22170	4663845..4666874	+	3030	WP_032432545.1	Tn3 family transposase	-
C3F36_RS22175	4667111..4667956	+	846	WP_003464995.1	AraC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	aph(3'')-Ib / aph(6)-Id / tet(E)	-	4659210..4728023	68813

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (40-93)

Sequences

Toxin

Protein

• Length: 119 a.a.
• Molecular weight: 12912.93 Da
• Isoelectric Point: 8.9018

>T94838 WP_000182276.1 NZ_CP026406:c4663067-4662711 [Aeromonas sp. ASNIH2]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKELKGFGGAGVLKVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQEL

Nucleotide

• Length: 357 bp

>T94838 NZ_CP026406:c4663067-4662711 [Aeromonas sp. ASNIH2]
ATGACAAACAAAGAAAAACCGCTCGAATGGATCGCGAGCAGCCACAAGGATTTGATGGCGTTGCCGTCCGACGTGCGTCG
CCGTTTCGGTTACGCGCTCTCGTTGGCGCAGATAGGCGATCAGGATGACGCAGCAAAGGAGCTCAAGGGGTTCGGTGGTG
CCGGCGTGCTGAAGGTCGTCGAAGACGATGCCGGCGGCACCTATCGAGCGGTATACACGGTCAAGTTTGCGGAAGCGGTG
TTCGTCCTGCACTGCTTCCAGAAGAAGAGCAAGAGCGGAATCGCCACGCCAAAGGCCGACATGGACATCATCCGCGCTCG
GCTGAAGGTGGCCGAGGTATTGGCACAGGAGCTATGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12201.39 Da
• Isoelectric Point: 10.6058

>AT94838 WP_001172026.1 NZ_CP026406:c4662709-4662374 [Aeromonas sp. ASNIH2]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Nucleotide

• Length: 336 bp

>AT94838 NZ_CP026406:c4662709-4662374 [Aeromonas sp. ASNIH2]
ATGCAAAAACGAATCATTGAAGGCGTCGAGGTTCAGCGCAGCTCGGGCAACGTCTTTGCCGACCTTGGACTGCCTGACGC
TGAAAAGCTCAAGATCAAGACCGGCCTGGTGGTCGAGATCAGGAGGGCCATGCGCGCCCTTGGGCTGACTCAACAAGCGG
CGGCCAAACGCATGGGCATCCCGCAACCGAAGGTGTCGGGCATGATGCGCGGCGACTTCACCAATCTATCCGAACGCAAG
CTGATGGATTGTCTGAATCGCCTCGGCTACGACATCGAAATCAAGGTACGGCCAGCAGCCGAGCCGATCGGGCATCTAAC
GCTCGCAACCGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A024EKI7