Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 37522..38093 Replicon plasmid pECO-c85f
Accession NZ_CP026405
Organism Escherichia coli strain ECONIH4

Toxin (Protein)


Gene name parE Uniprot ID A0A2I8S8S5
Locus tag C3F40_RS30190 Protein ID WP_011918375.1
Coordinates 37522..37833 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1Z3MW28
Locus tag C3F40_RS30195 Protein ID WP_011787805.1
Coordinates 37833..38093 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3F40_RS30180 32860..34380 - 1521 WP_103216134.1 ATP-dependent helicase -
C3F40_RS30185 34418..37498 - 3081 WP_011787830.1 Tn3 family transposase -
C3F40_RS30190 37522..37833 - 312 WP_011918375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C3F40_RS30195 37833..38093 - 261 WP_011787805.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C3F40_RS31400 38309..38476 - 168 Protein_49 IS6 family transposase -
C3F40_RS30210 38530..39234 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
C3F40_RS30215 39299..39661 - 363 Protein_51 class 1 integron integrase IntI1 -
C3F40_RS30220 39763..40614 + 852 WP_000946487.1 sulfonamide-resistant dihydropteroate synthase Sul1 -
C3F40_RS30230 40742..41242 + 501 WP_000376623.1 GNAT family N-acetyltransferase -
C3F40_RS30235 41367..42977 - 1611 WP_011787758.1 IS1634-like element ISSpu7 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul1 / mph(E) / msr(E) / qnrA1 / qacE / aadA2 - 1..186884 186884


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-61)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11862.70 Da        Isoelectric Point: 8.5341

>T94836 WP_011918375.1 NZ_CP026405:c37833-37522 [Escherichia coli]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRMNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII

Download         Length: 312 bp

>T94836 NZ_CP026405:c37833-37522 [Escherichia coli]
ATGCCGGTAACTTATCATTTAACGCCCGATGCACAATCTGATCTGATAGGTATTCACCGCTTTACGTTAGCCCAATGGGG
AACGACTCAGTCGAAGACCTATTTATCAGGACTTAGACAAACGATTCAACTGCTGGCTGAAACACCCACCCTTGGGAAAA
ATAGACCCGAGGTACGCATGAATGTGTTTAGCTTCCCTTATTCAAGTCATGTCATCTATTACATCCAACATGAGCATCAA
TTCGTTGTATTTGGGATCTTACATAAAAGTATGGTTCCACTTGCACATCTCGCGGAGCGGGAAATTATTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9312.71 Da        Isoelectric Point: 6.4546

>AT94836 WP_011787805.1 NZ_CP026405:c38093-37833 [Escherichia coli]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAITDIKMGNLVDGNTFFDEL
AAGQYD

Download         Length: 261 bp

>AT94836 NZ_CP026405:c38093-37833 [Escherichia coli]
ATGAACACTCTTTCAGCCAATGAAGCAAAAATTCACTTTGGAGATTTGTTGCTCAAAGCTCAACAAGCTCCAATCCAAAT
TAATAAAAATGGCAAGCCTGTGGCCGTTGTTATTTCAGCTGATGCATACCAAAGTATCGAGACACTAAAATTACATTTGC
TTCAATCCAAAGCGGTGAAAGCCATAACTGACATCAAAATGGGCAATTTGGTTGATGGTAATACCTTTTTTGATGAGCTG
GCCGCAGGGCAGTATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S8S5

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3MW28

References